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CATH Superfamily 1.10.1410.20

2'-5'-oligoadenylate synthetase 1, domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
2'-5'-oligoadenylate synthetase 1, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: 2'-5'-oligoadenylate synthetase 3

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2'-5' oligoadenylate synthase. [EC: 2.7.7.84]
3 ATP = pppA2'p5'A2'p5'A + 2 diphosphate.
  • The enzyme is activated by binding to double-stranded RNA.
  • The resulting product binds to and activates RNase L, which subsequently degrades the RNA.
  • Oligoadenylates of chain lengths 2, 4 and 5 are also produced.
  • The dimer does not have any known biological activity.
 6 Q5MYT7 Q5MYT7 Q8VI93 Q8VI93 Q9Y6K5 Q9Y6K5
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