The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 82: forkhead box protein B2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
42 B0JZ54 (/ISS) C1K2Y2 (/ISS) C1K2Y2 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS)
(32 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
25 Q5VYV0 (/ISA) Q99853 (/ISA) Q99853 (/ISA) Q99853 (/ISA) Q99853 (/ISA) Q99853 (/ISA) Q99853 (/ISA) Q99853 (/ISA) Q99853 (/ISA) Q99853 (/ISA)
(15 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
24 Q99853 (/ISM) Q99853 (/ISM) Q99853 (/ISM) Q99853 (/ISM) Q99853 (/ISM) Q99853 (/ISM) Q99853 (/ISM) Q99853 (/ISM) Q99853 (/ISM) Q99853 (/ISM)
(14 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
24 Q99853 (/NAS) Q99853 (/NAS) Q99853 (/NAS) Q99853 (/NAS) Q99853 (/NAS) Q99853 (/NAS) Q99853 (/NAS) Q99853 (/NAS) Q99853 (/NAS) Q99853 (/NAS)
(14 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
24 Q99853 (/IPI) Q99853 (/IPI) Q99853 (/IPI) Q99853 (/IPI) Q99853 (/IPI) Q99853 (/IPI) Q99853 (/IPI) Q99853 (/IPI) Q99853 (/IPI) Q99853 (/IPI)
(14 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
3 O93529 (/NAS) O93529 (/NAS) Q8JIT6 (/NAS)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
3 O93529 (/NAS) O93529 (/NAS) Q8JIT6 (/NAS)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
2 P34683 (/IDA) Q64732 (/IDA)

There are 40 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
42 B0JZ54 (/ISS) C1K2Y2 (/ISS) C1K2Y2 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS)
(32 more)
Axon target recognition GO:0007412
The process in which an axon recognizes and binds to a set of cells with which it may form stable connections.
42 B0JZ54 (/ISS) C1K2Y2 (/ISS) C1K2Y2 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS)
(32 more)
Visual learning GO:0008542
Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.
42 B0JZ54 (/ISS) C1K2Y2 (/ISS) C1K2Y2 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS)
(32 more)
Mammillary body development GO:0021767
The progression of the mammillary body over time from its initial formation until its mature state. The mammillary body is a protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei.
42 B0JZ54 (/ISS) C1K2Y2 (/ISS) C1K2Y2 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS)
(32 more)
Hypothalamus cell migration GO:0021855
The directed movement of a cell into the hypothalamus region of the forebrain.
42 B0JZ54 (/ISS) C1K2Y2 (/ISS) C1K2Y2 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS)
(32 more)
Telencephalon cell migration GO:0022029
The orderly movement of a cell from one site to another at least one of which is located in the telencephalon.
42 B0JZ54 (/ISS) C1K2Y2 (/ISS) C1K2Y2 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS)
(32 more)
Midbrain development GO:0030901
The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).
42 B0JZ54 (/ISS) C1K2Y2 (/ISS) C1K2Y2 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS)
(32 more)
Floor plate development GO:0033504
The progression of the floor plate over time from its initial formation until its mature state.
42 B0JZ54 (/ISS) C1K2Y2 (/ISS) C1K2Y2 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS)
(32 more)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
42 B0JZ54 (/ISS) C1K2Y2 (/ISS) C1K2Y2 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS)
(32 more)
Mammillothalamic axonal tract development GO:0061374
The progression of the mammillothalamic axonal tract, from its formation to the mature structure. The mammillothalamic tract is the collection of axons that connects the two major subdivisions of the diencephalon (hypothalamus and thalamus) and closes the diencephalic circuit.
42 B0JZ54 (/ISS) C1K2Y2 (/ISS) C1K2Y2 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS)
(32 more)
Inferior colliculus development GO:0061379
The process whose specific outcome is the progression of the inferior colliculus over time, from its formation to the mature structure. The inferior colliculus (IC) (Latin, lower hill) is the principal midbrain nucleus of the auditory pathway and receives input from several more peripheral brainstem nuclei in the auditory pathway, as well as inputs from the auditory cortex. The inferior colliculus has three subdivisions: the central nucleus (CIC), a dorsal cortex (DCIC) by which it is surrounded, and an external cortex (ICX) which is located laterally.
42 B0JZ54 (/ISS) C1K2Y2 (/ISS) C1K2Y2 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS)
(32 more)
Cell migration in diencephalon GO:0061381
The orderly movement of a cell that will reside in the diencephalon.
