The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Homeodomain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 88: DNA-binding transcriptional regulator NtrC

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphorelay response regulator activity GO:0000156
Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
95 Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS)
(85 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
57 P0AFB8 (/IPI) P0AFB8 (/IPI) P0AFB8 (/IPI) P0AFB8 (/IPI) P0AFB8 (/IPI) P0AFB8 (/IPI) P0AFB8 (/IPI) P0AFB8 (/IPI) P0AFB8 (/IPI) P0AFB8 (/IPI)
(47 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
7 Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
7 Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
7 Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
7 Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
7 Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI)

There are 5 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphorelay signal transduction system GO:0000160
A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
95 Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS)
(85 more)
Regulation of nitrogen utilization GO:0006808
Any process that modulates the frequency, rate or extent of nitrogen utilization.
95 Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS)
(85 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
8 P03029 (/IMP) P03029 (/IMP) P03029 (/IMP) P03029 (/IMP) P03029 (/IMP) P03029 (/IMP) P03029 (/IMP) P03029 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
7 Q88CY1 (/IDA) Q88CY1 (/IDA) Q88CY1 (/IDA) Q88CY1 (/IDA) Q88CY1 (/IDA) Q88CY1 (/IDA) Q88CY1 (/IDA)
Nitrogen fixation GO:0009399
The process in which nitrogen is taken from its relatively inert molecular form (N2) in the atmosphere and converted into nitrogen compounds useful for other chemical processes, such as ammonia, nitrate and nitrogen dioxide.
1 Q5LRN8 (/ISS)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
57 P0AFB8 (/IDA) P0AFB8 (/IDA) P0AFB8 (/IDA) P0AFB8 (/IDA) P0AFB8 (/IDA) P0AFB8 (/IDA) P0AFB8 (/IDA) P0AFB8 (/IDA) P0AFB8 (/IDA) P0AFB8 (/IDA)
(47 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
7 Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
7 Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI)
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