The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 68: RNA polymerase sigma factor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sigma factor activity GO:0016987
Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins.
17 P9WGG7 (/IDA) P9WGG7 (/IDA) P9WGG7 (/IDA) P9WGG7 (/IDA) P9WGG7 (/IDA) P9WGG7 (/IDA) P9WGG7 (/IDA) P9WGG7 (/IDA) P9WGG7 (/IDA) P9WGG7 (/IDA)
(7 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
12 P9WGG7 (/IDA) P9WGG7 (/IDA) P9WGG7 (/IDA) P9WGG7 (/IDA) P9WGG7 (/IDA) P9WGG7 (/IDA) P9WGG7 (/IDA) P9WGG7 (/IDA) P9WGG7 (/IDA) P9WGG7 (/IDA)
(2 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 P9WGH9 (/IPI) P9WGH9 (/IPI) P9WGH9 (/IPI) P9WGH9 (/IPI) P9WGH9 (/IPI) P9WGH9 (/IPI) P9WGH9 (/IPI) P9WGH9 (/IPI)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
20 P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP)
(10 more)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
12 P9WGG7 (/IMP) P9WGG7 (/IMP) P9WGG7 (/IMP) P9WGG7 (/IMP) P9WGG7 (/IMP) P9WGG7 (/IMP) P9WGG7 (/IMP) P9WGG7 (/IMP) P9WGG7 (/IMP) P9WGG7 (/IMP)
(2 more)
Response to xenobiotic stimulus GO:0009410
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.
12 P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP)
(2 more)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
12 P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP)
(2 more)
Growth of symbiont in host cell GO:0044119
The increase in size or mass of symbiont, occurring in its host's cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.
12 P9WGG7 (/IMP) P9WGG7 (/IMP) P9WGG7 (/IMP) P9WGG7 (/IMP) P9WGG7 (/IMP) P9WGG7 (/IMP) P9WGG7 (/IMP) P9WGG7 (/IMP) P9WGG7 (/IMP) P9WGG7 (/IMP)
(2 more)
Response to host immune response GO:0052572
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
12 P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP) P9WGG7 (/IEP)
(2 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
8 P9WGH9 (/IDA) P9WGH9 (/IDA) P9WGH9 (/IDA) P9WGH9 (/IDA) P9WGH9 (/IDA) P9WGH9 (/IDA) P9WGH9 (/IDA) P9WGH9 (/IDA)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
8 P9WGH9 (/IEP) P9WGH9 (/IEP) P9WGH9 (/IEP) P9WGH9 (/IEP) P9WGH9 (/IEP) P9WGH9 (/IEP) P9WGH9 (/IEP) P9WGH9 (/IEP)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
8 P9WGH9 (/IMP) P9WGH9 (/IMP) P9WGH9 (/IMP) P9WGH9 (/IMP) P9WGH9 (/IMP) P9WGH9 (/IMP) P9WGH9 (/IMP) P9WGH9 (/IMP)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
8 P9WGH9 (/IMP) P9WGH9 (/IMP) P9WGH9 (/IMP) P9WGH9 (/IMP) P9WGH9 (/IMP) P9WGH9 (/IMP) P9WGH9 (/IMP) P9WGH9 (/IMP)
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
8 P9WGH9 (/IMP) P9WGH9 (/IMP) P9WGH9 (/IMP) P9WGH9 (/IMP) P9WGH9 (/IMP) P9WGH9 (/IMP) P9WGH9 (/IMP) P9WGH9 (/IMP)
Response to nitrosative stress GO:0051409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.
8 P9WGH9 (/IMP) P9WGH9 (/IMP) P9WGH9 (/IMP) P9WGH9 (/IMP) P9WGH9 (/IMP) P9WGH9 (/IMP) P9WGH9 (/IMP) P9WGH9 (/IMP)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
5 Q7AKG9 (/IDA) Q7AKG9 (/IDA) Q7AKG9 (/IDA) Q7AKG9 (/IDA) Q7AKG9 (/IDA)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
8 P9WGH9 (/HDA) P9WGH9 (/HDA) P9WGH9 (/HDA) P9WGH9 (/HDA) P9WGH9 (/HDA) P9WGH9 (/HDA) P9WGH9 (/HDA) P9WGH9 (/HDA)
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