The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: DNA topoisomerase I

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA topoisomerase type I activity GO:0003917
Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
9 P04786 (/IDA) P04786 (/IDA) P04786 (/IDA) P04786 (/IDA) P04786 (/IDA) P04786 (/IDA) P07799 (/IDA) Q5BGS7 (/IDA) Q5BGS7 (/IDA)
DNA topoisomerase type I activity GO:0003917
Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
8 A0A1D8PPI2 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P07799 (/IMP)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 P07799 (/IDA)
DNA topoisomerase type I activity GO:0003917
Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
1 A0A1D8PPI2 (/IGI)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA topological change GO:0006265
The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
8 P04786 (/IDA) P04786 (/IDA) P04786 (/IDA) P04786 (/IDA) P04786 (/IDA) P04786 (/IDA) Q5BGS7 (/IDA) Q5BGS7 (/IDA)
DNA topological change GO:0006265
The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
7 P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P07799 (/IMP)
Regulation of mitotic recombination GO:0000019
Any process that modulates the frequency, rate or extent of DNA recombination during mitosis.
6 P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP)
Chromatin silencing at rDNA GO:0000183
Repression of transcription of ribosomal DNA by altering the structure of chromatin.
6 P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP)
DNA strand elongation involved in DNA replication GO:0006271
The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication.
6 P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP)
Chromatin assembly or disassembly GO:0006333
The formation or destruction of chromatin structures.
6 P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
6 P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP)
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
6 P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP)
Mitotic chromosome condensation GO:0007076
The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.
6 P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP)
Nuclear migration GO:0007097
The directed movement of the nucleus to a specific location within a cell.
6 P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP)
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
1 P07799 (/IGI)
Chromatin assembly or disassembly GO:0006333
The formation or destruction of chromatin structures.
1 P07799 (/ISO)
Mitotic chromosome condensation GO:0007076
The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.
1 P07799 (/ISO)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
1 A0A1D8PPI2 (/IMP)
Hyphal growth GO:0030448
Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls.
1 A0A1D8PPI2 (/IMP)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
7 P04786 (/IDA) P04786 (/IDA) P04786 (/IDA) P04786 (/IDA) P04786 (/IDA) P04786 (/IDA) P07799 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
6 P04786 (/IPI) P04786 (/IPI) P04786 (/IPI) P04786 (/IPI) P04786 (/IPI) P04786 (/IPI)
Replication fork protection complex GO:0031298
A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling.
6 P04786 (/IDA) P04786 (/IDA) P04786 (/IDA) P04786 (/IDA) P04786 (/IDA) P04786 (/IDA)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 P07799 (/NAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P07799 (/HDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 P07799 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P07799 (/IDA)
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