The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Homeodomain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 257: Zinc-finger homeodomain protein 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
19 O64722 (/IPI) O64722 (/IPI) Q9FIW9 (/IPI) Q9FKJ9 (/IPI) Q9FKP8 (/IPI) Q9FRL5 (/IPI) Q9FRL5 (/IPI) Q9LHF0 (/IPI) Q9LXG0 (/IPI) Q9LXG0 (/IPI)
(9 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
17 O64722 (/ISS) O64722 (/ISS) Q9FIW9 (/ISS) Q9FKJ9 (/ISS) Q9FKP8 (/ISS) Q9LHF0 (/ISS) Q9LXG0 (/ISS) Q9LXG0 (/ISS) Q9M9S0 (/ISS) Q9M9S0 (/ISS)
(7 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
14 O64722 (/ISS) O64722 (/ISS) Q9FIW9 (/ISS) Q9FKJ9 (/ISS) Q9LHF0 (/ISS) Q9LXG0 (/ISS) Q9LXG0 (/ISS) Q9SB61 (/ISS) Q9SB61 (/ISS) Q9SEZ1 (/ISS)
(4 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
9 Q9FIW9 (/IDA) Q9FRL5 (/IDA) Q9FRL5 (/IDA) Q9M9S0 (/IDA) Q9M9S0 (/IDA) Q9SB61 (/IDA) Q9SB61 (/IDA) Q9SEZ1 (/IDA) Q9SEZ1 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
7 O64722 (/IPI) O64722 (/IPI) Q9FRL5 (/IPI) Q9FRL5 (/IPI) Q9LHF0 (/IPI) Q9LXG0 (/IPI) Q9LXG0 (/IPI)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
4 Q9FRL5 (/IDA) Q9FRL5 (/IDA) Q9SEZ1 (/IDA) Q9SEZ1 (/IDA)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
3 Q9LHF0 (/IPI) Q9LXG0 (/IPI) Q9LXG0 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 Q9SEZ1 (/IDA) Q9SEZ1 (/IDA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 Q9FIW9 (/IPI)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glucosinolate metabolic process GO:0019760
The chemical reactions and pathways involving glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in animals and humans.
5 O64722 (/IMP) O64722 (/IMP) Q9LHF0 (/IMP) Q9LXG0 (/IMP) Q9LXG0 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
4 Q9FRL5 (/IDA) Q9FRL5 (/IDA) Q9SEZ1 (/IDA) Q9SEZ1 (/IDA)
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
2 Q9SEZ1 (/IMP) Q9SEZ1 (/IMP)
Response to abscisic acid GO:0009737
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
2 Q9FRL5 (/IMP) Q9FRL5 (/IMP)
Embryo development ending in seed dormancy GO:0009793
The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana.
2 Q9SB61 (/IMP) Q9SB61 (/IMP)
Long-day photoperiodism, flowering GO:0048574
A change from the vegetative to the reproductive phase as a result of detection of, or exposure to, a period of light that exceeds the critical day length. The critical day length varies between species. Although the term is long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 minus the critical day length.
2 Q9M9S0 (/IEP) Q9M9S0 (/IEP)
DNA-templated transcriptional start site selection GO:0001173
Any process involved in the selection of the specific location within the template strand of a DNA-dependent RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.
1 Q9FIW9 (/IEP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9FKP8 (/IMP)
Response to blue light GO:0009637
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm.
1 Q9FIW9 (/IDA)
Response to gibberellin GO:0009739
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus.
1 Q9FIW9 (/IEP)
Regulation of gibberellin biosynthetic process GO:0010371
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins.
1 Q9FKP8 (/IMP)
Seed maturation GO:0010431
A process in seed development that occurs after embryogenesis by which a quiescent state is established in a seed. Seed maturation is characterized by storage compound accumulation, acquisition of desiccation tolerance, growth arrest and the entry into a dormancy period of variable length that is broken upon germination.
1 Q9FKP8 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9FIW9 (/IEP)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
17 O64722 (/ISS) O64722 (/ISS) Q9FIW9 (/ISS) Q9FKJ9 (/ISS) Q9FKP8 (/ISS) Q9LHF0 (/ISS) Q9LXG0 (/ISS) Q9LXG0 (/ISS) Q9M9S0 (/ISS) Q9M9S0 (/ISS)
(7 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q9FIW9 (/IDA) Q9FRL5 (/IDA) Q9FRL5 (/IDA)
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