CATH Superfamily 1.10.132.70
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 15: Telomerase reverse transcriptase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Telomerase RNA reverse transcriptase activity GO:0003721
Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template.
|
1 | O13339 (/IDA) |
|
Telomerase RNA reverse transcriptase activity GO:0003721
Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template.
|
1 | O13339 (/IMP) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
1 | O13339 (/IPI) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | O13339 (/IPI) |
|
Telomeric DNA binding GO:0042162
Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end.
|
1 | O13339 (/ISO) |
|
Telomerase RNA binding GO:0070034
Interacting selectively and non-covalently with the telomerase RNA template.
|
1 | O13339 (/IPI) |
There are 5 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Telomere maintenance GO:0000723
Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.
|
1 | O13339 (/IMP) |
|
Telomere maintenance via telomerase GO:0007004
The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase.
|
1 | O13339 (/IDA) |
|
Telomere maintenance via telomerase GO:0007004
The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase.
|
1 | O13339 (/IMP) |
|
DNA strand elongation GO:0022616
The DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand.
|
1 | O13339 (/IDA) |
|
Telomerase catalytic core complex assembly GO:1904868
The aggregation, arrangement and bonding together of a set of components to form a telomerase catalytic core complex.
|
1 | O13339 (/EXP) |
There are 5 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Telomerase catalytic core complex GO:0000333
The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition.
|
1 | O13339 (/IDA) |
|
Chromosome, telomeric region GO:0000781
The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins.
|
1 | O13339 (/IDA) |
|
Telomere cap complex GO:0000782
A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome.
|
1 | O13339 (/IDA) |
|
Nuclear chromosome, telomeric region GO:0000784
The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.
|
1 | O13339 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | O13339 (/HDA) |