The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Homeodomain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 19: Ligand-dependent corepressor isoform 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
41 A0A126GUM1 (/IDA) A0A126GUM1 (/IDA) A0A126GUM1 (/IDA) A0A126GUM1 (/IDA) A1Z8A4 (/IDA) A1Z8A4 (/IDA) A1Z8A4 (/IDA) A1Z8A4 (/IDA) A1Z8A6 (/IDA) A1Z8A6 (/IDA)
(31 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
40 A0A126GUM1 (/IDA) A0A126GUM1 (/IDA) A0A126GUM1 (/IDA) A0A126GUM1 (/IDA) A1Z8A4 (/IDA) A1Z8A4 (/IDA) A1Z8A4 (/IDA) A1Z8A4 (/IDA) A1Z8A6 (/IDA) A1Z8A6 (/IDA)
(30 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
40 A0A126GUM1 (/TAS) A0A126GUM1 (/TAS) A0A126GUM1 (/TAS) A0A126GUM1 (/TAS) A1Z8A4 (/TAS) A1Z8A4 (/TAS) A1Z8A4 (/TAS) A1Z8A4 (/TAS) A1Z8A6 (/TAS) A1Z8A6 (/TAS)
(30 more)
POZ domain binding GO:0031208
Interacting selectively and non-covalently with a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors.
40 A0A126GUM1 (/IDA) A0A126GUM1 (/IDA) A0A126GUM1 (/IDA) A0A126GUM1 (/IDA) A1Z8A4 (/IDA) A1Z8A4 (/IDA) A1Z8A4 (/IDA) A1Z8A4 (/IDA) A1Z8A6 (/IDA) A1Z8A6 (/IDA)
(30 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
40 A0A126GUM1 (/IDA) A0A126GUM1 (/IDA) A0A126GUM1 (/IDA) A0A126GUM1 (/IDA) A1Z8A4 (/IDA) A1Z8A4 (/IDA) A1Z8A4 (/IDA) A1Z8A4 (/IDA) A1Z8A6 (/IDA) A1Z8A6 (/IDA)
(30 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
5 Q8N3X6 (/ISM) Q8N3X6 (/ISM) Q96JN0 (/ISM) Q96JN0 (/ISM) Q96JN0 (/ISM)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
5 Q8N3X6 (/NAS) Q8N3X6 (/NAS) Q96JN0 (/NAS) Q96JN0 (/NAS) Q96JN0 (/NAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 Q8N3X6 (/IPI) Q8N3X6 (/IPI) Q96JN0 (/IPI) Q96JN0 (/IPI) Q96JN0 (/IPI)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
2 Q6ZPI3 (/IDA) Q6ZPI3 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
2 A0A0B4KFC4 (/TAS) Q7KF43 (/TAS)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
2 Q6ZPI3 (/IPI) Q6ZPI3 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q95YM8 (/NAS)

There are 40 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chromatin silencing GO:0006342
Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
40 A0A126GUM1 (/IMP) A0A126GUM1 (/IMP) A0A126GUM1 (/IMP) A0A126GUM1 (/IMP) A1Z8A4 (/IMP) A1Z8A4 (/IMP) A1Z8A4 (/IMP) A1Z8A4 (/IMP) A1Z8A6 (/IMP) A1Z8A6 (/IMP)
(30 more)
Pole plasm assembly GO:0007315
Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster.
40 A0A126GUM1 (/NAS) A0A126GUM1 (/NAS) A0A126GUM1 (/NAS) A0A126GUM1 (/NAS) A1Z8A4 (/NAS) A1Z8A4 (/NAS) A1Z8A4 (/NAS) A1Z8A4 (/NAS) A1Z8A6 (/NAS) A1Z8A6 (/NAS)
(30 more)
Imaginal disc-derived wing morphogenesis GO:0007476
The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying.
