The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Homeodomain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: Two-component response regulator

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
23 F4IVF9 (/ISS) F4J959 (/ISS) O22210 (/ISS) O22210 (/ISS) O49397 (/ISS) O49397 (/ISS) O49397 (/ISS) P62598 (/ISS) Q6LA43 (/ISS) Q8L9Y3 (/ISS)
(13 more)
Phosphorelay response regulator activity GO:0000156
Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
13 O49397 (/ISS) O49397 (/ISS) O49397 (/ISS) P62598 (/ISS) Q8L9Y3 (/ISS) Q8L9Y3 (/ISS) Q940D0 (/ISS) Q940D0 (/ISS) Q9FXD6 (/ISS) Q9FXD6 (/ISS)
(3 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
13 Q6LA43 (/IPI) Q8L9Y3 (/IPI) Q8L9Y3 (/IPI) Q940D0 (/IPI) Q940D0 (/IPI) Q948L2 (/IPI) Q94LW1 (/IPI) Q9AV93 (/IPI) Q9FFH0 (/IPI) Q9FXD6 (/IPI)
(3 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
9 O49397 (/IDA) O49397 (/IDA) O49397 (/IDA) Q940D0 (/IDA) Q940D0 (/IDA) Q9FXD6 (/IDA) Q9FXD6 (/IDA) Q9LTH4 (/IDA) Q9ZWJ9 (/IDA)
Phosphorelay response regulator activity GO:0000156
Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
2 Q94LW1 (/IDA) Q9AV93 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q8L9Y3 (/IPI) Q8L9Y3 (/IPI)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
2 Q5SML5 (/IDA) Q5SML5 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q7Y0W3 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 F4IVF9 (/IMP)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
1 F4IVF9 (/IDA)

There are 45 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytokinin-activated signaling pathway GO:0009736
A series of molecular signals generated by the binding of a cytokinin to a receptor, and ending with regulation of a downstream cellular process, e.g. transcription.
13 O49397 (/TAS) O49397 (/TAS) O49397 (/TAS) P62598 (/TAS) Q8L9Y3 (/TAS) Q8L9Y3 (/TAS) Q940D0 (/TAS) Q940D0 (/TAS) Q9FXD6 (/TAS) Q9FXD6 (/TAS)
(3 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
10 F4J959 (/TAS) O22210 (/TAS) O22210 (/TAS) Q9C9F6 (/TAS) Q9FF65 (/TAS) Q9LTH4 (/TAS) Q9LZJ8 (/TAS) Q9M9B9 (/TAS) Q9SG82 (/TAS) Q9SG82 (/TAS)
Response to cytokinin GO:0009735
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.
9 O49397 (/IGI) O49397 (/IGI) O49397 (/IGI) P62598 (/IGI) Q940D0 (/IGI) Q940D0 (/IGI) Q9FXD6 (/IGI) Q9FXD6 (/IGI) Q9ZWJ9 (/IGI)
Regulation of root meristem growth GO:0010082
Any process involved in maintaining the size and shape of a root meristem.
9 O49397 (/IMP) O49397 (/IMP) O49397 (/IMP) P62598 (/IMP) Q940D0 (/IMP) Q940D0 (/IMP) Q9FXD6 (/IMP) Q9FXD6 (/IMP) Q9ZWJ9 (/IMP)
Regulation of chlorophyll biosynthetic process GO:0010380
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors.
8 F4IVF9 (/IGI) O49397 (/IGI) O49397 (/IGI) O49397 (/IGI) P62598 (/IGI) Q940D0 (/IGI) Q940D0 (/IGI) Q9FFH0 (/IGI)
Root development GO:0048364
The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo.
7 O49397 (/IMP) O49397 (/IMP) O49397 (/IMP) P62598 (/IMP) Q940D0 (/IMP) Q940D0 (/IMP) Q9ZWJ9 (/IMP)
Cellular response to cytokinin stimulus GO:0071368
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.
7 O49397 (/IMP) O49397 (/IMP) O49397 (/IMP) P62598 (/IMP) Q940D0 (/IMP) Q940D0 (/IMP) Q9ZWJ9 (/IMP)
Regulation of seed growth GO:0080113
Any process that modulates the frequency, rate or extent of growth of the seed of an plant.
7 O49397 (/IMP) O49397 (/IMP) O49397 (/IMP) P62598 (/IMP) Q940D0 (/IMP) Q940D0 (/IMP) Q9ZWJ9 (/IMP)
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
6 O49397 (/IEP) O49397 (/IEP) O49397 (/IEP) P62598 (/IEP) Q940D0 (/IEP) Q940D0 (/IEP)
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
6 O49397 (/IGI) O49397 (/IGI) O49397 (/IGI) P62598 (/IGI) Q940D0 (/IGI) Q940D0 (/IGI)
Cytokinin-activated signaling pathway GO:0009736
A series of molecular signals generated by the binding of a cytokinin to a receptor, and ending with regulation of a downstream cellular process, e.g. transcription.
6 O49397 (/IGI) O49397 (/IGI) O49397 (/IGI) P62598 (/IGI) Q940D0 (/IGI) Q940D0 (/IGI)
Maintenance of shoot apical meristem identity GO:0010492
The process in which an organism retains a population of shoot apical meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate.
6 O49397 (/IGI) O49397 (/IGI) O49397 (/IGI) P62598 (/IGI) Q940D0 (/IGI) Q940D0 (/IGI)
Regulation of anthocyanin metabolic process GO:0031537
Any process that modulates the frequency, rate or extent of chemical reactions and pathways involving anthocyanins.
