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CATH Superfamily 1.10.10.60

Homeodomain-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Homeodomain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 13: DNA-binding transcriptional activator MarA

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Bacterial-type proximal promoter sequence-specific DNA binding GO:0000986
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a bacterial gene (or cistron, or operon). The proximal promoter is in cis with and relatively close to the core promoter.
 170 P0A9E2 (/IDA) P0A9E2 (/IDA) P0A9E2 (/IDA) P0A9E2 (/IDA) P0A9E2 (/IDA) P0A9E2 (/IDA) P0A9E2 (/IDA) P0A9E2 (/IDA) P0A9E2 (/IDA) P0A9E2 (/IDA)
(160 more)
Bacterial-type RNA polymerase holo enzyme binding GO:0001108
Interacting selectively and non-covalently with the basal transcription machinery which is composed of a bacterial-type RNA polymerase core enzyme and a sigma factor, the minimal set of factors required for formation of the preinitiation complex (PIC) by a bacterial-type RNA polymerase.
 170 P0A9E2 (/IDA) P0A9E2 (/IDA) P0A9E2 (/IDA) P0A9E2 (/IDA) P0A9E2 (/IDA) P0A9E2 (/IDA) P0A9E2 (/IDA) P0A9E2 (/IDA) P0A9E2 (/IDA) P0A9E2 (/IDA)
(160 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
 143 P0ACI0 (/IDA) P0ACI0 (/IDA) P0ACI0 (/IDA) P0ACI0 (/IDA) P0ACI0 (/IDA) P0ACI0 (/IDA) P0ACI0 (/IDA) P0ACI0 (/IDA) P0ACI0 (/IDA) P0ACI0 (/IDA)
(133 more)
Bacterial-type RNA polymerase core promoter sequence-specific DNA binding GO:0000985
Interacting selectively and non-covalently with a DNA sequence that is part of the core promoter of a bacterial gene.
 103 P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP)
(93 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
 103 P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP)
(93 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
 103 P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA)
(93 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 103 P0ACH5 (/IPI) P0ACH5 (/IPI) P0ACH5 (/IPI) P0ACH5 (/IPI) P0ACH5 (/IPI) P0ACH5 (/IPI) P0ACH5 (/IPI) P0ACH5 (/IPI) P0ACH5 (/IPI) P0ACH5 (/IPI)
(93 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
 103 P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP)
(93 more)

There are 5 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
 170 P0A9E2 (/IMP) P0A9E2 (/IMP) P0A9E2 (/IMP) P0A9E2 (/IMP) P0A9E2 (/IMP) P0A9E2 (/IMP) P0A9E2 (/IMP) P0A9E2 (/IMP) P0A9E2 (/IMP) P0A9E2 (/IMP)
(160 more)
Cellular response to menadione GO:0036245
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position.
 103 P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA)
(93 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 103 P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP)
(93 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
 103 P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA)
(93 more)
Cellular response to paraquat GO:0072756
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paraquat stimulus.
 103 P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA) P0ACH5 (/IDA)
(93 more)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 143 P0ACI0 (/IDA) P0ACI0 (/IDA) P0ACI0 (/IDA) P0ACI0 (/IDA) P0ACI0 (/IDA) P0ACI0 (/IDA) P0ACI0 (/IDA) P0ACI0 (/IDA) P0ACI0 (/IDA) P0ACI0 (/IDA)
(133 more)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
 103 P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP)
(93 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 103 P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP) P0ACH5 (/IMP)
(93 more)
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