The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Homeodomain-like
".
FunFam 17: Homeobox protein antennapedia
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 19 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
31 |
P09629 (/ISA)
P09630 (/ISA)
P09630 (/ISA)
P09630 (/ISA)
P09630 (/ISA)
P09630 (/ISA)
P09630 (/ISA)
P09630 (/ISA)
P09630 (/ISA)
P09630 (/ISA)
(21 more) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
30 |
P09630 (/ISM)
P09630 (/ISM)
P09630 (/ISM)
P09630 (/ISM)
P09630 (/ISM)
P09630 (/ISM)
P09630 (/ISM)
P09630 (/ISM)
P09630 (/ISM)
P09630 (/ISM)
(20 more) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
30 |
P09630 (/NAS)
P09630 (/NAS)
P09630 (/NAS)
P09630 (/NAS)
P09630 (/NAS)
P09630 (/NAS)
P09630 (/NAS)
P09630 (/NAS)
P09630 (/NAS)
P09630 (/NAS)
(20 more) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
20 |
P09630 (/TAS)
P09630 (/TAS)
P09630 (/TAS)
P09630 (/TAS)
P09630 (/TAS)
P09630 (/TAS)
P09630 (/TAS)
P09630 (/TAS)
P09630 (/TAS)
P09630 (/TAS)
(10 more) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
4 | P02830 (/IDA) P02833 (/IDA) P02833 (/IDA) P09024 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | P09629 (/IPI) P17509 (/IPI) P17509 (/IPI) P17509 (/IPI) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
3 | P17509 (/HDA) P17509 (/HDA) P17509 (/HDA) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
3 | P02833 (/IDA) P02833 (/IDA) P31268 (/IDA) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
2 | P09629 (/IDA) P31268 (/IDA) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
2 | P02830 (/ISO) P09024 (/ISO) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | P02833 (/IDA) P02833 (/IDA) |
|
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | P09629 (/IDA) P31268 (/IDA) |
|
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | P02830 (/ISO) P09024 (/ISO) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | Q24645 (/ISS) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
1 | P02830 (/IDA) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
1 | P09629 (/NAS) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
1 | P31268 (/IPI) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
1 | P02830 (/ISO) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
1 | P02830 (/ISO) |
There are 44 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
|
28 |
P02830 (/IGI)
P09023 (/IGI)
P09023 (/IGI)
P09023 (/IGI)
P09023 (/IGI)
P09024 (/IGI)
P09092 (/IGI)
P09092 (/IGI)
P10629 (/IGI)
P10629 (/IGI)
(18 more) |
|
Embryonic skeletal system development GO:0048706
The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure.
|
26 |
P09023 (/IGI)
P09023 (/IGI)
P09023 (/IGI)
P09023 (/IGI)
P09092 (/IGI)
P09092 (/IGI)
P10629 (/IGI)
P10629 (/IGI)
P10629 (/IGI)
P10629 (/IGI)
(16 more) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
20 |
P09630 (/TAS)
P09630 (/TAS)
P09630 (/TAS)
P09630 (/TAS)
P09630 (/TAS)
P09630 (/TAS)
P09630 (/TAS)
P09630 (/TAS)
P09630 (/TAS)
P09630 (/TAS)
(10 more) |
|
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
|
20 |
P09630 (/TAS)
P09630 (/TAS)
P09630 (/TAS)
P09630 (/TAS)
P09630 (/TAS)
P09630 (/TAS)
P09630 (/TAS)
P09630 (/TAS)
P09630 (/TAS)
P09630 (/TAS)
(10 more) |
|
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
|
7 | P09023 (/IMP) P09023 (/IMP) P09023 (/IMP) P09023 (/IMP) P09024 (/IMP) P09092 (/IMP) P09092 (/IMP) |
|
Embryonic skeletal system morphogenesis GO:0048704
The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase.
|
6 | P02830 (/IGI) P09023 (/IGI) P09023 (/IGI) P09023 (/IGI) P09023 (/IGI) P09024 (/IGI) |
|
Erythrocyte homeostasis GO:0034101
Any process of regulating the production and elimination of erythrocytes within an organism.
|
4 | P09023 (/IMP) P09023 (/IMP) P09023 (/IMP) P09023 (/IMP) |
|
Embryonic skeletal system development GO:0048706
The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure.
|
4 | P09023 (/IMP) P09023 (/IMP) P09023 (/IMP) P09023 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | P02830 (/IDA) P09629 (/IDA) P31268 (/IDA) |
|
Embryonic skeletal system morphogenesis GO:0048704
The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase.
|
3 | P09024 (/IMP) P09092 (/IMP) P09092 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | P02830 (/IDA) P31268 (/IDA) |
|
Specification of segmental identity, antennal segment GO:0007383
The specification of the characteristic structures of the antennal segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized.
