The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Homeodomain-like
".
FunFam 5: POU domain protein
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 51 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
23 |
A0A0G2K3R5 (/IDA)
A0A0G2K3R5 (/IDA)
A0A0G2KAN4 (/IDA)
O73861 (/IDA)
P09086 (/IDA)
P09086 (/IDA)
P14859 (/IDA)
P14859 (/IDA)
P14859 (/IDA)
P16143 (/IDA)
(13 more) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
17 |
P09086 (/ISA)
P09086 (/ISA)
P14859 (/ISA)
P14859 (/ISA)
P14859 (/ISA)
P20264 (/ISA)
P20264 (/ISA)
P20265 (/ISA)
P20265 (/ISA)
P20265 (/ISA)
(7 more) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
17 |
P09086 (/ISM)
P09086 (/ISM)
P14859 (/ISM)
P14859 (/ISM)
P14859 (/ISM)
P20264 (/ISM)
P20264 (/ISM)
P20265 (/ISM)
P20265 (/ISM)
P20265 (/ISM)
(7 more) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
17 |
P09086 (/NAS)
P09086 (/NAS)
P14859 (/NAS)
P14859 (/NAS)
P14859 (/NAS)
P20264 (/NAS)
P20264 (/NAS)
P20265 (/NAS)
P20265 (/NAS)
P20265 (/NAS)
(7 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
16 |
P14859 (/IPI)
P14859 (/IPI)
P14859 (/IPI)
P20265 (/IPI)
P20265 (/IPI)
P20265 (/IPI)
P20265 (/IPI)
P20265 (/IPI)
P20265 (/IPI)
P20268 (/IPI)
(6 more) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
15 |
P09086 (/TAS)
P09086 (/TAS)
P20264 (/TAS)
P20264 (/TAS)
P20265 (/TAS)
P20265 (/TAS)
P20265 (/TAS)
P20265 (/TAS)
P20265 (/TAS)
P20265 (/TAS)
(5 more) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
12 |
A0A0G2K3R5 (/IDA)
A0A0G2K3R5 (/IDA)
A0A0G2KAN4 (/IDA)
O13007 (/IDA)
P20267 (/IDA)
P31360 (/IDA)
P56222 (/IDA)
P62516 (/IDA)
P62516 (/IDA)
P62516 (/IDA)
(2 more) |
|
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
11 |
P16241 (/IDA)
P16241 (/IDA)
P31360 (/IDA)
P31368 (/IDA)
P31368 (/IDA)
P31369 (/IDA)
P31369 (/IDA)
Q00196 (/IDA)
Q9UKI9 (/IDA)
Q9VK71 (/IDA)
(1 more) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
10 | P14859 (/IDA) P14859 (/IDA) P14859 (/IDA) P21952 (/IDA) P25425 (/IDA) P31360 (/IDA) P31361 (/IDA) P31362 (/IDA) P56222 (/IDA) Q00196 (/IDA) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
7 | P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P20268 (/ISS) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
6 | P31360 (/ISO) P31361 (/ISO) P62515 (/ISO) P62515 (/ISO) P62515 (/ISO) Q00196 (/ISO) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
6 | P20265 (/IPI) P20265 (/IPI) P20265 (/IPI) P20265 (/IPI) P20265 (/IPI) P20265 (/IPI) |
|
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
|
5 | P16241 (/IDA) P16241 (/IDA) P62515 (/IDA) P62515 (/IDA) P62515 (/IDA) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
5 | P21952 (/ISO) P25425 (/ISO) P31360 (/ISO) P31362 (/ISO) Q00196 (/ISO) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
5 | P20264 (/ISS) P20264 (/ISS) Q28BL7 (/ISS) Q29087 (/ISS) Q63262 (/ISS) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
4 | P14859 (/IMP) P14859 (/IMP) P14859 (/IMP) Q9UKI9 (/IMP) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
4 | P31369 (/IMP) P31369 (/IMP) Q9VK71 (/IMP) Q9VK71 (/IMP) |
|
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
|
3 | P31368 (/IDA) P31368 (/IDA) P31503 (/IDA) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
3 | P20267 (/IDA) P31360 (/IDA) Q00196 (/IDA) |
|
RNA polymerase II core promoter sequence-specific DNA binding GO:0000979
Interacting selectively and non-covalently with a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene.