40 A0A126GUM1 (/IMP) A0A126GUM1 (/IMP) A0A126GUM1 (/IMP) A0A126GUM1 (/IMP) A1Z8A4 (/IMP) A1Z8A4 (/IMP) A1Z8A4 (/IMP) A1Z8A4 (/IMP) A1Z8A6 (/IMP) A1Z8A6 (/IMP)
(30 more)
Anterior/posterior axis specification, embryo GO:0008595
The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote.
40 A0A126GUM1 (/HMP) A0A126GUM1 (/HMP) A0A126GUM1 (/HMP) A0A126GUM1 (/HMP) A1Z8A4 (/HMP) A1Z8A4 (/HMP) A1Z8A4 (/HMP) A1Z8A4 (/HMP) A1Z8A6 (/HMP) A1Z8A6 (/HMP)
(30 more)
Embryonic pattern specification GO:0009880
The process that results in the patterns of cell differentiation that will arise in an embryo.
40 A0A126GUM1 (/IMP) A0A126GUM1 (/IMP) A0A126GUM1 (/IMP) A0A126GUM1 (/IMP) A1Z8A4 (/IMP) A1Z8A4 (/IMP) A1Z8A4 (/IMP) A1Z8A4 (/IMP) A1Z8A6 (/IMP) A1Z8A6 (/IMP)
(30 more)
Gene silencing GO:0016458
Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression.
40 A0A126GUM1 (/TAS) A0A126GUM1 (/TAS) A0A126GUM1 (/TAS) A0A126GUM1 (/TAS) A1Z8A4 (/TAS) A1Z8A4 (/TAS) A1Z8A4 (/TAS) A1Z8A4 (/TAS) A1Z8A6 (/TAS) A1Z8A6 (/TAS)
(30 more)
Regulation of chromatin silencing GO:0031935
Any process that affects the rate, extent or location of chromatin silencing.
40 A0A126GUM1 (/IMP) A0A126GUM1 (/IMP) A0A126GUM1 (/IMP) A0A126GUM1 (/IMP) A1Z8A4 (/IMP) A1Z8A4 (/IMP) A1Z8A4 (/IMP) A1Z8A4 (/IMP) A1Z8A6 (/IMP) A1Z8A6 (/IMP)
(30 more)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
3 Q3U285 (/IDA) Q6ZPI3 (/IDA) Q6ZPI3 (/IDA)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
3 Q3U285 (/IDA) Q6ZPI3 (/IDA) Q6ZPI3 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
3 A0A0B4KHV1 (/TAS) Q7YU18 (/TAS) Q9VD60 (/TAS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 Q6ZPI3 (/IDA) Q6ZPI3 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 Q6ZPI3 (/IMP) Q6ZPI3 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
2 A0A0B4KFC4 (/TAS) Q7KF43 (/TAS)
Cytoskeleton organization GO:0007010
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
2 A0A0B4KFC4 (/TAS) Q7KF43 (/TAS)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
2 A0A0B4KFC4 (/IMP) Q7KF43 (/IMP)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
2 A0A0B4KFC4 (/NAS) Q7KF43 (/NAS)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
2 A0A0B4KFC4 (/TAS) Q7KF43 (/TAS)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
2 A0A0B4KFC4 (/IMP) Q7KF43 (/IMP)
Open tracheal system development GO:0007424
The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster.
2 A0A0B4KFC4 (/IMP) Q7KF43 (/IMP)
Open tracheal system development GO:0007424
The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster.
2 A0A0B4KFC4 (/NAS) Q7KF43 (/NAS)
Open tracheal system development GO:0007424
The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster.
2 A0A0B4KFC4 (/TAS) Q7KF43 (/TAS)
Tracheal outgrowth, open tracheal system GO:0007426
The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster.
2 A0A0B4KFC4 (/IMP) Q7KF43 (/IMP)
Epithelial cell migration, open tracheal system GO:0007427
The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster.
2 A0A0B4KFC4 (/IMP) Q7KF43 (/IMP)
Salivary gland development GO:0007431
The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity.
2 A0A0B4KFC4 (/TAS) Q7KF43 (/TAS)
Salivary gland morphogenesis GO:0007435
The process in which the anatomical structures of the salivary gland are generated and organized.
