The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Homeodomain-like
".
FunFam 26: Nuclear receptor corepressor 2 isoform 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 47 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
11 |
A0A024RBS3 (/IPI)
A0A0G2JU91 (/IPI)
D3ZXN9 (/IPI)
M9PGZ8 (/IPI)
O75376 (/IPI)
O75376 (/IPI)
Q60974 (/IPI)
Q9U4I2 (/IPI)
Q9WU42 (/IPI)
Q9Y618 (/IPI)
(1 more) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
6 | A0A0G2JU91 (/IDA) D3ZXN9 (/IDA) M9PGZ8 (/IDA) Q9U4I2 (/IDA) Q9VYK0 (/IDA) Q9WU42 (/IDA) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
5 | O75376 (/IDA) O75376 (/IDA) Q9WU42 (/IDA) Q9Y618 (/IDA) Q9Y618 (/IDA) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
5 | O75376 (/IMP) O75376 (/IMP) Q9WU42 (/IMP) Q9Y618 (/IMP) Q9Y618 (/IMP) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
5 | M9PGZ8 (/TAS) O75376 (/TAS) O75376 (/TAS) Q9U4I2 (/TAS) Q9VYK0 (/TAS) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
4 | O75376 (/ISA) O75376 (/ISA) Q9Y618 (/ISA) Q9Y618 (/ISA) |
|
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
|
4 | O75376 (/IPI) O75376 (/IPI) Q9Y618 (/IPI) Q9Y618 (/IPI) |
|
RNA polymerase II regulatory region DNA binding GO:0001012
Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase II. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
2 | A0A0G2JU91 (/IDA) D3ZXN9 (/IDA) |
|
RNA polymerase II regulatory region DNA binding GO:0001012
Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase II. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
2 | Q60974 (/ISO) Q9WU42 (/ISO) |
|
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
|
2 | O75376 (/IPI) O75376 (/IPI) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
2 | Q60974 (/IDA) Q9WU42 (/IDA) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
2 | Q60974 (/ISO) Q9WU42 (/ISO) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
2 | Q60974 (/IGI) Q9WU42 (/IGI) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
2 | Q60974 (/ISO) Q9WU42 (/ISO) |
|
Notch binding GO:0005112
Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor.
|
2 | Q9Y618 (/IPI) Q9Y618 (/IPI) |
|
Nuclear receptor binding GO:0016922
Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein.
|
2 | A0A0G2JU91 (/IPI) D3ZXN9 (/IPI) |
|
Nuclear hormone receptor binding GO:0035257
Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.
|
2 | O75376 (/IPI) O75376 (/IPI) |
|
Glucocorticoid receptor binding GO:0035259
Interacting selectively and non-covalently with a glucocorticoid receptor.
|
2 | A0A0G2JU91 (/IPI) D3ZXN9 (/IPI) |
|
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
|
2 | Q60974 (/ISO) Q9WU42 (/ISO) |
|
Retinoic acid receptor binding GO:0042974
Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily.
|
2 | A0A0G2JU91 (/IPI) D3ZXN9 (/IPI) |
|
Retinoic acid receptor binding GO:0042974
Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily.
|
2 | Q60974 (/ISO) Q9WU42 (/ISO) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
2 | Q60974 (/IDA) Q9WU42 (/IDA) |
|
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
2 | O75376 (/ISS) O75376 (/ISS) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
2 | A0A0G2JU91 (/IPI) D3ZXN9 (/IPI) |
|
Retinoid X receptor binding GO:0046965
Interacting selectively and non-covalently with a retinoid X receptor.
|
2 | A0A0G2JU91 (/IPI) D3ZXN9 (/IPI) |
|
Retinoid X receptor binding GO:0046965
Interacting selectively and non-covalently with a retinoid X receptor.
|
2 | Q60974 (/ISO) Q9WU42 (/ISO) |
|
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
2 | Q9Y618 (/IPI) Q9Y618 (/IPI) |
|
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
|
1 | Q60974 (/ISO) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | Q10369 (/ISM) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
1 | Q60974 (/IDA) |
|
Notch binding GO:0005112
Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor.
