The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Phosphodiesterase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
3',5'-cyclic-AMP phosphodiesterase activity GO:0004115
Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.
2 E9Q4S1 (/IDA) O88502 (/IDA)
3',5'-cyclic-AMP phosphodiesterase activity GO:0004115
Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.
2 O60658 (/IMP) O95263 (/IMP)
3',5'-cyclic-AMP phosphodiesterase activity GO:0004115
Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.
2 E9Q4S1 (/ISO) O88502 (/ISO)
3',5'-cyclic-AMP phosphodiesterase activity GO:0004115
Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.
1 Q6NNF2 (/ISM)
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
1 O60658 (/IPI)
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
1 O88502 (/ISO)
3',5'-cyclic-GMP phosphodiesterase activity GO:0047555
Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.
1 O60658 (/IDA)
3',5'-cyclic-GMP phosphodiesterase activity GO:0047555
Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.
1 O88502 (/ISO)

There are 22 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
3 O60658 (/IMP) O88502 (/IMP) Q6NNF2 (/IMP)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 O60658 (/TAS) O95263 (/TAS)
Cellular response to epidermal growth factor stimulus GO:0071364
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
2 O60658 (/IMP) O88502 (/IMP)
Negative regulation of hydrogen peroxide-induced cell death GO:1903206
Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced cell death.
2 O60658 (/IMP) Q6NNF2 (/IMP)
Behavioral fear response GO:0001662
An acute behavioral change resulting from a perceived external threat.
1 E9Q4S1 (/IMP)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 O60658 (/IMP)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 O88502 (/ISO)
Mesoderm development GO:0007498
The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
1 Q6NNF2 (/IEP)
Visual learning GO:0008542
Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.
1 E9Q4S1 (/IMP)
Operant conditioning GO:0035106
Learning to anticipate future events on the basis of past experience with the consequences of one's own behavior.
1 E9Q4S1 (/IMP)
CAMP metabolic process GO:0046058
The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
1 Q6NNF2 (/ISM)
Negative regulation of insulin secretion GO:0046676
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
1 Q76KC5 (/IMP)
Negative regulation of insulin secretion GO:0046676
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
1 E9Q4S1 (/ISO)
Neuromuscular process controlling balance GO:0050885
Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors.
1 E9Q4S1 (/IMP)
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
1 O60658 (/IMP)
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
1 O88502 (/ISO)
Negative regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061179
Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
1 Q76KC5 (/IMP)
Negative regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061179
Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
1 E9Q4S1 (/ISO)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 O88502 (/ISO)
Cellular response to epidermal growth factor stimulus GO:0071364
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
1 O88502 (/ISO)
Negative regulation of steroid hormone biosynthetic process GO:0090032
Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones.
1 E9Q4S1 (/IMP)
Negative regulation of hydrogen peroxide-induced cell death GO:1903206
Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced cell death.
1 O88502 (/ISO)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 O60658 (/TAS) O95263 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 O60658 (/HDA)
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