The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"DUF3349, helical bundle
".
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"The most representative domain was characterised in Rv0543c - a monomeric bundle of five alpha-helices rigidly held together by a largely conserved group of hydrophobic amino acid side chains. It irreversibly unfolds upon heating with Tm of 62.5C. The fold observed for Rv0543c may be unique for Rv0543c and the other members of the DUF3349 superfamily.
According to literature, the DUF3349 proteins are predicted to be good drug targets because they are predominately in the Mycobacterium and Rhodococcus bacterial species.
DOI:10.1016/j.abb.2010.12.001, DUF3349, PFAM:PF11829, INTERPRO:IPR021784
| Structures | |
|---|---|
| Domains: | 3 |
| Domain clusters (>95% seq id): | 3 |
| Domain clusters (>35% seq id): | 3 |
| Unique PDBs: | 3 |
| Alignments | |
| Structural Clusters (5A): | 1 |
| Structural Clusters (9A): | 1 |
| FunFam Clusters: | 0 |
| Function | |
| Unique EC: | |
| Unique GO: | |
| Taxonomy | |
| Unique Species: | 283 |