The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 11: Phosphodiesterase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity GO:0048101
Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. The reaction is calmodulin and calcium-sensitive.
3 A0A0G2JZX9 (/IMP) A0A0G2K2K1 (/IMP) Q9EPR9 (/IMP)
Calmodulin-dependent cyclic-nucleotide phosphodiesterase activity GO:0004117
Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is regulated by calmodulin.
2 P14100 (/IDA) P14100 (/IDA)
Calmodulin-dependent cyclic-nucleotide phosphodiesterase activity GO:0004117
Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is regulated by calmodulin.
2 P54750 (/TAS) P54750 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P14100 (/IPI) P14100 (/IPI)
Calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity GO:0048101
Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. The reaction is calmodulin and calcium-sensitive.
2 P14100 (/IDA) P14100 (/IDA)
Calmodulin-dependent cyclic-nucleotide phosphodiesterase activity GO:0004117
Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is regulated by calmodulin.
1 Q61481 (/ISO)
Calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity GO:0048101
Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. The reaction is calmodulin and calcium-sensitive.
1 Q61481 (/ISO)

There are 9 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Pronephros development GO:0048793
The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life.
4 A0A0C5BKQ6 (/IGI) A0A0C5C3Y9 (/IGI) A0A2R8RXK7 (/IGI) E7F6Z8 (/IGI)
Pronephros development GO:0048793
The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life.
4 A0A0C5BKQ6 (/IMP) A0A0C5C3Y9 (/IMP) A0A2R8RXK7 (/IMP) E7F6Z8 (/IMP)
Regulation of smooth muscle cell apoptotic process GO:0034391
Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process.
3 A0A0G2JZX9 (/IMP) A0A0G2K2K1 (/IMP) Q9EPR9 (/IMP)
CGMP catabolic process GO:0046069
The chemical reactions and pathways resulting in the breakdown of cyclic GMP, guanosine 3',5'-phosphate.
3 A0A0G2JZX9 (/IMP) A0A0G2K2K1 (/IMP) Q9EPR9 (/IMP)
Regulation of smooth muscle cell proliferation GO:0048660
Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation.
3 A0A0G2JZX9 (/IMP) A0A0G2K2K1 (/IMP) Q9EPR9 (/IMP)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 P54750 (/TAS) P54750 (/TAS)
Regulation of smooth muscle cell apoptotic process GO:0034391
Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process.
1 Q61481 (/ISO)
CGMP catabolic process GO:0046069
The chemical reactions and pathways resulting in the breakdown of cyclic GMP, guanosine 3',5'-phosphate.
1 Q61481 (/ISO)
Regulation of smooth muscle cell proliferation GO:0048660
Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation.
1 Q61481 (/ISO)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 A0A0G2JZX9 (/IDA) A0A0G2K2K1 (/IDA) Q9EPR9 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 A0A0G2JZX9 (/IDA) A0A0G2K2K1 (/IDA) Q9EPR9 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
3 A0A0G2JZX9 (/IDA) A0A0G2K2K1 (/IDA) Q9EPR9 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P54750 (/TAS) P54750 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q61481 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q61481 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q61481 (/ISO)
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