The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Homeodomain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 98: Transcription factor LBX1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 Q7JMT6 (/IDA) Q7KS77 (/IDA) Q7KS77 (/IDA) Q9VDA1 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P52955 (/IPI) Q804R0 (/IPI) Q9DD91 (/IPI)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
2 Q0P4H6 (/ISS) Q2PYN8 (/ISS)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 P52954 (/ISA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 P52954 (/ISM)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 P52954 (/NAS)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 P52955 (/IDA)

There are 38 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
8 A0A0B4KH37 (/IMP) P91626 (/IMP) Q24416 (/IMP) Q7JMT6 (/IMP) Q7KS77 (/IMP) Q7KS77 (/IMP) Q9VDA1 (/IMP) Q9VDA2 (/IMP)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
8 A0A0B4KH37 (/NAS) P91626 (/NAS) Q24416 (/NAS) Q7JMT6 (/NAS) Q7KS77 (/NAS) Q7KS77 (/NAS) Q9VDA1 (/NAS) Q9VDA2 (/NAS)
Imaginal disc-derived leg morphogenesis GO:0007480
The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster.
8 A0A0B4KH37 (/IGI) P91626 (/IGI) Q24416 (/IGI) Q7JMT6 (/IGI) Q7KS77 (/IGI) Q7KS77 (/IGI) Q9VDA1 (/IGI) Q9VDA2 (/IGI)
Genital disc morphogenesis GO:0007483
The process in which the anatomical structures derived from the genital disc are generated and organized. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut.
8 A0A0B4KH37 (/IMP) P91626 (/IMP) Q24416 (/IMP) Q7JMT6 (/IMP) Q7KS77 (/IMP) Q7KS77 (/IMP) Q9VDA1 (/IMP) Q9VDA2 (/IMP)
Mesodermal cell fate specification GO:0007501
The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
8 A0A0B4KH37 (/TAS) P91626 (/TAS) Q24416 (/TAS) Q7JMT6 (/TAS) Q7KS77 (/TAS) Q7KS77 (/TAS) Q9VDA1 (/TAS) Q9VDA2 (/TAS)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
8 A0A0B4KH37 (/TAS) P91626 (/TAS) Q24416 (/TAS) Q7JMT6 (/TAS) Q7KS77 (/TAS) Q7KS77 (/TAS) Q9VDA1 (/TAS) Q9VDA2 (/TAS)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
8 A0A0B4KH37 (/TAS) P91626 (/TAS) Q24416 (/TAS) Q7JMT6 (/TAS) Q7KS77 (/TAS) Q7KS77 (/TAS) Q9VDA1 (/TAS) Q9VDA2 (/TAS)
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
8 A0A0B4KH37 (/IGI) P91626 (/IGI) Q24416 (/IGI) Q7JMT6 (/IGI) Q7KS77 (/IGI) Q7KS77 (/IGI) Q9VDA1 (/IGI) Q9VDA2 (/IGI)
Myoblast fusion GO:0007520
A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
8 A0A0B4KH37 (/IGI) P91626 (/IGI) Q24416 (/IGI) Q7JMT6 (/IGI) Q7KS77 (/IGI) Q7KS77 (/IGI) Q9VDA1 (/IGI) Q9VDA2 (/IGI)
Epidermis development GO:0008544
The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
8 A0A0B4KH37 (/IMP) P91626 (/IMP) Q24416 (/IMP) Q7JMT6 (/IMP) Q7KS77 (/IMP) Q7KS77 (/IMP) Q9VDA1 (/IMP) Q9VDA2 (/IMP)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
8 A0A0B4KH37 (/IGI) P91626 (/IGI) Q24416 (/IGI) Q7JMT6 (/IGI) Q7KS77 (/IGI) Q7KS77 (/IGI) Q9VDA1 (/IGI) Q9VDA2 (/IGI)
Regulation of cell fate specification GO:0042659
Any process that mediates the adoption of a specific fate by a cell.
8 A0A0B4KH37 (/IMP) P91626 (/IMP) Q24416 (/IMP) Q7JMT6 (/IMP) Q7KS77 (/IMP) Q7KS77 (/IMP) Q9VDA1 (/IMP) Q9VDA2 (/IMP)
Regulation of neuron differentiation GO:0045664
Any process that modulates the frequency, rate or extent of neuron differentiation.
8 A0A0B4KH37 (/IMP) P91626 (/IMP) Q24416 (/IMP) Q7JMT6 (/IMP) Q7KS77 (/IMP) Q7KS77 (/IMP) Q9VDA1 (/IMP) Q9VDA2 (/IMP)
Myoblast proliferation GO:0051450
The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
8 A0A0B4KH37 (/IGI) P91626 (/IGI) Q24416 (/IGI) Q7JMT6 (/IGI) Q7KS77 (/IGI) Q7KS77 (/IGI) Q9VDA1 (/IGI) Q9VDA2 (/IGI)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
4 Q7JMT6 (/IEP) Q7KS77 (/IEP) Q7KS77 (/IEP) Q9VDA1 (/IEP)
Ventral cord development GO:0007419
The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms.
4 Q7JMT6 (/HMP) Q7KS77 (/HMP) Q7KS77 (/HMP) Q9VDA1 (/HMP)
Regulation of myoblast fusion GO:1901739
Any process that modulates the frequency, rate or extent of myoblast fusion.
4 Q7JMT6 (/IMP) Q7KS77 (/IMP) Q7KS77 (/IMP) Q9VDA1 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
2 Q0P4H6 (/ISS) Q2PYN8 (/ISS)
Muscle cell development GO:0055001
The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate.
2 Q804R0 (/IMP) Q9DD91 (/IMP)
Regulation of canonical Wnt signaling pathway GO:0060828
Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
2 Q804R0 (/IMP) Q9DD91 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q2PYN8 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q0P4H6 (/ISS)
Heart looping GO:0001947
The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
1 P52955 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 P52955 (/IDA)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
1 Q2PYN8 (/IMP)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
1 Q0P4H6 (/ISS)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 P52955 (/IMP)
Anatomical structure morphogenesis GO:0009653
The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
1 P52954 (/TAS)
Spinal cord motor neuron differentiation GO:0021522
The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.
1 P52955 (/IGI)
Regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification GO:0021920
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of neuronal precursors to association neurons in the dorsal spinal cord.
1 P52955 (/IMP)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
1 P52955 (/IMP)
Neuron fate commitment GO:0048663
The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron.
1 P52955 (/IMP)
Neuron fate determination GO:0048664
The process in which a cell becomes capable of differentiating autonomously into a neuron regardless of its environment; upon determination, the cell fate cannot be reversed.
1 P52955 (/IGI)
Neuron fate determination GO:0048664
The process in which a cell becomes capable of differentiating autonomously into a neuron regardless of its environment; upon determination, the cell fate cannot be reversed.
1 P52955 (/IMP)
Myoblast proliferation GO:0051450
The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
1 Q2PYN8 (/IMP)
Myoblast proliferation GO:0051450
The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
1 Q0P4H6 (/ISS)
Convergent extension GO:0060026
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis.
1 E7FDX5 (/IGI)
Convergent extension GO:0060026
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis.
1 E7FDX5 (/IMP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 A0A0B4KH37 (/IDA) P91626 (/IDA) Q24416 (/IDA) Q7JMT6 (/IDA) Q7KS77 (/IDA) Q7KS77 (/IDA) Q9VDA1 (/IDA) Q9VDA2 (/IDA)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
2 Q0P4H6 (/ISS) Q2PYN8 (/ISS)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
1 P52955 (/IDA)
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