2 A0A0B4KFC4 (/IMP) Q7KF43 (/IMP)
Salivary gland morphogenesis GO:0007435
The process in which the anatomical structures of the salivary gland are generated and organized.
2 A0A0B4KFC4 (/NAS) Q7KF43 (/NAS)
Hindgut morphogenesis GO:0007442
The process in which the anatomical structures of the hindgut are generated and organized.
2 A0A0B4KFC4 (/IMP) Q7KF43 (/IMP)
Malpighian tubule morphogenesis GO:0007443
The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut.
2 A0A0B4KFC4 (/IMP) Q7KF43 (/IMP)
Protein localization GO:0008104
Any process in which a protein is transported to, or maintained in, a specific location.
2 A0A0B4KFC4 (/IMP) Q7KF43 (/IMP)
Head involution GO:0008258
Movement of the anterior ectoderm to the interior of the embryo.
2 A0A0B4KFC4 (/IMP) Q7KF43 (/IMP)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
2 A0A0B4KFC4 (/IMP) Q7KF43 (/IMP)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
2 A0A0B4KFC4 (/TAS) Q7KF43 (/TAS)
Gonad development GO:0008406
The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.
2 A0A0B4KFC4 (/IMP) Q7KF43 (/IMP)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
2 A0A0B4KFC4 (/TAS) Q7KF43 (/TAS)
Regulation of Malpighian tubule diameter GO:0035297
Ensuring that the Malpighian tubule is the correct width. Malpighian tubules have a uniform circumference along their length; the circumference of the tubes is eight cells during the time the cells are dividing, after which the cells rearrange producting tubes with a cirumference of two cells.
2 A0A0B4KFC4 (/IMP) Q7KF43 (/IMP)
Establishment or maintenance of epithelial cell apical/basal polarity GO:0045197
Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.
2 A0A0B4KFC4 (/IMP) Q7KF43 (/IMP)
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
2 A0A0B4KFC4 (/TAS) Q7KF43 (/TAS)
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
1 Q95YM8 (/NAS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q95YM8 (/IDA)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 Q7YU18 (/IMP)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
45 A0A0B4KFC4 (/IDA) A0A0B4KHV1 (/IDA) A0A126GUM1 (/IDA) A0A126GUM1 (/IDA) A0A126GUM1 (/IDA) A0A126GUM1 (/IDA) A1Z8A4 (/IDA) A1Z8A4 (/IDA) A1Z8A4 (/IDA) A1Z8A4 (/IDA)
(35 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
45 A0A0B4KFC4 (/TAS) A0A0B4KHV1 (/TAS) A0A126GUM1 (/TAS) A0A126GUM1 (/TAS) A0A126GUM1 (/TAS) A0A126GUM1 (/TAS) A1Z8A4 (/TAS) A1Z8A4 (/TAS) A1Z8A4 (/TAS) A1Z8A4 (/TAS)
(35 more)
PcG protein complex GO:0031519
A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure.
40 A0A126GUM1 (/IDA) A0A126GUM1 (/IDA) A0A126GUM1 (/IDA) A0A126GUM1 (/IDA) A1Z8A4 (/IDA) A1Z8A4 (/IDA) A1Z8A4 (/IDA) A1Z8A4 (/IDA) A1Z8A6 (/IDA) A1Z8A6 (/IDA)
(30 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 A0A0B4KHV1 (/NAS) Q7YU18 (/NAS) Q9VD60 (/NAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 Q96JN0 (/IDA) Q96JN0 (/IDA) Q96JN0 (/IDA)
Polytene chromosome GO:0005700
A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.
3 A0A0B4KHV1 (/NAS) Q7YU18 (/NAS) Q9VD60 (/NAS)
Polytene chromosome GO:0005700
A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.
3 A0A0B4KHV1 (/TAS) Q7YU18 (/TAS) Q9VD60 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q6ZPI3 (/ISO) Q6ZPI3 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q95YM8 (/IC)
CATH-Gene3D is a Global Biodata Core Resource Learn more...