The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Homeodomain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 260: Fis family transcriptional regulator

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
26 G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP)
(16 more)
Proximal promoter sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter.
22 G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA)
(12 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
22 G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP)
(12 more)
Cyclic-di-GMP binding GO:0035438
Interacting selectively and non-covalently with cyclic-di-GMP, cyclic dimeric guanosine monophosphate.
22 G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA)
(12 more)
Cyclic-di-GMP binding GO:0035438
Interacting selectively and non-covalently with cyclic-di-GMP, cyclic dimeric guanosine monophosphate.
22 G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI)
(12 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
20 Q884Y2 (/ISS) Q884Y2 (/ISS) Q884Y2 (/ISS) Q884Y2 (/ISS) Q884Y2 (/ISS) Q884Y2 (/ISS) Q884Y2 (/ISS) Q884Y2 (/ISS) Q884Y2 (/ISS) Q884Y2 (/ISS)
(10 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
15 G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP)
(5 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
11 G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA)
(1 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
11 G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI)
(1 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
11 G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA)
(1 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
11 G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI)
(1 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
11 G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI)
(1 more)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
22 G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA)
(12 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
22 G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA)
(12 more)
Positive regulation of cell-substrate adhesion GO:0010811
Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
22 G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP)
(12 more)
Negative regulation of extracellular matrix assembly GO:1901202
Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly.
22 G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP)
(12 more)
Regulation of bacterial-type flagellum-dependent cell motility GO:1902021
Any process that modulates the frequency, rate or extent of bacterial-type flagellum-dependent cell motility.
22 G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP)
(12 more)
Positive regulation of cilium-dependent cell motility GO:2000155
Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility.
22 G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP)
(12 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
20 Q884Y2 (/ISS) Q884Y2 (/ISS) Q884Y2 (/ISS) Q884Y2 (/ISS) Q884Y2 (/ISS) Q884Y2 (/ISS) Q884Y2 (/ISS) Q884Y2 (/ISS) Q884Y2 (/ISS) Q884Y2 (/ISS)
(10 more)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
15 G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP) G3XCV0 (/IMP)
(5 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
11 G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA) G3XCV0 (/IDA)
(1 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
11 G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI) G3XCV0 (/IPI)
(1 more)
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