The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Methionine synthase domain
".
FunFam 1: Methionine synthase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 15 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Methionine synthase activity GO:0008705
Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine.
|
26 |
G3V8A4 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
(16 more) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
23 |
P13009 (/IMP)
P13009 (/IMP)
P13009 (/IMP)
P13009 (/IMP)
P13009 (/IMP)
P13009 (/IMP)
P13009 (/IMP)
P13009 (/IMP)
P13009 (/IMP)
P13009 (/IMP)
(13 more) |
|
Protein methyltransferase activity GO:0008276
Catalysis of the transfer of a methyl group (CH3-) to a protein.
|
23 |
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
(13 more) |
|
Cobalamin binding GO:0031419
Interacting selectively and non-covalently with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
|
23 |
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
(13 more) |
|
Methionine synthase activity GO:0008705
Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine.
|
15 |
Q48IG8 (/ISS)
Q48IG8 (/ISS)
Q48IG8 (/ISS)
Q54P92 (/ISS)
Q608E7 (/ISS)
Q881Z7 (/ISS)
Q881Z7 (/ISS)
Q8EI23 (/ISS)
Q9KUW9 (/ISS)
Q9KUW9 (/ISS)
(5 more) |
|
Methionine synthase activity GO:0008705
Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine.
|
3 | A6H5Y3 (/IMP) Q99707 (/IMP) Q9Z2Q4 (/IMP) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q99707 (/IPI) |
|
Folic acid binding GO:0005542
Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
|
1 | Q9Z2Q4 (/IDA) |
|
Folic acid binding GO:0005542
Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
|
1 | A6H5Y3 (/ISO) |
|
Methyltransferase activity GO:0008168
Catalysis of the transfer of a methyl group to an acceptor molecule.
|
1 | Q9Z2Q4 (/IDA) |
|
Methyltransferase activity GO:0008168
Catalysis of the transfer of a methyl group to an acceptor molecule.
|
1 | A6H5Y3 (/ISO) |
|
Methionine synthase activity GO:0008705
Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine.
|
1 | A6H5Y3 (/ISO) |
|
Amino acid binding GO:0016597
Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.
|
1 | Q9Z2Q4 (/IDA) |
|
Amino acid binding GO:0016597
Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.
|
1 | A6H5Y3 (/ISO) |
|
Cobalamin binding GO:0031419
Interacting selectively and non-covalently with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
|
1 | Q9Z2Q4 (/TAS) |
There are 32 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Methionine biosynthetic process GO:0009086
The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
|
24 |
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
(14 more) |
|
Homocysteine metabolic process GO:0050667
The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine.
|
24 |
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
(14 more) |
|
Tetrahydrofolate interconversion GO:0035999
The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules.
|
23 |
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
(13 more) |
|
Methionine biosynthetic process GO:0009086
The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
|
15 |
Q48IG8 (/ISS)
Q48IG8 (/ISS)
Q48IG8 (/ISS)
Q54P92 (/ISS)
Q608E7 (/ISS)
Q881Z7 (/ISS)
Q881Z7 (/ISS)
Q8EI23 (/ISS)
Q9KUW9 (/ISS)
Q9KUW9 (/ISS)
(5 more) |
|
Methionine biosynthetic process GO:0009086
The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
|
2 | A6H5Y3 (/IMP) Q99707 (/IMP) |
|
Sulfur amino acid metabolic process GO:0000096
The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine.
|
1 | Q99707 (/TAS) |
|
DNA methylation GO:0006306
The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.
|
1 | G3V8A4 (/IC) |
|
Protein methylation GO:0006479
The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.
|
1 | Q9Z2Q4 (/IDA) |
|
Protein methylation GO:0006479
The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.
|
1 | A6H5Y3 (/ISO) |
|
Methionine metabolic process GO:0006555
The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
|
1 | Q9Z2Q4 (/IMP) |
|
Methionine metabolic process GO:0006555
The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
|
1 | A6H5Y3 (/ISO) |
|
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
|
1 | Q99707 (/TAS) |
|
Methionine biosynthetic process GO:0009086
The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
|
1 | A6H5Y3 (/ISO) |
|
Cobalamin metabolic process GO:0009235
The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
|
1 | Q99707 (/IMP) |
|
Cobalamin metabolic process GO:0009235
The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
|
1 | A6H5Y3 (/ISO) |
|
Cobalamin metabolic process GO:0009235
The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
|
1 | Q99707 (/TAS) |
|
Axon regeneration GO:0031103
The regrowth of axons following their loss or damage.
|
1 | G3V8A4 (/IMP) |
|
Axon regeneration GO:0031103
The regrowth of axons following their loss or damage.
|
1 | A6H5Y3 (/ISO) |
|
Axon regeneration GO:0031103
The regrowth of axons following their loss or damage.
|
1 | Q99707 (/ISS) |
|
Methylation GO:0032259
The process in which a methyl group is covalently attached to a molecule.
|
1 | Q99707 (/TAS) |
|
Tetrahydrofolate metabolic process GO:0046653
The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.
|
1 | Q9Z2Q4 (/IDA) |
|
Tetrahydrofolate metabolic process GO:0046653
The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.
|
1 | Q9Z2Q4 (/IMP) |
|
Tetrahydrofolate metabolic process GO:0046653
The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.
|
1 | A6H5Y3 (/ISO) |
|
Response to axon injury GO:0048678
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus.
|
1 | G3V8A4 (/IDA) |
|
Response to axon injury GO:0048678
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus.
|
1 | A6H5Y3 (/ISO) |
|
Response to axon injury GO:0048678
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus.
|
1 | Q99707 (/ISS) |
|
Homocysteine metabolic process GO:0050667
The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine.
|
1 | Q9Z2Q4 (/IMP) |
|
Homocysteine metabolic process GO:0050667
The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine.
|
1 | A6H5Y3 (/ISO) |
|
Cellular response to methionine GO:0061431
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methionine stimulus.
|
1 | Q9Z2Q4 (/IEP) |
|
Cellular response to nitric oxide GO:0071732
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus.
|
1 | G3V8A4 (/IDA) |
|
Cellular response to nitric oxide GO:0071732
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus.
|
1 | A6H5Y3 (/ISO) |
|
Cellular response to nitric oxide GO:0071732
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus.
|
1 | Q99707 (/ISS) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
24 |
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
(14 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
23 |
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
P13009 (/IDA)
(13 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | A6H5Y3 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q99707 (/TAS) |