The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Lyase 2-enoyl-coa Hydratase, Chain A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Probable enoyl-CoA hydratase, mitochondrial

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Enoyl-CoA hydratase activity GO:0004300
Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O.
35 P14604 (/IDA) P30084 (/IDA) P76082 (/IDA) P76082 (/IDA) P76082 (/IDA) P76082 (/IDA) P76082 (/IDA) P76082 (/IDA) P76082 (/IDA) P76082 (/IDA)
(25 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
32 P30084 (/IPI) P76082 (/IPI) P76082 (/IPI) P76082 (/IPI) P76082 (/IPI) P76082 (/IPI) P76082 (/IPI) P76082 (/IPI) P76082 (/IPI) P76082 (/IPI)
(22 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
31 P76082 (/IDA) P76082 (/IDA) P76082 (/IDA) P76082 (/IDA) P76082 (/IDA) P76082 (/IDA) P76082 (/IDA) P76082 (/IDA) P76082 (/IDA) P76082 (/IDA)
(21 more)
Enoyl-CoA hydratase activity GO:0004300
Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O.
7 Q54HG7 (/ISS) Q58DM8 (/ISS) Q5LWT8 (/ISS) Q5R646 (/ISS) Q7JR58 (/ISS) Q8BH95 (/ISS) Q9JLZ3 (/ISS)
MRNA 3'-UTR binding GO:0003730
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
2 Q54HG7 (/ISS) Q9JLZ3 (/ISS)
Catalytic activity GO:0003824
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
2 Q38BK0 (/ISM) Q38BK0 (/ISM)
Enoyl-CoA hydratase activity GO:0004300
Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O.
2 Q8BH95 (/ISO) Q9JLZ3 (/ISO)
3-hydroxypropionyl-CoA dehydratase activity GO:0043956
Catalysis of the reaction: 3-hydroxypropionyl-CoA = acrylyl-CoA + H2O.
2 A4YI89 (/IDA) A4YI89 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q9JLZ3 (/IDA)
MRNA 3'-UTR binding GO:0003730
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
1 Q13825 (/IDA)
MRNA 3'-UTR binding GO:0003730
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
1 Q9JLZ3 (/ISO)
Enoyl-CoA hydratase activity GO:0004300
Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O.
1 P14604 (/IMP)
Enoyl-CoA hydratase activity GO:0004300
Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O.
1 C8V3K8 (/ISA)
Enoyl-CoA hydratase activity GO:0004300
Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O.
1 P30084 (/TAS)
Methylglutaconyl-CoA hydratase activity GO:0004490
Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H(2)O.
1 F4JML5 (/IDA)
Methylglutaconyl-CoA hydratase activity GO:0004490
Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H(2)O.
1 F4JML5 (/IMP)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phenylacetate catabolic process GO:0010124
The chemical reactions and pathways resulting in the breakdown of phenylacetate.
31 P76082 (/IMP) P76082 (/IMP) P76082 (/IMP) P76082 (/IMP) P76082 (/IMP) P76082 (/IMP) P76082 (/IMP) P76082 (/IMP) P76082 (/IMP) P76082 (/IMP)
(21 more)
Fatty acid beta-oxidation GO:0006635
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
5 P14604 (/ISS) Q58DM8 (/ISS) Q5R646 (/ISS) Q7JR58 (/ISS) Q8BH95 (/ISS)
Fatty acid beta-oxidation GO:0006635
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
2 P14604 (/TAS) P30084 (/TAS)
Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288
A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability.
1 Q9JLZ3 (/TAS)
Isoleucine catabolic process GO:0006550
The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.
1 C8V3K8 (/IMP)
Valine catabolic process GO:0006574
The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid.
1 C8V3K8 (/IMP)
Fatty acid beta-oxidation GO:0006635
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
1 P30084 (/IDA)
Fatty acid beta-oxidation GO:0006635
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
1 P14604 (/IMP)
Fatty acid beta-oxidation GO:0006635
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
1 Q8BH95 (/ISO)
Fatty acid catabolic process GO:0009062
The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
1 Q5LWT8 (/ISS)
Branched-chain amino acid catabolic process GO:0009083
The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.
1 F4JML5 (/IMP)
Branched-chain amino acid catabolic process GO:0009083
The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.
1 Q13825 (/TAS)
Cold acclimation GO:0009631
Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures.
1 A1Z934 (/IEP)
Short-chain fatty acid catabolic process GO:0019626
The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of less than C6.
1 C8V3K8 (/IMP)
Fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539
A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
1 C8V3K8 (/ISA)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
13 P9WNN9 (/HDA) P9WNN9 (/HDA) P9WNN9 (/HDA) P9WNN9 (/HDA) P9WNN9 (/HDA) P9WNN9 (/HDA) P9WNN9 (/HDA) P9WNN9 (/HDA) P9WNN9 (/HDA) P9WNN9 (/HDA)
(3 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
13 P9WNN9 (/HDA) P9WNN9 (/HDA) P9WNN9 (/HDA) P9WNN9 (/HDA) P9WNN9 (/HDA) P9WNN9 (/HDA) P9WNN9 (/HDA) P9WNN9 (/HDA) P9WNN9 (/HDA) P9WNN9 (/HDA)
(3 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
5 C8V3K8 (/IDA) F4JML5 (/IDA) P14604 (/IDA) P30084 (/IDA) Q9JLZ3 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 P34559 (/HDA) Q7JR58 (/HDA) Q8BH95 (/HDA) Q9JLZ3 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 Q13825 (/ISS) Q1ZXF1 (/ISS) Q54HG7 (/ISS) Q9JLZ3 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q38BK0 (/RCA) Q38BK0 (/RCA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P14604 (/TAS) P30084 (/TAS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 P30084 (/TAS) Q13825 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q8BH95 (/ISO)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 Q7JR58 (/ISS)
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