42 B0JZ54 (/ISS) C1K2Y2 (/ISS) C1K2Y2 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS)
(32 more)
Lactation GO:0007595
The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
35 D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) E1B7H0 (/ISS) E1B7H0 (/ISS)
(25 more)
Epithelial cell differentiation involved in mammary gland alveolus development GO:0061030
The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland alveolus.
35 D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) E1B7H0 (/ISS) E1B7H0 (/ISS)
(25 more)
Mammary gland lobule development GO:0061377
The progression of the mammary gland lobule over time, from its formation to the mature structure. A mammary gland lobule is a small rounded projection of the mammary gland.
35 D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) E1B7H0 (/ISS) E1B7H0 (/ISS)
(25 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
3 O93529 (/NAS) O93529 (/NAS) Q8JIT6 (/NAS)
Ectoderm development GO:0007398
The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.
2 O93529 (/IEP) O93529 (/IEP)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
2 O73781 (/IEP) O93312 (/IEP)
Mammillary body development GO:0021767
The progression of the mammillary body over time from its initial formation until its mature state. The mammillary body is a protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei.
2 O73779 (/IMP) Q64732 (/IMP)
Neurogenesis GO:0022008
Generation of cells within the nervous system.
2 O93529 (/IEP) O93529 (/IEP)
Urogenital system development GO:0001655
The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure.
1 Q64732 (/IEP)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
1 Q64732 (/IMP)
Axon target recognition GO:0007412
The process in which an axon recognizes and binds to a set of cells with which it may form stable connections.
1 Q64732 (/IMP)
Lactation GO:0007595
The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
1 Q64732 (/IMP)
Visual learning GO:0008542
Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.
1 Q64732 (/IMP)
Spinal cord development GO:0021510
The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues.
1 Q64732 (/IEP)
Mammillary body development GO:0021767
The progression of the mammillary body over time from its initial formation until its mature state. The mammillary body is a protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei.
1 Q64732 (/IEP)
Thalamus development GO:0021794
The process in which the thalamus changes over time, from its initial formation to its mature state.
1 Q64732 (/IEP)
Hypothalamus cell migration GO:0021855
The directed movement of a cell into the hypothalamus region of the forebrain.
1 Q64732 (/IMP)
Telencephalon cell migration GO:0022029
The orderly movement of a cell from one site to another at least one of which is located in the telencephalon.
1 Q64732 (/IMP)
Midbrain development GO:0030901
The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).
1 Q64732 (/IMP)
Floor plate development GO:0033504
The progression of the floor plate over time from its initial formation until its mature state.
1 Q64732 (/IMP)
Vulval development GO:0040025
The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.
1 P34683 (/IGI)
Vulval development GO:0040025
The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.
1 P34683 (/IMP)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
1 Q64732 (/IMP)
Epithelial cell differentiation involved in mammary gland alveolus development GO:0061030
The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland alveolus.
1 Q64732 (/IMP)
Mammillothalamic axonal tract development GO:0061374
The progression of the mammillothalamic axonal tract, from its formation to the mature structure. The mammillothalamic tract is the collection of axons that connects the two major subdivisions of the diencephalon (hypothalamus and thalamus) and closes the diencephalic circuit.
1 Q64732 (/IMP)
Mammary gland lobule development GO:0061377
The progression of the mammary gland lobule over time, from its formation to the mature structure. A mammary gland lobule is a small rounded projection of the mammary gland.
1 Q64732 (/IMP)
Inferior colliculus development GO:0061379
The process whose specific outcome is the progression of the inferior colliculus over time, from its formation to the mature structure. The inferior colliculus (IC) (Latin, lower hill) is the principal midbrain nucleus of the auditory pathway and receives input from several more peripheral brainstem nuclei in the auditory pathway, as well as inputs from the auditory cortex. The inferior colliculus has three subdivisions: the central nucleus (CIC), a dorsal cortex (DCIC) by which it is surrounded, and an external cortex (ICX) which is located laterally.
1 Q64732 (/IMP)
Cell migration in diencephalon GO:0061381
The orderly movement of a cell that will reside in the diencephalon.
1 Q64732 (/IMP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
42 B0JZ54 (/ISS) C1K2Y2 (/ISS) C1K2Y2 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS) D2HLR1 (/ISS)
(32 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 O93529 (/NAS) O93529 (/NAS) Q8JIT6 (/NAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P34683 (/IDA) Q64732 (/IDA)
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