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CATH Superfamily 1.10.10.1590

NADH-quinone oxidoreductase subunit E

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NADH-quinone oxidoreductase subunit E
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: NADH-quinone oxidoreductase subunit E

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
NADH dehydrogenase. [EC: 1.6.99.3]
NADH + acceptor = NAD(+) + reduced acceptor.
  • After preparations have been subjected to certain treatments cytochrome c may act as acceptor.
  • Under normal conditions, two protons are extruded from the cytoplasm or the intramitochondrial or stromal compartment.
  • Present in a mitochondrial complex as EC 7.1.1.2.
  • Formerly EC 1.6.2.1.
 15 K7CT02 K7CT02 O22769 P04394 P19234 P19404 Q0MQI7 Q0MQI7 Q0MQI8 Q0MQI8
(5 more...)
NADH:ubiquinone reductase (H(+)-translocating). [EC: 7.1.1.2]
NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out).
  • The complex is present in mitochondria and aerobic bacteria.
  • Breakdown of the complex can release EC 1.6.99.3.
  • In photosynthetic bacteria, reversed electron transport through this enzyme can reduce NAD(+) to NADH.
  • Formerly EC 1.6.5.3.
 15 K7CT02 K7CT02 O22769 P04394 P19234 P19404 Q0MQI7 Q0MQI7 Q0MQI8 Q0MQI8
(5 more...)
Hydrogen dehydrogenase (NADP(+)). [EC: 1.12.1.3]
H(2) + NADP(+) = H(+) + NADPH.
  • The protein from the bacterium Desulfovibrio fructosovorans exclusively functions as a hydrogen dehydrogenase, while the enzyme from the archaeon Pyrococcus furiosus is part of a heterotetrameric complex where the alpha and delta subunits function as a hydrogenase while the beta and gamma subunits function as sulfur reductase (EC 1.12.98.4).
  • Different from EC 1.12.1.5.
 4 E1JRZ9 E1JRZ9 Q46505 Q46505