The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Homeodomain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 338: Homeobox protein Nkx-3.1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Nuclear receptor activity GO:0004879
Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Estrogen receptor activity GO:0030284
Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Estrogen receptor binding GO:0030331
Interacting selectively and non-covalently with an estrogen receptor.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 Q9W7E8 (/ISS) Q9W7E8 (/ISS)

There are 29 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
6 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS) Q9W7E8 (/ISS) Q9W7E8 (/ISS)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Salivary gland development GO:0007431
The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Positive regulation of cell death GO:0010942
Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Androgen receptor signaling pathway GO:0030521
Any series of molecular signals generated as a consequence of an androgen binding to its receptor.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Response to testosterone GO:0033574
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280
Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Protein kinase B signaling GO:0043491
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Negative regulation of insulin-like growth factor receptor signaling pathway GO:0043569
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Positive regulation of mitotic cell cycle GO:0045931
Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Branching morphogenesis of an epithelial tube GO:0048754
The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Negative regulation of epithelial cell proliferation GO:0050680
Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Positive regulation of cell division GO:0051781
Any process that activates or increases the frequency, rate or extent of cell division.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Branching involved in prostate gland morphogenesis GO:0060442
The process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664
The multiplication or reproduction of epithelial cells of the submandibular salivary gland, resulting in the expansion of a cell population and the shaping of the gland.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Negative regulation of epithelial cell proliferation involved in prostate gland development GO:0060770
Any process that decreases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Cellular response to steroid hormone stimulus GO:0071383
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Negative regulation of estrogen receptor binding GO:0071899
Any process that stops, prevents, or reduces the frequency, rate or extent of estrogen receptor binding, interacting selectively with an estrogen receptor.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Positive regulation of androgen secretion GO:2000836
Any process that activates or increases the frequency, rate or extent of androgen secretion.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Positive regulation of response to DNA damage stimulus GO:2001022
Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Positive regulation of intrinsic apoptotic signaling pathway GO:2001244
Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
2 Q9W7E8 (/IMP) Q9W7E8 (/IMP)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 D2H028 (/ISS) F1PRX2 (/ISS) F6Y020 (/ISS) Q497B7 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q9W7E8 (/NAS) Q9W7E8 (/NAS)
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