The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Ribonuclease III domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 1: Ribonuclease 3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ribonuclease III activity GO:0004525
Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
156 P0A7Y0 (/IDA) P0A7Y0 (/IDA) P0A7Y0 (/IDA) P0A7Y0 (/IDA) P0A7Y0 (/IDA) P0A7Y0 (/IDA) P0A7Y0 (/IDA) P0A7Y0 (/IDA) P0A7Y0 (/IDA) P0A7Y0 (/IDA)
(146 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
155 P0A7Y0 (/IPI) P0A7Y0 (/IPI) P0A7Y0 (/IPI) P0A7Y0 (/IPI) P0A7Y0 (/IPI) P0A7Y0 (/IPI) P0A7Y0 (/IPI) P0A7Y0 (/IPI) P0A7Y0 (/IPI) P0A7Y0 (/IPI)
(145 more)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
147 P0A7Y0 (/IDA) P0A7Y0 (/IDA) P0A7Y0 (/IDA) P0A7Y0 (/IDA) P0A7Y0 (/IDA) P0A7Y0 (/IDA) P0A7Y0 (/IDA) P0A7Y0 (/IDA) P0A7Y0 (/IDA) P0A7Y0 (/IDA)
(137 more)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
147 P0A7Y0 (/IPI) P0A7Y0 (/IPI) P0A7Y0 (/IPI) P0A7Y0 (/IPI) P0A7Y0 (/IPI) P0A7Y0 (/IPI) P0A7Y0 (/IPI) P0A7Y0 (/IPI) P0A7Y0 (/IPI) P0A7Y0 (/IPI)
(137 more)
Ribonuclease III activity GO:0004525
Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
37 Q3Z7Q8 (/ISS) Q5HSF8 (/ISS) Q71YL2 (/ISS) Q71YL2 (/ISS) Q71YL2 (/ISS) Q71YL2 (/ISS) Q71YL2 (/ISS) Q71YL2 (/ISS) Q81WI8 (/ISS) Q81WI8 (/ISS)
(27 more)
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
1 P22192 (/IDA)
RNA-directed 5'-3' RNA polymerase activity GO:0003968
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.
1 A0A1D8PM62 (/IDA)
RNA-directed 5'-3' RNA polymerase activity GO:0003968
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.
1 A0A1D8PM62 (/IMP)
Ribonuclease III activity GO:0004525
Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
1 A0A1D8PM62 (/TAS)
Double-stranded RNA-specific ribonuclease activity GO:0032296
Catalysis of the hydrolysis of phosphodiester bonds in double-stranded RNA molecules.
1 P22192 (/IDA)
RNA stem-loop binding GO:0035613
Interacting selectively and non-covalently with a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop.
1 P22192 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 O67082 (/IPI)

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RRNA processing GO:0006364
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
157 A0A1D8PM62 (/IMP) P0A7Y0 (/IMP) P0A7Y0 (/IMP) P0A7Y0 (/IMP) P0A7Y0 (/IMP) P0A7Y0 (/IMP) P0A7Y0 (/IMP) P0A7Y0 (/IMP) P0A7Y0 (/IMP) P0A7Y0 (/IMP)
(147 more)
RNA processing GO:0006396
Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
147 P0A7Y0 (/IMP) P0A7Y0 (/IMP) P0A7Y0 (/IMP) P0A7Y0 (/IMP) P0A7Y0 (/IMP) P0A7Y0 (/IMP) P0A7Y0 (/IMP) P0A7Y0 (/IMP) P0A7Y0 (/IMP) P0A7Y0 (/IMP)
(137 more)
MRNA processing GO:0006397
Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
147 P0A7Y0 (/IMP) P0A7Y0 (/IMP) P0A7Y0 (/IMP) P0A7Y0 (/IMP) P0A7Y0 (/IMP) P0A7Y0 (/IMP) P0A7Y0 (/IMP) P0A7Y0 (/IMP) P0A7Y0 (/IMP) P0A7Y0 (/IMP)
(137 more)
RNA processing GO:0006396
Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
37 Q3Z7Q8 (/ISS) Q5HSF8 (/ISS) Q71YL2 (/ISS) Q71YL2 (/ISS) Q71YL2 (/ISS) Q71YL2 (/ISS) Q71YL2 (/ISS) Q71YL2 (/ISS) Q81WI8 (/ISS) Q81WI8 (/ISS)
(27 more)
U4 snRNA 3'-end processing GO:0034475
Any process involved in forming the mature 3' end of a U4 snRNA molecule.