|
2 | P02833 (/IMP) P02833 (/IMP) |
|
Specification of segmental identity, thorax GO:0007384
The specification of the characteristic structures of the thoracic segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized.
|
2 | P02833 (/IMP) P02833 (/IMP) |
|
Specification of segmental identity, thorax GO:0007384
The specification of the characteristic structures of the thoracic segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized.
|
2 | P02833 (/TAS) P02833 (/TAS) |
|
Ventral cord development GO:0007419
The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms.
|
2 | P02833 (/HMP) P02833 (/HMP) |
|
Midgut development GO:0007494
The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine.
|
2 | P02833 (/TAS) P02833 (/TAS) |
|
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
2 | P02833 (/IEP) P02833 (/IEP) |
|
Anterior/posterior axis specification GO:0009948
The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
|
2 | P02833 (/IMP) P02833 (/IMP) |
|
Anterior/posterior axis specification GO:0009948
The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
|
2 | P02833 (/TAS) P02833 (/TAS) |
|
Neuroblast development GO:0014019
The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron.
|
2 | P02833 (/IMP) P02833 (/IMP) |
|
Muscle cell fate specification GO:0042694
The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
|
2 | P02833 (/IMP) P02833 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | P02833 (/IMP) P02833 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | P02830 (/ISO) P09024 (/ISO) |
|
Lymph gland development GO:0048542
The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages.
|
2 | P02833 (/IMP) P02833 (/IMP) |
|
Regulation of neurogenesis GO:0050767
Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.
|
2 | P02833 (/IMP) P02833 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | P02830 (/ISO) |
|
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
|
1 | P31268 (/IEP) |
|
Negative regulation of cell-matrix adhesion GO:0001953
Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix.
|
1 | P31268 (/IDA) |
|
Negative regulation of cell-matrix adhesion GO:0001953
Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix.
|
1 | P02830 (/ISO) |
|
Negative regulation of leukocyte migration GO:0002686
Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration.
|
1 | P31268 (/IDA) |
|
Negative regulation of leukocyte migration GO:0002686
Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration.
|
1 | P02830 (/ISO) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P09629 (/NAS) |
|
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
|
1 | P09629 (/NAS) |
|
Specification of segmental identity, thorax GO:0007384
The specification of the characteristic structures of the thoracic segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized.
|
1 | Q24645 (/ISS) |
|
Anterior/posterior axis specification GO:0009948
The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
|
1 | Q24645 (/ISS) |
|
Myeloid cell differentiation GO:0030099
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.
|
1 | P09024 (/IMP) |
|
Negative regulation of keratinocyte differentiation GO:0045617
Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation.
|
1 | P31268 (/IDA) |
|
Negative regulation of keratinocyte differentiation GO:0045617
Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation.
|
1 | P02830 (/ISO) |
|
Negative regulation of monocyte differentiation GO:0045656
Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation.
|
1 | P31268 (/IDA) |
|
Negative regulation of monocyte differentiation GO:0045656
Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation.
|
1 | P02830 (/ISO) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P31268 (/IDA) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P02830 (/ISO) |
|
Stem cell differentiation GO:0048863
The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
|
1 | P02830 (/IDA) |
|
Positive regulation of branching involved in ureteric bud morphogenesis GO:0090190
Any process that increases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.
|
1 | P09024 (/IMP) |
There are 13 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
22 |
P09629 (/IDA)
P09630 (/IDA)
P09630 (/IDA)
P09630 (/IDA)
P09630 (/IDA)
P09630 (/IDA)
P09630 (/IDA)
P09630 (/IDA)
P09630 (/IDA)
P09630 (/IDA)
(12 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
22 |
P02830 (/ISO)
P09024 (/ISO)
P10629 (/ISO)
P10629 (/ISO)
P10629 (/ISO)
P10629 (/ISO)
P10629 (/ISO)
P10629 (/ISO)
P10629 (/ISO)
P10629 (/ISO)
(12 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
21 |
P09629 (/IDA)
P09630 (/IDA)
P09630 (/IDA)
P09630 (/IDA)
P09630 (/IDA)
P09630 (/IDA)
P09630 (/IDA)
P09630 (/IDA)
P09630 (/IDA)
P09630 (/IDA)
(11 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
21 |
P09024 (/ISO)
P10629 (/ISO)
P10629 (/ISO)
P10629 (/ISO)
P10629 (/ISO)
P10629 (/ISO)
P10629 (/ISO)
P10629 (/ISO)
P10629 (/ISO)
P10629 (/ISO)
(11 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | P02830 (/IDA) P02833 (/IDA) P02833 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | P02833 (/IDA) P02833 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P31268 (/IC) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q24645 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P09629 (/NAS) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
1 | P09629 (/IDA) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
1 | P09024 (/ISO) |
|
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
|
1 | P31268 (/IDA) |
|
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
|
1 | P02830 (/ISO) |