|
3 | P14859 (/IMP) P14859 (/IMP) P14859 (/IMP) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
3 | P14859 (/IMP) P14859 (/IMP) P14859 (/IMP) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
3 | P21952 (/ISO) P25425 (/ISO) P31361 (/ISO) |
|
AT DNA binding GO:0003680
Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA).
|
3 | P62516 (/IDA) P62516 (/IDA) P62516 (/IDA) |
|
AT DNA binding GO:0003680
Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA).
|
3 | P62515 (/ISO) P62515 (/ISO) P62515 (/ISO) |
|
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
3 | P62516 (/IDA) P62516 (/IDA) P62516 (/IDA) |
|
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
3 | P62515 (/ISO) P62515 (/ISO) P62515 (/ISO) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
3 | P21952 (/IDA) P31360 (/IDA) P56222 (/IDA) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
2 | P25425 (/ISO) P31362 (/ISO) |
|
RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980
Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
|
2 | P16241 (/IDA) P16241 (/IDA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | P20267 (/IDA) Q63262 (/IDA) |
|
Enhancer sequence-specific DNA binding GO:0001158
Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter.
|
2 | O13007 (/IDA) O57602 (/IDA) |
|
Transcription coactivator binding GO:0001223
Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
|
2 | O13007 (/IMP) O57602 (/IMP) |
|
Transcription coactivator binding GO:0001223
Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
|
2 | F1NSK6 (/IPI) P15143 (/IPI) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
2 | P25425 (/ISO) P31360 (/ISO) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
2 | P25425 (/IDA) P31503 (/IDA) |
|
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
|
1 | P25425 (/ISO) |
|
RNA polymerase II core promoter sequence-specific DNA binding GO:0000979
Interacting selectively and non-covalently with a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene.
|
1 | P25425 (/ISO) |
|
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
1 | P20267 (/IDA) |
|
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
1 | Q9UKI9 (/IMP) |
|
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
1 | P31362 (/ISO) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
1 | P25425 (/ISO) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
1 | P31360 (/ISO) |
|
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
1 | P31503 (/IPI) |
|
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
1 | P25425 (/ISO) |
|
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
1 | Q00196 (/IPI) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | P31360 (/ISO) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
1 | Q29076 (/IC) |
|
Protein dimerization activity GO:0046983
The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
|
1 | P31362 (/IDA) |
|
HMG box domain binding GO:0071837
Interacting selectively and non-covalently with an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin.
|
1 | P56222 (/IDA) |
|
HMG box domain binding GO:0071837
Interacting selectively and non-covalently with an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin.
|
1 | P31361 (/IPI) |
|
HMG box domain binding GO:0071837
Interacting selectively and non-covalently with an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin.
|
1 | P31360 (/ISO) |
There are 145 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
12 |
P14859 (/IDA)
P14859 (/IDA)
P14859 (/IDA)
P16241 (/IDA)
P16241 (/IDA)
P20267 (/IDA)
P25425 (/IDA)
P31360 (/IDA)
P31362 (/IDA)
Q00196 (/IDA)
(2 more) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
9 | P16143 (/ISS) P20264 (/ISS) P20264 (/ISS) P20267 (/ISS) Q03052 (/ISS) Q03052 (/ISS) Q28BL7 (/ISS) Q29087 (/ISS) Q63262 (/ISS) |
|
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
|
7 | P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P56222 (/ISS) |
|
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
|
7 | P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P56222 (/ISS) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
7 | P14859 (/IGI) P14859 (/IGI) P14859 (/IGI) P20267 (/IGI) P25425 (/IGI) P31360 (/IGI) P31361 (/IGI) |
|
Neuron fate commitment GO:0048663
The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron.
|
7 | P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P56222 (/ISS) |
|
Neuron fate specification GO:0048665
The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.