9 P22192 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP)
Nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay GO:0000294
A minor degradation pathway nuclear-transcribed mRNAs that begins with an endonucleolytic cleavage to generate unprotected ends.
8 Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA)
Nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay GO:0000294
A minor degradation pathway nuclear-transcribed mRNAs that begins with an endonucleolytic cleavage to generate unprotected ends.
8 Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP)
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
8 Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP)
RRNA transcription GO:0009303
The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template.
8 Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP)
Termination of RNA polymerase II transcription, exosome-dependent GO:0030847
The process in which transcription of nonpolyadenylated RNA polymerase II transcripts is terminated; coupled to the maturation of the RNA 3'-end.
8 Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA)
Termination of RNA polymerase II transcription, exosome-dependent GO:0030847
The process in which transcription of nonpolyadenylated RNA polymerase II transcripts is terminated; coupled to the maturation of the RNA 3'-end.
8 Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP)
U1 snRNA 3'-end processing GO:0034473
Any process involved in forming the mature 3' end of a U1 snRNA molecule.
8 Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP)
U5 snRNA 3'-end processing GO:0034476
Any process involved in forming the mature 3' end of a U5 snRNA molecule.
8 Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA)
U5 snRNA 3'-end processing GO:0034476
Any process involved in forming the mature 3' end of a U5 snRNA molecule.
8 Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP)
Box C/D snoRNA processing GO:0034963
Any process involved in the conversion of a primary box C/D type small nucleolar RNA (snoRNA) transcript into a mature box C/D snoRNA.
8 Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP)
Box H/ACA snoRNA processing GO:0034964
Any process involved in the conversion of a primary box H/ACA type small nucleolar RNA (snoRNA) transcript into a mature box H/ACA snoRNA.
8 Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP)
Regulation of fungal-type cell wall organization GO:0060237
Any process that modulates the rate, frequency or extent of the formation, arrangement of constituent parts, or disassembly of the fungal-type cell wall.
8 Q02555 (/IGI) Q02555 (/IGI) Q02555 (/IGI) Q02555 (/IGI) Q02555 (/IGI) Q02555 (/IGI) Q02555 (/IGI) Q02555 (/IGI)
Regulation of fungal-type cell wall organization GO:0060237
Any process that modulates the rate, frequency or extent of the formation, arrangement of constituent parts, or disassembly of the fungal-type cell wall.
8 Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP) Q02555 (/IMP)
Endonucleolytic cleavage involved in rRNA processing GO:0000478
Any endonucleolytic cleavage involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. Some endonucleolytic cleavages produce the mature end, while others are a step in the process of generating the mature end from the pre-rRNA.
1 P22192 (/IDA)
RNA metabolic process GO:0016070
The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
1 P22192 (/IDA)
Production of siRNA involved in RNA interference GO:0030422
Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference.
1 A0A1D8PM62 (/IDA)
U2 snRNA 3'-end processing GO:0034474
Any process involved in forming the mature 3' end of a U2 snRNA molecule.
1 P22192 (/IDA)
U2 snRNA 3'-end processing GO:0034474
Any process involved in forming the mature 3' end of a U2 snRNA molecule.
1 P22192 (/IMP)
Production of miRNAs involved in gene silencing by miRNA GO:0035196
Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein, or by increasing the degradation of non-protein-coding RNA transcripts.
1 A0A1D8PM62 (/TAS)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
147 P0A7Y0 (/IDA) P0A7Y0 (/IDA) P0A7Y0 (/IDA) P0A7Y0 (/IDA) P0A7Y0 (/IDA) P0A7Y0 (/IDA) P0A7Y0 (/IDA) P0A7Y0 (/IDA) P0A7Y0 (/IDA) P0A7Y0 (/IDA)
(137 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
8 Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
8 Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA) Q02555 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P22192 (/HDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 P22192 (/ISO)
CATH-Gene3D is a Global Biodata Core Resource Learn more...