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CATH Superfamily 1.10.1530.10

Malate/L-lactate/L-sulpholactate dehydrogenase, four-helix barrel

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Ureidoglycolate dehydrogenase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
N-methylalanine dehydrogenase. [EC: 1.4.1.17]
N-methyl-L-alanine + H(2)O + NADP(+) = pyruvate + methylamine + NADPH.
    		 9 A0A2R3FBZ7 A0A2R3FBZ7 A0A2R3FBZ7 A0A3M3YUC9 A0A3M3YUC9 A0A3M3YUC9 Q4U331 Q4U331 Q4U331
    1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH). [EC: 1.5.1.21]
    (1) L-pipecolate + NADP(+) = 1-piperideine-2-carboxylate + NADPH. (2) L-proline + NADP(+) = 1-pyrroline-2-carboxylate + NADPH.
    • The enzyme is involved in the catabolism of D-lysine and D-proline in bacteria that belong to the Pseudomonas genus.
    • In contrast to EC 1.5.1.1, which shows similar activity with NADPH and NADH, this enzyme is specific for NADPH.
    • Formerly EC 1.5.1.14.
    		 9 A0A2R3FBZ7 A0A2R3FBZ7 A0A2R3FBZ7 A0A3M3YUC9 A0A3M3YUC9 A0A3M3YUC9 Q4U331 Q4U331 Q4U331