|
7 | P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P56222 (/ISS) |
|
Neuron development GO:0048666
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
|
7 | P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P56222 (/ISS) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
6 | A0A0G2K3R5 (/IDA) A0A0G2K3R5 (/IDA) A0A0G2KAN4 (/IDA) P20267 (/IDA) P56222 (/IDA) Q00196 (/IDA) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
6 | P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) P20265 (/ISS) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
6 | P20265 (/IDA) P20265 (/IDA) P20265 (/IDA) P20265 (/IDA) P20265 (/IDA) P20265 (/IDA) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
6 | P20264 (/ISS) P20264 (/ISS) P20267 (/ISS) Q03052 (/ISS) Q03052 (/ISS) Q29087 (/ISS) |
|
Cochlea morphogenesis GO:0090103
The process in which the cochlea is generated and organized.
|
6 | P49335 (/ISS) P62516 (/ISS) P62516 (/ISS) P62516 (/ISS) Q812B1 (/ISS) Q812B1 (/ISS) |
|
Negative regulation of mesenchymal cell apoptotic process GO:2001054
Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process.
|
6 | P49335 (/ISS) P62516 (/ISS) P62516 (/ISS) P62516 (/ISS) Q812B1 (/ISS) Q812B1 (/ISS) |
|
SnRNA transcription by RNA polymerase II GO:0042795
The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter.
|
5 | P09086 (/TAS) P09086 (/TAS) P14859 (/TAS) P14859 (/TAS) P14859 (/TAS) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
5 | P14859 (/IDA) P14859 (/IDA) P14859 (/IDA) P20267 (/IDA) P31361 (/IDA) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
5 | P14859 (/IMP) P14859 (/IMP) P14859 (/IMP) P16241 (/IMP) P16241 (/IMP) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
4 | P31369 (/IMP) P31369 (/IMP) Q9VK71 (/IMP) Q9VK71 (/IMP) |
|
Ectoderm development GO:0007398
The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.
|
4 | P31369 (/IMP) P31369 (/IMP) Q9VK71 (/IMP) Q9VK71 (/IMP) |
|
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
|
4 | P31369 (/IMP) P31369 (/IMP) Q9VK71 (/IMP) Q9VK71 (/IMP) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
4 | P20264 (/ISS) P20264 (/ISS) Q29087 (/ISS) Q63262 (/ISS) |
|
Neuroblast development GO:0014019
The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron.
|
4 | P31369 (/IMP) P31369 (/IMP) Q9VK71 (/IMP) Q9VK71 (/IMP) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
4 | P20264 (/ISS) P20264 (/ISS) Q29087 (/ISS) Q63262 (/ISS) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
4 | P20264 (/ISS) P20264 (/ISS) Q29087 (/ISS) Q63262 (/ISS) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
4 | P21952 (/ISO) P25425 (/ISO) P31361 (/ISO) P31362 (/ISO) |
|
Generation of neurons GO:0048699
The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons.
|
4 | P31369 (/IMP) P31369 (/IMP) Q9VK71 (/IMP) Q9VK71 (/IMP) |
|
Metanephric ascending thin limb development GO:0072218
The process whose specific outcome is the progression of a metanephric ascending thin limb over time, from its formation to the mature structure. The metanephric ascending thin limb is a segment of a nephron tubule in the metanephros lying in the inner medulla that is permeable to ions but not to water and has a simple epithelium; active transepithelial solute transport is absent.
|
4 | P20264 (/ISS) P20264 (/ISS) Q29087 (/ISS) Q63262 (/ISS) |
|
Metanephric macula densa development GO:0072227
The process whose specific outcome is the progression of the metanephric macula densa over time, from its formation to the mature structure. The metanephric macula densa is an area of specialized cells in the distal tubule of the metanephros that makes contact with the vascular pole of the glomerulus.
|
4 | P20264 (/ISS) P20264 (/ISS) Q29087 (/ISS) Q63262 (/ISS) |
|
Metanephric thick ascending limb development GO:0072233
The process whose specific outcome is the progression of the metanephric thick ascending limb over time, from its formation to the mature structure. The metanephric thick ascending limb is the last part of the metanephric loop of Henle. Its thick, mitochondria-rich epithelium characterizes the outer medulla, and is responsible for very avid active salt transport. At the macula densa, the thick ascending limb connects to the distal convoluted tubule.
