CATH Superfamily 1.10.1630.10
Nuclear receptor coactivator, CREB-bp-like, interlocking domain
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Nuclear receptor coactivator, CREB-bp-like, interlocking domain
".
FunFam 2: Uncharacterized protein, isoform C
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 9 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
1 | Q95TP4 (/IDA) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
1 | Q95TP4 (/IGI) |
|
Histone acetyltransferase activity GO:0004402
Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.
|
1 | Q95TP4 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q95TP4 (/IPI) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
1 | Q95TP4 (/IPI) |
|
CAMP response element binding protein binding GO:0008140
Interacting selectively and non-covalently with a cAMP response element binding protein (a CREB protein).
|
1 | Q95TP4 (/TAS) |
|
Histone acetyltransferase activity (H3-K18 specific) GO:0043993
Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 18) = CoA + histone H3 N6-acetyl-L-lysine (position 18).
|
1 | Q95TP4 (/IDA) |
|
Histone acetyltransferase activity (H3-K27 specific) GO:0044017
Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 27) = CoA + histone H3 N6-acetyl-L-lysine (position 27).
|
1 | Q95TP4 (/IDA) |
|
Histone methyltransferase binding GO:1990226
Interacting selectively and non-covalently with a histone methyltransferase enzyme.
|
1 | Q95TP4 (/IPI) |
There are 25 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA replication checkpoint GO:0000076
A cell cycle checkpoint that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.
|
1 | Q95TP4 (/IMP) |
|
Compound eye morphogenesis GO:0001745
The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
|
1 | Q95TP4 (/IMP) |
|
Regulation of mitotic nuclear division GO:0007088
Any process that modulates the frequency, rate or extent of mitosis.
|
1 | Q95TP4 (/IGI) |
|
Regulation of mitotic nuclear division GO:0007088
Any process that modulates the frequency, rate or extent of mitosis.
|
1 | Q95TP4 (/IMP) |
|
Smoothened signaling pathway GO:0007224
A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
|
1 | Q95TP4 (/NAS) |
|
Neurotransmitter secretion GO:0007269
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
|
1 | Q95TP4 (/IMP) |
|
Synapse assembly GO:0007416
The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional).
|
1 | Q95TP4 (/IMP) |
|
R3/R4 cell fate commitment GO:0007464
The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres.
|
1 | Q95TP4 (/IMP) |
|
Glial cell migration GO:0008347
The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.
|
1 | Q95TP4 (/IMP) |
|
Wnt signaling pathway GO:0016055
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.
|
1 | Q95TP4 (/NAS) |
|
Histone acetylation GO:0016573
The modification of a histone by the addition of an acetyl group.
|
1 | Q95TP4 (/IDA) |
|
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
|
1 | Q95TP4 (/TAS) |
|
Ovarian follicle cell development GO:0030707
The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster.
|
1 | Q95TP4 (/IMP) |
|
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
|
1 | Q95TP4 (/IMP) |
|
Thermosensory behavior GO:0040040
Behavior that is dependent upon the sensation of temperature.
|
1 | Q95TP4 (/IMP) |
|
Histone H3-K18 acetylation GO:0043971
The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 18 of the histone.
|
1 | Q95TP4 (/IDA) |
|
Histone H3-K27 acetylation GO:0043974
The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 27 of the histone.
|
1 | Q95TP4 (/IDA) |
|
Histone H4-K8 acetylation GO:0043982
The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone.
|
1 | Q95TP4 (/IMP) |
|
Histone H4-K12 acetylation GO:0043983
The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 12 of the histone.
|
1 | Q95TP4 (/IMP) |
|
R7 cell differentiation GO:0045466
The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor.
|
1 | Q95TP4 (/IMP) |
|
Locomotor rhythm GO:0045475
The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.
|
1 | Q95TP4 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q95TP4 (/IGI) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q95TP4 (/IMP) |
|
Compound eye development GO:0048749
The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.
|
1 | Q95TP4 (/IMP) |
|
Histone H3-K4 methylation GO:0051568
The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.
|
1 | Q95TP4 (/IDA) |
There are 6 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Histone acetyltransferase complex GO:0000123
A protein complex that possesses histone acetyltransferase activity.
|
1 | Q95TP4 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q95TP4 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q95TP4 (/HDA) |
|
Polytene chromosome GO:0005700
A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.
|
1 | Q95TP4 (/IDA) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
1 | Q95TP4 (/IPI) |
|
Histone methyltransferase complex GO:0035097
A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins.
|
1 | Q95TP4 (/IDA) |