6 O49397 (/IGI) O49397 (/IGI) O49397 (/IGI) P62598 (/IGI) Q940D0 (/IGI) Q940D0 (/IGI)
Shoot system development GO:0048367
The process whose specific outcome is the progression of the shoot system over time, from its formation to the mature structure.
6 O49397 (/IGI) O49397 (/IGI) O49397 (/IGI) P62598 (/IGI) Q940D0 (/IGI) Q940D0 (/IGI)
Primary root development GO:0080022
The process whose specific outcome is the progression of the primary root over time, from its formation to the mature structure. The primary root develops directly from the embryonic radicle.
6 O49397 (/IGI) O49397 (/IGI) O49397 (/IGI) P62598 (/IGI) Q940D0 (/IGI) Q940D0 (/IGI)
Regulation of cytokinin-activated signaling pathway GO:0080036
Any process that modulates the frequency, rate or extent of cytokinin signaling.
6 O49397 (/IMP) O49397 (/IMP) O49397 (/IMP) P62598 (/IMP) Q940D0 (/IMP) Q940D0 (/IMP)
Cytokinin-activated signaling pathway GO:0009736
A series of molecular signals generated by the binding of a cytokinin to a receptor, and ending with regulation of a downstream cellular process, e.g. transcription.
5 Q5SML5 (/IDA) Q5SML5 (/IDA) Q7XS69 (/IDA) Q7XS69 (/IDA) Q7XS69 (/IDA)
Phosphorelay signal transduction system GO:0000160
A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
4 Q5SML5 (/IDA) Q5SML5 (/IDA) Q94LW1 (/IDA) Q9AV93 (/IDA)
Response to cytokinin GO:0009735
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.
4 Q948L2 (/IEP) Q94LW1 (/IEP) Q9AV93 (/IEP) Q9ZWJ9 (/IEP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
4 F4IVF9 (/IDA) Q5SML5 (/IDA) Q5SML5 (/IDA) Q9FFH0 (/IDA)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
2 F4J959 (/IMP) Q9LTH4 (/IMP)
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
2 O22210 (/IMP) O22210 (/IMP)
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
2 Q940D0 (/IMP) Q940D0 (/IMP)
Chloroplast organization GO:0009658
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chloroplast.
2 F4IVF9 (/IMP) Q9FFH0 (/IMP)
Response to cytokinin GO:0009735
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.
2 Q940D0 (/IMP) Q940D0 (/IMP)
Regulation of abscisic acid-activated signaling pathway GO:0009787
Any process that modulates the frequency, rate or extent of abscisic acid (ABA) signaling.
2 Q9FXD6 (/IMP) Q9FXD6 (/IMP)
Negative regulation of flower development GO:0009910
Any process that stops, prevents, or reduces the frequency, rate or extent of flower development.
2 F4IVF9 (/IGI) Q9FFH0 (/IGI)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 F4IVF9 (/IMP) Q9FFH0 (/IMP)
Positive regulation of short-day photoperiodism, flowering GO:0048576
Any process that activates, maintains or increases short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase.
2 Q7Y0W3 (/IMP) Q7Y0W5 (/IMP)
Axillary shoot meristem initiation GO:0090506
A developmental process that results in the initiation of an axillary shoot meristem. An axillary shoot meristem is a shoot meristem formed in the axil of a leaf.
2 Q940D0 (/IMP) Q940D0 (/IMP)
Negative regulation of leaf senescence GO:1900056
Any process that stops, prevents or reduces the frequency, rate or extent of leaf senescence.
2 Q9FFH0 (/IMP) Q9SIV3 (/IMP)
Regulation of jasmonic acid mediated signaling pathway GO:2000022
Any process that modulates the frequency, rate or extent of jasmonic acid mediated signaling pathway.
2 Q9FXD6 (/IMP) Q9FXD6 (/IMP)
Regulation of salicylic acid mediated signaling pathway GO:2000031
Any process that modulates the frequency, rate or extent of salicylic acid mediated signaling pathway.
2 Q9FXD6 (/IMP) Q9FXD6 (/IMP)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 F4IVF9 (/IEP)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
1 Q9SNB4 (/IEP)
Response to ethylene GO:0009723
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus.
1 Q9ZWJ9 (/IMP)
Embryo development ending in seed dormancy GO:0009793
The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana.
1 Q9LZJ8 (/IMP)
Ethylene-activated signaling pathway GO:0009873
A series of molecular signals generated by the reception of ethylene (ethene, C2H4) by a receptor and ending with modulation of a cellular process, e.g. transcription.
1 Q9ZWJ9 (/IMP)
Regulation of flower development GO:0009909
Any process that modulates the frequency, rate or extent of flower development.
1 Q9LTH4 (/IMP)
Regulation of stomatal movement GO:0010119
Any process that modulates the frequency, rate or extent of stomatal movement.
1 Q9ZWJ9 (/IMP)
Leaf senescence GO:0010150
The process that occurs in a leaf near the end of its active life that is associated with the dismantling of cell components and membranes, loss of functional chloroplasts, and an overall decline in metabolism.
1 Q9ZWJ9 (/IMP)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 F4J959 (/IMP)
Positive regulation of organelle organization GO:0010638
Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.
1 Q5Z5I4 (/IGI)
Positive regulation of circadian rhythm GO:0042753
Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior.
1 Q9SNB4 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q5Z5I4 (/IGI)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
21 O22210 (/IDA) O22210 (/IDA) O49397 (/IDA) O49397 (/IDA) O49397 (/IDA) P62598 (/IDA) Q5SML5 (/IDA) Q5SML5 (/IDA) Q6K8X6 (/IDA) Q6LA43 (/IDA)
(11 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 Q7XS69 (/IDA) Q7XS69 (/IDA) Q7XS69 (/IDA)
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