|
4 | P20264 (/ISS) P20264 (/ISS) Q29087 (/ISS) Q63262 (/ISS) |
|
Metanephric loop of Henle development GO:0072236
The process whose specific outcome is the progression of the metanephric loop of Henle over time, from its formation to the mature structure. The metanephric loop of Henle is a metanephric nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule in the metanephros.
|
4 | P20264 (/ISS) P20264 (/ISS) Q29087 (/ISS) Q63262 (/ISS) |
|
Metanephric DCT cell differentiation GO:0072240
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the distal convoluted tubule cells of the metanephros as it progresses from its formation to the mature state.
|
4 | P20264 (/ISS) P20264 (/ISS) Q29087 (/ISS) Q63262 (/ISS) |
|
Regulation of neural precursor cell proliferation GO:2000177
Any process that modulates the frequency, rate or extent of neural precursor cell proliferation.
|
4 | P31368 (/IGI) P31368 (/IGI) Q9VK71 (/IGI) Q9VK71 (/IGI) |
|
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
|
3 | P62516 (/IDA) P62516 (/IDA) P62516 (/IDA) |
|
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
|
3 | P62515 (/ISO) P62515 (/ISO) P62515 (/ISO) |
|
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
|
3 | P62515 (/IMP) P62515 (/IMP) P62515 (/IMP) |
|
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
3 | P14859 (/TAS) P14859 (/TAS) P14859 (/TAS) |
|
Forebrain neuron differentiation GO:0021879
The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain.
|
3 | P62515 (/IMP) P62515 (/IMP) P62515 (/IMP) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | O13007 (/IDA) P21952 (/IDA) Q00196 (/IDA) |
|
Inner ear development GO:0048839
The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure.
|
3 | P62515 (/IMP) P62515 (/IMP) P62515 (/IMP) |
|
Cochlea morphogenesis GO:0090103
The process in which the cochlea is generated and organized.
|
3 | P62515 (/IGI) P62515 (/IGI) P62515 (/IGI) |
|
Negative regulation of mesenchymal cell apoptotic process GO:2001054
Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process.
|
3 | P62515 (/IGI) P62515 (/IGI) P62515 (/IGI) |
|
Positive regulation of antimicrobial peptide biosynthetic process GO:0002807
Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis.
|
2 | P16241 (/IDA) P16241 (/IDA) |
|
Negative regulation of antibacterial peptide biosynthetic process GO:0002809
Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide biosynthesis.
|
2 | P31368 (/IMP) P31368 (/IMP) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P31360 (/ISO) Q00196 (/ISO) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P20267 (/TAS) P20268 (/TAS) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | P31360 (/IDA) P42571 (/IDA) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | P31368 (/IMP) P31368 (/IMP) |
|
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
|
2 | P09086 (/TAS) P09086 (/TAS) |
|
Humoral immune response GO:0006959
An immune response mediated through a body fluid.
|
2 | P09086 (/TAS) P09086 (/TAS) |
|
Pattern specification process GO:0007389
Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.
|
2 | P31368 (/NAS) P31368 (/NAS) |
|
Ganglion mother cell fate determination GO:0007402
The cell fate determination process in which a cell becomes capable of differentiating autonomously into a ganglion mother cell regardless of its environment; upon determination, the cell fate cannot be reversed.
|
2 | P31368 (/TAS) P31368 (/TAS) |
|
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
|
2 | P20264 (/TAS) P20264 (/TAS) |
|
Ventral cord development GO:0007419
The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms.
|
2 | P31368 (/NAS) P31368 (/NAS) |
|
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
|
2 | P16241 (/IMP) P16241 (/IMP) |
|
Peripheral nervous system development GO:0007422
The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
|
2 | P16241 (/IMP) P16241 (/IMP) |
|
Peripheral nervous system development GO:0007422
The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
|
2 | P16241 (/TAS) P16241 (/TAS) |
|
Excretion GO:0007588
The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.
|
2 | P20268 (/IMP) P31361 (/IMP) |
|
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
|
2 | P16241 (/IMP) P16241 (/IMP) |
|
Axon ensheathment GO:0008366
Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal.
