The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 87: Transcriptional adapter 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
23 A0A024R0Y4 (/IPI) A0A024R0Y4 (/IPI) A0A024R0Y4 (/IPI) A0A024R0Y4 (/IPI) A0A024R0Y4 (/IPI) A0A024R0Y4 (/IPI) A0A024R0Y4 (/IPI) A0A024R0Y4 (/IPI) A0A024R0Y4 (/IPI) A0A024R0Y4 (/IPI)
(13 more)
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
9 Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q9ATB4 (/IDA)
Phosphatidylserine binding GO:0001786
Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
8 Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA)
Phosphatidylserine binding GO:0001786
Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
8 Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
8 Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 O75478 (/ISA) O75478 (/ISA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 O13719 (/ISM) O74443 (/ISM)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
2 Q59WH0 (/IDA) Q59WH0 (/IDA)
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
1 Q9P7J7 (/ISO)

There are 46 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
11 Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q59WH0 (/IMP) Q59WH0 (/IMP)
(1 more)
Chromatin silencing at rDNA GO:0000183
Repression of transcription of ribosomal DNA by altering the structure of chromatin.
8 Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP)
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
8 Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA)
Chromatin silencing at telomere GO:0006348
Repression of transcription of telomeric DNA by altering the structure of chromatin.
8 Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP)
Positive regulation of histone acetylation GO:0035066
Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein.
8 Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP)
Replication-born double-strand break repair via sister chromatid exchange GO:1990414
The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks.
8 Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP) Q02336 (/IMP)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
4 Q59WH0 (/IMP) Q59WH0 (/IMP) Q6FMQ2 (/IMP) Q6FMQ2 (/IMP)
Ascospore formation GO:0030437
The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota).
4 Q99326 (/HMP) Q99326 (/HMP) Q99326 (/HMP) Q99326 (/HMP)
Fungal-type cell wall organization GO:0031505
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall.
4 Q59WH0 (/IMP) Q59WH0 (/IMP) Q6FMQ2 (/IMP) Q6FMQ2 (/IMP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
4 Q59WH0 (/IMP) Q59WH0 (/IMP) Q6FMQ2 (/IMP) Q6FMQ2 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 Q99326 (/HMP) Q99326 (/HMP) Q99326 (/HMP) Q99326 (/HMP)
Histone acetylation GO:0016573
The modification of a histone by the addition of an acetyl group.
3 Q59WH0 (/IMP) Q59WH0 (/IMP) Q9P7J7 (/IMP)
Histone H3 acetylation GO:0043966
The modification of histone H3 by the addition of an acetyl group.
3 E1JIP2 (/IDA) O75478 (/IDA) O75478 (/IDA)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
2 O13719 (/IPI) O74443 (/IPI)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 O75478 (/TAS) O75478 (/TAS)
Positive regulation of cell-substrate adhesion GO:0010811
Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
2 Q59WH0 (/IMP) Q59WH0 (/IMP)
Histone acetylation GO:0016573
The modification of a histone by the addition of an acetyl group.
2 C8V3C2 (/IDA) E1JIP2 (/IDA)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
2 Q59WH0 (/IMP) Q59WH0 (/IMP)
Cell adhesion involved in single-species biofilm formation GO:0043709
The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
2 Q59WH0 (/IMP) Q59WH0 (/IMP)
Development of symbiont in host GO:0044114
The progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction.
2 Q59WH0 (/IMP) Q59WH0 (/IMP)
Filamentous growth of a population of unicellular organisms GO:0044182
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape.
2 Q59WH0 (/IMP) Q59WH0 (/IMP)
Positive regulation of cell adhesion involved in single-species biofilm formation GO:1900189
Any process that activates or increases the frequency, rate or extent of cell adhesion involved in single-species biofilm formation.
