The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Dcp2, box A domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: M7GpppN-mRNA hydrolase isoform 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
M7G(5')pppN diphosphatase activity GO:0050072
Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide.
4 Q5U127 (/IDA) Q86NM7 (/IDA) Q8IU60 (/IDA) Q9VUU4 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q5U127 (/IPI) Q8IU60 (/IPI)
M7G(5')pppN diphosphatase activity GO:0050072
Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide.
2 Q5REQ8 (/ISS) Q9CYC6 (/ISS)
5'-3' exoribonuclease activity GO:0004534
Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule.
1 Q8IU60 (/IMP)
5'-3' exoribonuclease activity GO:0004534
Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule.
1 Q9CYC6 (/ISO)
Exoribonuclease activity, producing 5'-phosphomonoesters GO:0016896
Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters.
1 Q8IU60 (/TAS)
M7G(5')pppN diphosphatase activity GO:0050072
Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide.
1 Q9CYC6 (/ISO)
Telomerase RNA binding GO:0070034
Interacting selectively and non-covalently with the telomerase RNA template.
1 Q8IU60 (/IC)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Deadenylation-dependent decapping of nuclear-transcribed mRNA GO:0000290
Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length.
3 Q5U127 (/IDA) Q86NM7 (/IDA) Q9VUU4 (/IDA)
Nuclear-transcribed mRNA catabolic process GO:0000956
The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells.
3 Q5U127 (/IMP) Q86NM7 (/IMP) Q9VUU4 (/IMP)
MRNA catabolic process GO:0006402
The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
3 Q6NYI8 (/IMP) Q803B9 (/IMP) Q9CYC6 (/IMP)
Regulation of cytoplasmic mRNA processing body assembly GO:0010603
Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.
3 Q5U127 (/IMP) Q86NM7 (/IMP) Q9VUU4 (/IMP)
Gene silencing by miRNA GO:0035195
Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA.
3 Q5U127 (/IMP) Q86NM7 (/IMP) Q9VUU4 (/IMP)
MRNA catabolic process GO:0006402
The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
2 Q5REQ8 (/ISS) Q9CYC6 (/ISS)
Regulation of mRNA stability GO:0043488
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
2 Q5REQ8 (/ISS) Q9CYC6 (/ISS)
Histone mRNA catabolic process GO:0071044
The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA).
2 Q5REQ8 (/ISS) Q9CYC6 (/ISS)
MRNA catabolic process GO:0006402
The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
1 Q8IU60 (/IDA)
MRNA catabolic process GO:0006402
The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
1 Q9CYC6 (/ISO)
Negative regulation of telomere maintenance via telomerase GO:0032211
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase.
1 Q8IU60 (/IMP)
Negative regulation of telomere maintenance via telomerase GO:0032211
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase.
1 Q9CYC6 (/ISO)
Regulation of mRNA stability GO:0043488
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
1 Q8IU60 (/IDA)
Regulation of mRNA stability GO:0043488
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
1 Q9CYC6 (/ISO)
Regulation of mRNA stability GO:0043488
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
1 Q8IU60 (/TAS)
Exonucleolytic catabolism of deadenylated mRNA GO:0043928
The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail.
1 Q8IU60 (/TAS)
Histone mRNA catabolic process GO:0071044
The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA).
1 Q8IU60 (/IMP)
Histone mRNA catabolic process GO:0071044
The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA).
1 Q9CYC6 (/ISO)
Regulation of telomerase RNA localization to Cajal body GO:1904872
Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body.
1 Q8IU60 (/IMP)
Regulation of telomerase RNA localization to Cajal body GO:1904872
Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body.
1 Q9CYC6 (/ISO)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
4 Q5U127 (/IDA) Q86NM7 (/IDA) Q8IU60 (/IDA) Q9VUU4 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q5U127 (/IDA) Q86NM7 (/IDA) Q9VUU4 (/IDA)
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
1 Q9CYC6 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q8IU60 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9CYC6 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8IU60 (/TAS)
RISC complex GO:0016442
A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation.
1 Q8IU60 (/IDA)
RISC complex GO:0016442
A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation.
1 Q9CYC6 (/ISO)
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
1 Q8IU60 (/IDA)
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
1 Q9CYC6 (/ISO)
Cytoplasmic ribonucleoprotein granule GO:0036464
A ribonucleoprotein granule located in the cytoplasm.
1 Q8IU60 (/IDA)
Cytoplasmic ribonucleoprotein granule GO:0036464
A ribonucleoprotein granule located in the cytoplasm.
1 Q9CYC6 (/ISO)
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