|
2 | Q03052 (/TAS) Q03052 (/TAS) |
|
Epidermis development GO:0008544
The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
|
2 | P21952 (/IGI) P31362 (/IGI) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | O13007 (/IDA) P21952 (/IDA) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | P31360 (/IMP) P31503 (/IMP) |
|
Cerebral cortex radially oriented cell migration GO:0021799
The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain.
|
2 | P31360 (/IGI) P31361 (/IGI) |
|
Forebrain ventricular zone progenitor cell division GO:0021869
The mitotic division of a basal progenitor giving rise to two neurons.
|
2 | P31360 (/IGI) P31361 (/IGI) |
|
Myelination in peripheral nervous system GO:0022011
The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
|
2 | P21952 (/IGI) P31360 (/IGI) |
|
Keratinocyte differentiation GO:0030216
The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte.
|
2 | P21952 (/IGI) P31362 (/IGI) |
|
Brain segmentation GO:0035284
Division of the brain into a series of semi-repetitive parts or segments.
|
2 | P16241 (/IMP) P16241 (/IMP) |
|
Limb joint morphogenesis GO:0036022
The process in which the anatomical structures of a limb joint are generated and organized. A limb joint is a flexible region that separates the rigid sections of a limb to allow movement in a controlled manner.
|
2 | P31368 (/IMP) P31368 (/IMP) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P31361 (/IMP) Q63262 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | P16143 (/ISS) Q28BL7 (/ISS) |
|
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
|
2 | P31368 (/IMP) P31368 (/IMP) |
|
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
|
2 | P16241 (/TAS) P16241 (/TAS) |
|
Regulation of dendrite morphogenesis GO:0048814
Any process that modulates the frequency, rate or extent of dendrite morphogenesis.
|
2 | P16241 (/IMP) P16241 (/IMP) |
|
Regulation of neurogenesis GO:0050767
Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.
|
2 | P31368 (/IMP) P31368 (/IMP) |
|
Heterochromatin organization involved in chromatin silencing GO:0070868
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing.
|
2 | P31368 (/IMP) P31368 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | P20267 (/IDA) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q63262 (/IGI) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | P31361 (/ISO) |
|
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
|
1 | P31361 (/IMP) |
|
Endothelial cell development GO:0001885
The progression of an endothelial cell over time, from its formation to the mature structure.
|
1 | P79746 (/IMP) |
|
Mature B cell differentiation GO:0002335
The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen.
|
1 | Q00196 (/IMP) |
|
Immunoglobulin secretion involved in immune response GO:0002380
The regulated release of immunoglobulins from a B cell or plasma cell contributing to an immune response.
|
1 | Q00196 (/IMP) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | P31362 (/ISO) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q9UKI9 (/TAS) |
|
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | P16143 (/IMP) |
|
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q28BL7 (/ISS) |
|
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
|
1 | P31360 (/IDA) |
|
Peripheral nervous system development GO:0007422
The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
|
1 | O73861 (/IEP) |
|
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
|
1 | P49335 (/TAS) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | P31361 (/IMP) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | P31360 (/ISO) |
|
Epidermis development GO:0008544
The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
|
1 | P42571 (/IDA) |
|
Epidermis development GO:0008544
The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
|
1 | P31360 (/IMP) |
|
Epidermis development GO:0008544
The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
|
1 | P31362 (/ISO) |
|
Epidermis development GO:0008544
The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
|
1 | Q9UKI9 (/TAS) |
|
Glial cell differentiation GO:0010001
The process in which a relatively unspecialized cell acquires the specialized features of a glial cell.
|
1 | P20267 (/IDA) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | Q63262 (/IMP) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | P31361 (/ISO) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | O57602 (/IDA) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | P25425 (/ISO) |
|
Astrocyte development GO:0014002
The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.
|
1 | P31360 (/IMP) |
|
Neural crest cell differentiation GO:0014033
The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell.
|
1 | Q2VUE0 (/IEP) |
|
Schwann cell development GO:0014044
The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function.
|
1 | P31360 (/IGI) |
|
Schwann cell development GO:0014044
The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function.
|
1 | P21952 (/IMP) |
|
Central nervous system formation GO:0021556
The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
|
1 | Q2VUE0 (/IEP) |
|
Hypothalamus cell differentiation GO:0021979
The differentiation of cells that will contribute to the structure and function of the hypothalamus.
