View in Gene3D

CATH Superfamily 1.10.1370.30

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 11: Angiotensin-converting enzyme

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Peptidyl-dipeptidase A. [EC: 3.4.15.1]
Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.
  • Cl(-)-dependent.
  • A glycoprotein that is generally membrane-bound.
  • Active at neutral pH.
  • Only single dipeptides are released from angiotensin I and bradykinin because of the lack of activity on bonds involving proline.
  • Belongs to peptidase family M2.
 4 M9PCE8 M9PCE8 Q9VLJ6 Q9VLJ6