|
1 | Q9WU42 (/ISO) |
|
Nuclear receptor binding GO:0016922
Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein.
|
1 | Q9WU42 (/ISO) |
|
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
1 | Q60974 (/IPI) |
|
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
1 | Q60974 (/ISO) |
|
Estrogen receptor binding GO:0030331
Interacting selectively and non-covalently with an estrogen receptor.
|
1 | Q60974 (/ISO) |
|
Histone deacetylase regulator activity GO:0035033
Modulates the activity of histone deacetylase.
|
1 | Q60974 (/IDA) |
|
Histone deacetylase regulator activity GO:0035033
Modulates the activity of histone deacetylase.
|
1 | Q60974 (/IMP) |
|
Nuclear hormone receptor binding GO:0035257
Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.
|
1 | Q60974 (/ISO) |
|
Glucocorticoid receptor binding GO:0035259
Interacting selectively and non-covalently with a glucocorticoid receptor.
|
1 | Q9WU42 (/ISO) |
|
Retinoic acid receptor binding GO:0042974
Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily.
|
1 | Q60974 (/IDA) |
|
Peroxisome proliferator activated receptor binding GO:0042975
Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma.
|
1 | Q60974 (/ISO) |
|
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
1 | Q60974 (/IDA) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
1 | Q9WU42 (/ISO) |
|
Retinoid X receptor binding GO:0046965
Interacting selectively and non-covalently with a retinoid X receptor.
|
1 | Q60974 (/IDA) |
|
Thyroid hormone receptor binding GO:0046966
Interacting selectively and non-covalently with a thyroid hormone receptor.
|
1 | Q60974 (/IDA) |
|
Thyroid hormone receptor binding GO:0046966
Interacting selectively and non-covalently with a thyroid hormone receptor.
|
1 | Q60974 (/IPI) |
|
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | Q9WU42 (/ISO) |
There are 73 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
7 | M9PGZ8 (/IMP) O75376 (/IMP) O75376 (/IMP) Q60974 (/IMP) Q9WU42 (/IMP) Q9Y618 (/IMP) Q9Y618 (/IMP) |
|
Neutrophil differentiation GO:0030223
The process in which a myeloid precursor cell acquires the specialized features of a neutrophil.
|
6 | A3QK40 (/IMP) A8B6H7 (/IMP) E7FF48 (/IMP) F1R8E1 (/IMP) F1R8Z8 (/IMP) G3GBZ0 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
6 | O75376 (/IMP) O75376 (/IMP) Q60974 (/IMP) Q9WU42 (/IMP) Q9Y618 (/IMP) Q9Y618 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
4 | O75376 (/TAS) O75376 (/TAS) Q9Y618 (/TAS) Q9Y618 (/TAS) |
|
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
|
4 | O75376 (/TAS) O75376 (/TAS) Q9Y618 (/TAS) Q9Y618 (/TAS) |
|
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
|
4 | E7FF48 (/IMP) F1R8E1 (/IMP) F1R8Z8 (/IMP) G3GBZ0 (/IMP) |
|
Myeloid cell differentiation GO:0030099
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.
|
4 | E7FF48 (/IMP) F1R8E1 (/IMP) F1R8Z8 (/IMP) G3GBZ0 (/IMP) |
|
Macrophage differentiation GO:0030225
The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.
|
4 | E7FF48 (/IMP) F1R8E1 (/IMP) F1R8Z8 (/IMP) G3GBZ0 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
4 | O75376 (/ISS) O75376 (/ISS) Q4KKX4 (/ISS) Q8QG78 (/ISS) |
|
Hematopoietic stem cell differentiation GO:0060218
The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
|
4 | E7FF48 (/IGI) F1R8E1 (/IGI) F1R8Z8 (/IGI) G3GBZ0 (/IGI) |
|
Hematopoietic stem cell differentiation GO:0060218
The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
|
4 | E7FF48 (/IMP) F1R8E1 (/IMP) F1R8Z8 (/IMP) G3GBZ0 (/IMP) |
|
Negative regulation of androgen receptor signaling pathway GO:0060766
Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway.