|
1 | P31360 (/IMP) |
|
Neurohypophysis development GO:0021985
The progression of the neurohypophysis over time from its initial formation until its mature state. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation.
|
1 | P31360 (/IMP) |
|
Water homeostasis GO:0030104
Any process involved in the maintenance of an internal steady state of water within an organism or cell.
|
1 | P20268 (/IMP) |
|
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
|
1 | P20268 (/IMP) |
|
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
|
1 | P31360 (/IDA) |
|
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
|
1 | P21952 (/IMP) |
|
Olfactory placode formation GO:0030910
The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity.
|
1 | P25425 (/IGI) |
|
Pronephric field specification GO:0039003
The process in which regions of the embryo are delineated into the area in which the pronephric kidney will develop.
|
1 | Q2VUE0 (/IEP) |
|
Positive regulation of multicellular organism growth GO:0040018
Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
|
1 | P31360 (/IMP) |
|
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
|
1 | P31362 (/IMP) |
|
Myelination GO:0042552
The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
|
1 | P21952 (/IMP) |
|
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
|
1 | P16143 (/IMP) |
|
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
|
1 | Q28BL7 (/ISS) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | P31361 (/IMP) |
|
Negative regulation by host of viral transcription GO:0043922
Any process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription.
|
1 | Q9UKI9 (/IDA) |
|
Negative regulation by host of viral transcription GO:0043922
Any process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription.
|
1 | P31362 (/ISO) |
|
Regulation of cell differentiation GO:0045595
Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.
|
1 | P31360 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q29076 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P25425 (/ISO) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q63262 (/IGI) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P31361 (/ISO) |
|
Immunoglobulin secretion GO:0048305
The regulated release of immunoglobulins from a B cell or plasma cell, whose mechanism includes the use of alternate polyadenylylation signals to favor the biosynthesis of secreted forms of immunoglobulin over membrane-bound immunoglobulin.
|
1 | Q00196 (/IMP) |
|
Cell maturation GO:0048469
A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.
|
1 | Q00196 (/IMP) |
|
Neuron fate commitment GO:0048663
The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron.
|
1 | P31360 (/IDA) |
|
Neuron fate specification GO:0048665
The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.
|
1 | P31360 (/IDA) |
|
Neuron development GO:0048666
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
|
1 | P31360 (/IDA) |
|
Chemical homeostasis GO:0048878
Any biological process involved in the maintenance of an internal steady state of a chemical.
|
1 | P31361 (/IMP) |
|
Regulation of axonogenesis GO:0050770
Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
|
1 | P31360 (/IMP) |
|
Radial glial cell differentiation GO:0060019
The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the brain. Differentiation includes the processes involved in commitment of a cell to a specific fate.
|
1 | P16143 (/IMP) |
|
Radial glial cell differentiation GO:0060019
The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the brain. Differentiation includes the processes involved in commitment of a cell to a specific fate.
|
1 | Q28BL7 (/ISS) |
|
Lens induction in camera-type eye GO:0060235
Signaling at short range between the head ectoderm and the optic vesicle that results in the head ectoderm forming a lens.
|
1 | P25425 (/IGI) |
|
Transdifferentiation GO:0060290
The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate.
|
1 | P20268 (/IMP) |
|
Mesonephric mesenchyme development GO:0061219
The biological process whose specific outcome is the progression of a mesonephric mesenchyme from an initial condition to its mature state. This process begins with the formation of mesonephric mesenchyme and ends with the mature structure. Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros.
|
1 | Q2VUE0 (/IEP) |
|
Cellular response to organic substance GO:0071310
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
|
1 | P31360 (/IDA) |
|
Metanephric ascending thin limb development GO:0072218
The process whose specific outcome is the progression of a metanephric ascending thin limb over time, from its formation to the mature structure. The metanephric ascending thin limb is a segment of a nephron tubule in the metanephros lying in the inner medulla that is permeable to ions but not to water and has a simple epithelium; active transepithelial solute transport is absent.
