The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Homeodomain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 213: Homeodomain-only protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 Q8R1H0 (/IPI) Q8R1H0 (/IPI) Q9BPY8 (/IPI) Q9BPY8 (/IPI) Q9BPY8 (/IPI) Q9BPY8 (/IPI)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 Q9BPY8 (/ISA) Q9BPY8 (/ISA) Q9BPY8 (/ISA) Q9BPY8 (/ISA)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Trophectodermal cell differentiation GO:0001829
The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell.
4 Q9BPY8 (/IDA) Q9BPY8 (/IDA) Q9BPY8 (/IDA) Q9BPY8 (/IDA)
Negative regulation of cell differentiation GO:0045596
Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation.
4 Q9BPY8 (/IDA) Q9BPY8 (/IDA) Q9BPY8 (/IDA) Q9BPY8 (/IDA)
Chaperone-mediated protein complex assembly GO:0051131
The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex.
4 Q9BPY8 (/IDA) Q9BPY8 (/IDA) Q9BPY8 (/IDA) Q9BPY8 (/IDA)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
3 Q8AYB8 (/IMP) Q8R1H0 (/IMP) Q8R1H0 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 Q8R1H0 (/IDA) Q8R1H0 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 Q8R1H0 (/IGI) Q8R1H0 (/IGI)
Trophectodermal cell differentiation GO:0001829
The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell.
2 Q8R1H0 (/IMP) Q8R1H0 (/IMP)
Trophectodermal cell differentiation GO:0001829
The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell.
2 Q8R1H0 (/ISO) Q8R1H0 (/ISO)
Regulation of heart contraction GO:0008016
Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.
2 Q8R1H0 (/IMP) Q8R1H0 (/IMP)
Histone deacetylation GO:0016575
The modification of histones by removal of acetyl groups.
2 Q8R1H0 (/IGI) Q8R1H0 (/IGI)
Regulation of protein binding GO:0043393
Any process that modulates the frequency, rate or extent of protein binding.
2 Q8R1H0 (/IDA) Q8R1H0 (/IDA)
Positive regulation of skeletal muscle tissue regeneration GO:0043415
Any process that activates or increase the rate of skeletal muscle regeneration.
2 Q8R1H0 (/IMP) Q8R1H0 (/IMP)
Negative regulation of cell differentiation GO:0045596
Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation.
2 Q8R1H0 (/ISO) Q8R1H0 (/ISO)
Lung alveolus development GO:0048286
The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways.
2 Q8R1H0 (/IMP) Q8R1H0 (/IMP)
Chaperone-mediated protein complex assembly GO:0051131
The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex.
2 Q8R1H0 (/ISO) Q8R1H0 (/ISO)
Positive regulation of striated muscle cell differentiation GO:0051155
Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation.
2 Q8R1H0 (/IMP) Q8R1H0 (/IMP)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 Q8R1H0 (/IDA) Q8R1H0 (/IDA) Q9BPY8 (/IDA) Q9BPY8 (/IDA) Q9BPY8 (/IDA) Q9BPY8 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q8R1H0 (/ISO) Q8R1H0 (/ISO)
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