|
4 | O75376 (/IMP) O75376 (/IMP) Q9Y618 (/IMP) Q9Y618 (/IMP) |
|
Negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799
Any process that stops, prevents or reduces the frequency, rate or extent of production of miRNAs involved in gene silencing by miRNA.
|
4 | O75376 (/IMP) O75376 (/IMP) Q9Y618 (/IMP) Q9Y618 (/IMP) |
|
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
|
3 | M9PGZ8 (/IMP) Q9U4I2 (/IMP) Q9VYK0 (/IMP) |
|
Ovarian follicle cell development GO:0030707
The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster.
|
3 | M9PGZ8 (/IMP) Q9U4I2 (/IMP) Q9VYK0 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q60974 (/IGI) Q9WU42 (/IGI) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q60974 (/ISO) Q9WU42 (/ISO) |
|
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
|
2 | O75376 (/TAS) O75376 (/TAS) |
|
Lactation GO:0007595
The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
|
2 | A0A0G2JU91 (/IEP) D3ZXN9 (/IEP) |
|
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
|
2 | O75376 (/TAS) O75376 (/TAS) |
|
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
|
2 | A3QK40 (/IMP) A8B6H7 (/IMP) |
|
Response to organonitrogen compound GO:0010243
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.
|
2 | A0A0G2JU91 (/IEP) D3ZXN9 (/IEP) |
|
Hindbrain development GO:0030902
The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).
|
2 | A3QK40 (/IMP) A8B6H7 (/IMP) |
|
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
|
2 | A0A0G2JU91 (/IEP) D3ZXN9 (/IEP) |
|
Estrous cycle GO:0044849
A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur.
|
2 | A0A0G2JU91 (/IEP) D3ZXN9 (/IEP) |
|
Locomotor rhythm GO:0045475
The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.
|
2 | O75376 (/ISS) O75376 (/ISS) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q60974 (/IDA) Q9WU42 (/IDA) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q60974 (/ISO) Q9WU42 (/ISO) |
|
Negative regulation of JNK cascade GO:0046329
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade.
|
2 | O75376 (/IDA) O75376 (/IDA) |
|
Spindle assembly GO:0051225
The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.
|
2 | O75376 (/IMP) O75376 (/IMP) |
|
Negative regulation of androgen receptor signaling pathway GO:0060766
Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway.
|
2 | Q60974 (/ISO) Q9WU42 (/ISO) |
|
Regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter GO:0072362
Any process that modulates the frequency, rate or extent of glycolysis by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | O75376 (/IMP) O75376 (/IMP) |
|
Regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter GO:0072365
Any process that modulates the frequency, rate or extent of a cellular ketone metabolic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | Q9Y618 (/IMP) Q9Y618 (/IMP) |
|
Regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter GO:0072368
Any process that modulates the frequency, rate or extent of lipid transport by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | O75376 (/IMP) O75376 (/IMP) |
|
Negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799
Any process that stops, prevents or reduces the frequency, rate or extent of production of miRNAs involved in gene silencing by miRNA.
|
2 | Q60974 (/ISO) Q9WU42 (/ISO) |
|
Regulation of fatty acid transport GO:2000191
Any process that modulates the frequency, rate or extent of fatty acid transport.
|
2 | O75376 (/IC) O75376 (/IC) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q9WU42 (/IDA) |
|
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
|
1 | Q9WU42 (/IMP) |
|
Regulation of thyroid hormone mediated signaling pathway GO:0002155
Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway.
|
1 | Q60974 (/IGI) |
|
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation GO:0002361
The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell.
