The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Receptor activity modifying family
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 2: Receptor activity-modifying protein 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Coreceptor activity GO:0015026
Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity.
3 Q9JJ74 (/IDA) Q9WTJ5 (/IDA) Q9WTJ5 (/IDA)
Calcitonin gene-related peptide receptor activity GO:0001635
Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity.
2 Q9WTJ5 (/ISO) Q9WTJ5 (/ISO)
Coreceptor activity GO:0015026
Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity.
2 Q9WTJ5 (/ISO) Q9WTJ5 (/ISO)
Amylin receptor activity GO:0097643
Combining with amylin to initiate a change in cell activity.
2 Q9WTJ5 (/ISO) Q9WTJ5 (/ISO)
Calcitonin gene-related peptide binding GO:1990407
Interacting selectively and non-covalently with calcitonin gene-related peptide (CGRP).
2 Q9WTJ5 (/ISO) Q9WTJ5 (/ISO)
Calcitonin gene-related peptide receptor activity GO:0001635
Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity.
1 O60894 (/IPI)
G protein-coupled receptor binding GO:0001664
Interacting selectively and non-covalently with a G protein-coupled receptor.
1 Q9JJ74 (/NAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 O60894 (/IPI)
Coreceptor activity GO:0015026
Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity.
1 Q9JJ74 (/IMP)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 Q9JJ74 (/NAS)
Amylin receptor activity GO:0097643
Combining with amylin to initiate a change in cell activity.
1 O60894 (/IPI)
Calcitonin gene-related peptide binding GO:1990407
Interacting selectively and non-covalently with calcitonin gene-related peptide (CGRP).
1 O60894 (/IPI)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
2 Q9WTJ5 (/ISO) Q9WTJ5 (/ISO)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q9WTJ5 (/ISO) Q9WTJ5 (/ISO)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 Q9WTJ5 (/IPI) Q9WTJ5 (/IPI)
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
2 O60894 (/IPI) Q867C0 (/IPI)
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
2 Q9WTJ5 (/ISO) Q9WTJ5 (/ISO)
Protein transport GO:0015031
The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q9WTJ5 (/ISO) Q9WTJ5 (/ISO)
Receptor internalization GO:0031623
A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
2 O60894 (/IDA) Q9JJ74 (/IDA)
Receptor internalization GO:0031623
A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
2 Q9WTJ5 (/ISO) Q9WTJ5 (/ISO)
Positive regulation of protein glycosylation GO:0060050
Any process that activates or increases the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
2 Q9WTJ5 (/ISO) Q9WTJ5 (/ISO)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
2 Q9WTJ5 (/ISO) Q9WTJ5 (/ISO)
Amylin receptor signaling pathway GO:0097647
A series of molecular signals initiated by an extracellular amylin combining with a dimeric amylin receptor on the surface of the target cell.
2 Q9WTJ5 (/ISO) Q9WTJ5 (/ISO)
Calcitonin gene-related peptide receptor signaling pathway GO:1990408
A series of molecular signals initiated by an extracellular calcitonin gene-related peptide (CGRP) combining with a calcitonin gene-related peptide receptor on the surface of the target cell. Calcitonin gene-related peptide receptors may form dimers, trimers or tetramers.
2 O60894 (/IPI) Q867C0 (/IPI)
Calcitonin gene-related peptide receptor signaling pathway GO:1990408
A series of molecular signals initiated by an extracellular calcitonin gene-related peptide (CGRP) combining with a calcitonin gene-related peptide receptor on the surface of the target cell. Calcitonin gene-related peptide receptors may form dimers, trimers or tetramers.
2 Q9WTJ5 (/ISO) Q9WTJ5 (/ISO)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
1 O60894 (/IDA)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 O60894 (/IDA)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
1 O60894 (/TAS)
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
1 O60894 (/IDA)
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
1 O60894 (/IGI)
Protein transport GO:0015031
The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 O60894 (/IDA)
Positive regulation of protein glycosylation GO:0060050
Any process that activates or increases the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
1 O60894 (/IDA)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
1 O60894 (/IDA)
Amylin receptor signaling pathway GO:0097647
A series of molecular signals initiated by an extracellular amylin combining with a dimeric amylin receptor on the surface of the target cell.
1 O60894 (/IDA)
Amylin receptor signaling pathway GO:0097647
A series of molecular signals initiated by an extracellular amylin combining with a dimeric amylin receptor on the surface of the target cell.
1 O60894 (/IGI)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 Q9WTJ5 (/ISO) Q9WTJ5 (/ISO)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
2 Q9WTJ5 (/ISO) Q9WTJ5 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q9WTJ5 (/ISO) Q9WTJ5 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 Q9WTJ5 (/ISO) Q9WTJ5 (/ISO)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2 Q9WTJ5 (/ISO) Q9WTJ5 (/ISO)
Amylin receptor complex 1 GO:0150056
A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 1. Amylin receptor complex 1 (AMY1) also serves as a receptor for the calcitonin related peptide (CGRP) and adrenomedullin (AM/ADM).
2 Q9WTJ5 (/ISO) Q9WTJ5 (/ISO)
CGRP receptor complex GO:1990406
A transmembrane, G protein-coupled signalling receptor complex recognized by calcitonin gene-related peptides (CGRP).
2 Q9WTJ5 (/ISO) Q9WTJ5 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q9JJ74 (/IDA)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
1 O60894 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O60894 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O60894 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 O60894 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 O60894 (/IDA)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 O60894 (/IDA)
Amylin receptor complex 1 GO:0150056
A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 1. Amylin receptor complex 1 (AMY1) also serves as a receptor for the calcitonin related peptide (CGRP) and adrenomedullin (AM/ADM).
1 O60894 (/IDA)
CGRP receptor complex GO:1990406
A transmembrane, G protein-coupled signalling receptor complex recognized by calcitonin gene-related peptides (CGRP).
1 O60894 (/IDA)
CATH-Gene3D is a Global Biodata Core Resource Learn more...