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CATH Superfamily 1.10.10.1420

DNA replication factor Cdt1, C-terminal WH domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
DNA replication factor Cdt1, C-terminal WH domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: DNA replication factor Cdt1, C-terminal WH domain

In eukaryotic replication licensing, Cdt1 plays a key role by recruiting the MCM2-7 complex onto the origin of chromosome. This superfamily entry represents the C-terminal domain of Cdt1 (mCdt1C characterised in mice). It is the most conserved region in Cdt1, is essential for licensing and directly interacts with the MCM2-7 complex PMID:19722278. The C-terminal region contains a WHD (winged helix domain), a typical DNA recognition motif PMID:20335175. The winged-helix fold is conserved throughout several other licensing factors, suggesting that they evolved from a common ancestor. In mouse Cdt1 (mCdt1C) the main role of the WH motif is to interact with MCM2-7 rather than with the DNA, as other winged-helix domains.

PFAM:PF16679,INTERPRO:IPR032054,DOI:10.1002/pro.236,DOI:10.1074/jbc.M109.075333

GO Diversity

Unique GO annotations
55 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1165 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 3
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 2
Unique PDBs: 3
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 11
Function
Unique EC:
Unique GO: 55
Taxonomy
Unique Species: 1165