|
1 | Q60974 (/IMP) |
|
Heart morphogenesis GO:0003007
The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
1 | Q9WU42 (/IGI) |
|
Heart morphogenesis GO:0003007
The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
1 | Q9WU42 (/IMP) |
|
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
1 | Q10369 (/IPI) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q60974 (/IGI) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | Q60974 (/ISO) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | Q60974 (/ISO) |
|
Negative regulation of phosphatidylinositol 3-kinase signaling GO:0014067
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
|
1 | Q60974 (/IMP) |
|
Histone deacetylation GO:0016575
The modification of histones by removal of acetyl groups.
|
1 | Q10369 (/ISO) |
|
Telencephalon development GO:0021537
The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived.
|
1 | Q9WU42 (/IMP) |
|
Thalamus development GO:0021794
The process in which the thalamus changes over time, from its initial formation to its mature state.
|
1 | Q60974 (/IMP) |
|
Cell proliferation in forebrain GO:0021846
The creation of greater cell numbers in the forebrain due to cell division of progenitor cells.
|
1 | Q9WU42 (/IMP) |
|
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
|
1 | Q9WU42 (/IMP) |
|
Positive regulation of histone deacetylation GO:0031065
Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones.
|
1 | Q60974 (/IDA) |
|
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
|
1 | Q60974 (/IGI) |
|
Wing disc development GO:0035220
Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura.
|
1 | M9PGZ8 (/IMP) |
|
Regulation of multicellular organism growth GO:0040014
Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
|
1 | Q60974 (/IGI) |
|
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
|
1 | Q9WU42 (/IMP) |
|
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
|
1 | Q60974 (/IMP) |
|
Locomotor rhythm GO:0045475
The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.
|
1 | Q60974 (/IMP) |
|
Negative regulation of fat cell differentiation GO:0045599
Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation.
|
1 | Q9WU42 (/IMP) |
|
Negative regulation of Notch signaling pathway GO:0045746
Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
|
1 | M9PGZ8 (/IMP) |
|
Negative regulation of JNK cascade GO:0046329
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade.
|
1 | Q60974 (/ISO) |
|
White fat cell differentiation GO:0050872
The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole.
|
1 | Q9WU42 (/IMP) |
|
Spindle assembly GO:0051225
The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.
|
1 | Q60974 (/ISO) |
|
Definitive erythrocyte differentiation GO:0060318
Erythrocyte differentiation which occurs as part of the process of definitive hemopoiesis.
|
1 | Q60974 (/IMP) |
|
Type I pneumocyte differentiation GO:0060509
The process in which a relatively unspecialized cell acquires specialized features of a type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles.
|
1 | Q9WU42 (/IGI) |
|
Type I pneumocyte differentiation GO:0060509
The process in which a relatively unspecialized cell acquires specialized features of a type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles.
|
1 | Q9WU42 (/IMP) |
|
Heterochromatin assembly involved in chromatin silencing GO:0070869
Any process that results in the assembly of chromatin into heterochromatin and contributes to chromatin silencing.
|
1 | Q10369 (/IC) |
|
Regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter GO:0072362
Any process that modulates the frequency, rate or extent of glycolysis by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q60974 (/ISO) |
|
Regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter GO:0072365
Any process that modulates the frequency, rate or extent of a cellular ketone metabolic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q9WU42 (/ISO) |
|
Regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter GO:0072368
Any process that modulates the frequency, rate or extent of lipid transport by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q60974 (/ISO) |
|
Positive regulation of protein deacetylation GO:0090312
Any process that increases the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic
|
1 | Q9WU42 (/IDA) |
|
Cellular response to Thyroglobulin triiodothyronine GO:1904017
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroglobulin triiodothyronine stimulus.