2 Q59WH0 (/IMP) Q59WH0 (/IMP)
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
1 Q8CHV6 (/IMP)
Regulation of protein phosphorylation GO:0001932
Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
1 Q8CHV6 (/IMP)
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
1 Q9P7J7 (/IMP)
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
1 Q54VX6 (/ISS)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
1 Q9P7J7 (/IC)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
1 E1JIP2 (/IDA)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q9P7J7 (/EXP)
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
1 F4JFM6 (/IMP)
Cold acclimation GO:0009631
Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures.
1 Q9ATB4 (/IMP)
Response to auxin GO:0009733
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus.
1 Q9ATB4 (/IMP)
Response to cytokinin GO:0009735
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.
1 Q9ATB4 (/IMP)
Regulation of reciprocal meiotic recombination GO:0010520
Any process that modulates the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate.
1 Q9P7J7 (/IMP)
Histone acetylation GO:0016573
The modification of a histone by the addition of an acetyl group.
1 Q54VX6 (/ISS)
Histone deacetylation GO:0016575
The modification of histones by removal of acetyl groups.
1 O74443 (/IC)
Nucleosome positioning GO:0016584
Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another.
1 C8V3C2 (/IDA)
Regulation of histone deacetylation GO:0031063
Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones.
1 Q8CHV6 (/IGI)
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
1 Q8CHV6 (/IMP)
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
1 Q9ATB4 (/IMP)
MRNA transcription by RNA polymerase II GO:0042789
The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter.
1 Q7KSD8 (/IDA)
Histone H3 acetylation GO:0043966
The modification of histone H3 by the addition of an acetyl group.
1 Q8CHV6 (/ISO)
Histone H4 acetylation GO:0043967
The modification of histone H4 by the addition of an acetyl group.
1 E1JIP2 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 O74443 (/ISO)
Cellular response to osmotic stress GO:0071470
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
1 Q9P7J7 (/IMP)
Regulation of tubulin deacetylation GO:0090043
Any process that modulates the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid.
1 Q8CHV6 (/IGI)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
SAGA complex GO:0000124
A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery; the ubiquitin specifc protease Ubp-8.
10 C8V3C2 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q9P7J7 (/IDA)
Ada2/Gcn5/Ada3 transcription activator complex GO:0005671
A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues.
10 E1JIP2 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q8CHV6 (/IDA)
SLIK (SAGA-like) complex GO:0046695
A SAGA-type histone acetyltransferase complex that contains Rtg2 and a smaller form of Spt7 than the fungal SAGA complex, and lacks Spt8. The complex is involved in the yeast retrograde response pathway, which is important for gene expression changes during mitochondrial dysfunction.
8 Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA) Q02336 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 E1JIP2 (/IDA) Q7KSD8 (/IDA) Q8CHV6 (/IDA) Q9ATB4 (/IDA)
PCAF complex GO:0000125
A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs.
2 O75478 (/IDA) O75478 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O74443 (/HDA) Q9P7J7 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O75478 (/TAS) O75478 (/TAS)
Rpd3S complex GO:0032221
A eukaryotically conserved histone deacetylase complex which deacetylates histones preferentially in promoter regions. Composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3 in Saccharomyces; homologs thereof in other species).
2 O13719 (/IDA) O74443 (/IDA)
Rpd3L-Expanded complex GO:0070210
A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins.
2 O13719 (/IDA) O74443 (/IDA)
Clr6 histone deacetylase complex I'' GO:1990483
A histone deacetylase complex involved in chromatin organization. In Schizosaccharomyces pombe this complex consists of Clr6, Nts1, Mug165, and Png3.
2 O13719 (/IPI) O74443 (/IPI)
SAGA complex GO:0000124
A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery; the ubiquitin specifc protease Ubp-8.
1 Q9P7J7 (/IPI)
PCAF complex GO:0000125
A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs.
1 Q8CHV6 (/ISO)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 Q9P7J7 (/NAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q54VX6 (/IC)
Transcriptionally active chromatin GO:0035327
The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed.
1 E1JIP2 (/IDA)
Mitotic spindle GO:0072686
A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
1 Q8CHV6 (/IDA)
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