|
1 | P31361 (/IMP) |
|
Metanephric macula densa development GO:0072227
The process whose specific outcome is the progression of the metanephric macula densa over time, from its formation to the mature structure. The metanephric macula densa is an area of specialized cells in the distal tubule of the metanephros that makes contact with the vascular pole of the glomerulus.
|
1 | P31361 (/IMP) |
|
Metanephric thick ascending limb development GO:0072233
The process whose specific outcome is the progression of the metanephric thick ascending limb over time, from its formation to the mature structure. The metanephric thick ascending limb is the last part of the metanephric loop of Henle. Its thick, mitochondria-rich epithelium characterizes the outer medulla, and is responsible for very avid active salt transport. At the macula densa, the thick ascending limb connects to the distal convoluted tubule.
|
1 | P31361 (/IMP) |
|
Metanephric loop of Henle development GO:0072236
The process whose specific outcome is the progression of the metanephric loop of Henle over time, from its formation to the mature structure. The metanephric loop of Henle is a metanephric nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule in the metanephros.
|
1 | P31361 (/IMP) |
|
Metanephric DCT cell differentiation GO:0072240
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the distal convoluted tubule cells of the metanephros as it progresses from its formation to the mature state.
|
1 | P31361 (/IMP) |
|
Liver regeneration GO:0097421
The regrowth of lost or destroyed liver.
|
1 | P31503 (/IEP) |
There are 20 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
36 |
A0A0G2K3R5 (/IDA)
A0A0G2K3R5 (/IDA)
A0A0G2KAN4 (/IDA)
O13007 (/IDA)
O57602 (/IDA)
P09086 (/IDA)
P09086 (/IDA)
P14859 (/IDA)
P14859 (/IDA)
P14859 (/IDA)
(26 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
24 |
A0A024R8Y2 (/IDA)
A0A024R8Y2 (/IDA)
A0A024R8Y2 (/IDA)
A0A0A0MT46 (/IDA)
A0A0A0MT46 (/IDA)
A0A0C4DG88 (/IDA)
A0A0C4DG88 (/IDA)
B5ME60 (/IDA)
B5ME60 (/IDA)
H0YKT2 (/IDA)
(14 more) |
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
22 |
A0A024R8Y2 (/IDA)
A0A024R8Y2 (/IDA)
A0A024R8Y2 (/IDA)
A0A0A0MT46 (/IDA)
A0A0A0MT46 (/IDA)
A0A0C4DG88 (/IDA)
A0A0C4DG88 (/IDA)
B5ME60 (/IDA)
B5ME60 (/IDA)
H0YKT2 (/IDA)
(12 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
8 | P25425 (/ISO) P31360 (/ISO) P31361 (/ISO) P31362 (/ISO) P62515 (/ISO) P62515 (/ISO) P62515 (/ISO) Q00196 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
8 | P20264 (/ISS) P20264 (/ISS) P20267 (/ISS) P31361 (/ISS) Q03052 (/ISS) Q03052 (/ISS) Q28BL7 (/ISS) Q29087 (/ISS) |
|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
8 | A0A024R8Y2 (/IDA) A0A024R8Y2 (/IDA) A0A024R8Y2 (/IDA) A0A0C4DG88 (/IDA) A0A0C4DG88 (/IDA) P14859 (/IDA) P14859 (/IDA) P14859 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
5 | P09086 (/TAS) P09086 (/TAS) P14859 (/TAS) P14859 (/TAS) P14859 (/TAS) |
|
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
4 | P21952 (/IDA) P25425 (/IDA) P31360 (/IDA) P31362 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | P31369 (/IC) P31369 (/IC) Q29076 (/IC) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | Q63262 (/IMP) Q9VK71 (/IMP) Q9VK71 (/IMP) |
|
RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
|
3 | P14859 (/IMP) P14859 (/IMP) P14859 (/IMP) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | P25425 (/ISO) Q00196 (/ISO) |
|
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
2 | P16143 (/ISS) Q28BL7 (/ISS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | P16143 (/IDA) P20268 (/IDA) |
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
2 | P25425 (/ISO) Q00196 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P20267 (/TAS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q28BL7 (/ISS) |
|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
1 | P25425 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P20268 (/IDA) |
|
RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
|
1 | P25425 (/ISO) |