|
1 | Q60974 (/IGI) |
There are 37 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
18 |
A0A024RD47 (/IDA)
A0A024RD47 (/IDA)
A0A088AWL3 (/IDA)
C9J0Q5 (/IDA)
C9JE98 (/IDA)
C9JFD3 (/IDA)
C9JFD3 (/IDA)
C9JQE8 (/IDA)
E7EVU5 (/IDA)
E7EVU5 (/IDA)
(8 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
11 |
A0A024RD47 (/IDA)
A0A024RD47 (/IDA)
A0A088AWL3 (/IDA)
E7EVU5 (/IDA)
E7EVU5 (/IDA)
E7EW50 (/IDA)
E7EW50 (/IDA)
J3KS51 (/IDA)
J3KS51 (/IDA)
O75376 (/IDA)
(1 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
7 | A0A0G2JU91 (/IDA) D3ZXN9 (/IDA) O75376 (/IDA) O75376 (/IDA) Q60974 (/IDA) Q9Y618 (/IDA) Q9Y618 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
6 | O75376 (/TAS) O75376 (/TAS) Q60974 (/TAS) Q9WU42 (/TAS) Q9Y618 (/TAS) Q9Y618 (/TAS) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
4 | O75376 (/IDA) O75376 (/IDA) Q9Y618 (/IDA) Q9Y618 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | O75376 (/IC) O75376 (/IC) Q9Y618 (/IC) Q9Y618 (/IC) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
4 | O75376 (/HDA) O75376 (/HDA) Q9Y618 (/HDA) Q9Y618 (/HDA) |
|
Transcriptional repressor complex GO:0017053
A protein complex that possesses activity that prevents or downregulates transcription.
|
4 | O75376 (/IDA) O75376 (/IDA) Q9Y618 (/IDA) Q9Y618 (/IDA) |
|
Transcriptional repressor complex GO:0017053
A protein complex that possesses activity that prevents or downregulates transcription.
|
4 | M9PGZ8 (/IPI) Q60974 (/IPI) Q9U4I2 (/IPI) Q9VYK0 (/IPI) |
|
Histone deacetylase complex GO:0000118
A protein complex that possesses histone deacetylase activity.
|
3 | O75376 (/IDA) O75376 (/IDA) Q9WU42 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | M9PGZ8 (/HDA) Q9U4I2 (/HDA) Q9VYK0 (/HDA) |
|
Polytene chromosome GO:0005700
A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.
|
3 | M9PGZ8 (/NAS) Q9U4I2 (/NAS) Q9VYK0 (/NAS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | M9PGZ8 (/HDA) Q9U4I2 (/HDA) Q9VYK0 (/HDA) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
3 | Q9WU42 (/IDA) Q9Y618 (/IDA) Q9Y618 (/IDA) |
|
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
|
2 | A0A0G2JU91 (/IDA) D3ZXN9 (/IDA) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
2 | Q60974 (/ISO) Q9WU42 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q60974 (/ISO) Q9WU42 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q60974 (/ISO) Q9WU42 (/ISO) |
|
Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
|
2 | Q9Y618 (/IDA) Q9Y618 (/IDA) |
|
Transcriptional repressor complex GO:0017053
A protein complex that possesses activity that prevents or downregulates transcription.
|
2 | Q60974 (/ISO) Q9WU42 (/ISO) |
|
Mitotic spindle GO:0072686
A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
|
2 | O75376 (/IDA) O75376 (/IDA) |
|
Histone deacetylase complex GO:0000118
A protein complex that possesses histone deacetylase activity.
|
1 | Q60974 (/ISO) |
|
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
|
1 | Q9WU42 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q10369 (/HDA) |
|
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
1 | Q60974 (/IPI) |
|
Polytene chromosome GO:0005700
A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.
|
1 | M9PGZ8 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q60974 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q60974 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q60974 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q60974 (/TAS) |
|
Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
|
1 | Q9WU42 (/ISO) |
|
Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
|
1 | Q9WU42 (/ISS) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
1 | Q9WU42 (/ISO) |
|
Set3 complex GO:0034967
A histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Set3p, Snt1p, Hos4p, Sif2p, Cpr1p, Hos2p, and Hst1p.
|
1 | Q10369 (/IDA) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
1 | Q60974 (/ISO) |
|
Rpd3L-Expanded complex GO:0070210
A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins.
|
1 | Q10369 (/IDA) |
|
Mitotic spindle GO:0072686
A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
|
1 | Q60974 (/ISO) |
