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CATH Superfamily 1.10.10.10

Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: cAMP-activated global transcriptional regulator CR...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 23 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 325 P0A2T6 (/IMP) P0A2T6 (/IMP) P0A2T6 (/IMP) P0A2T6 (/IMP) P0A2T6 (/IMP) P0A2T6 (/IMP) P0A2T6 (/IMP) P0A2T6 (/IMP) P0A2T6 (/IMP) P0A2T6 (/IMP)
(315 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
 325 P0A2T6 (/IMP) P0A2T6 (/IMP) P0A2T6 (/IMP) P0A2T6 (/IMP) P0A2T6 (/IMP) P0A2T6 (/IMP) P0A2T6 (/IMP) P0A2T6 (/IMP) P0A2T6 (/IMP) P0A2T6 (/IMP)
(315 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
 217 P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI)
(207 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 205 P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI)
(195 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
 205 P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI)
(195 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
 205 P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA)
(195 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
 84 B0RN01 (/ISS) B0RN01 (/ISS) B0RN01 (/ISS) B0RN01 (/ISS) B0RN01 (/ISS) B2SL05 (/ISS) B2SL05 (/ISS) B2SL05 (/ISS) B2SL05 (/ISS) Q2NYD9 (/ISS)
(74 more)
Protein dimerization activity GO:0046983
The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
 74 B0RN01 (/ISS) B0RN01 (/ISS) B0RN01 (/ISS) B0RN01 (/ISS) B0RN01 (/ISS) B2SL05 (/ISS) B2SL05 (/ISS) B2SL05 (/ISS) B2SL05 (/ISS) Q2NYD9 (/ISS)
(64 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 67 A0KST7 (/IDA) A0KST7 (/IDA) A0KST7 (/IDA) A0KST7 (/IDA) A0KST7 (/IDA) A0KST7 (/IDA) A0KST7 (/IDA) A0KST7 (/IDA) A0KST7 (/IDA) A0KST7 (/IDA)
(57 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
 65 A0KST7 (/IDA) A0KST7 (/IDA) A0KST7 (/IDA) A0KST7 (/IDA) A0KST7 (/IDA) A0KST7 (/IDA) A0KST7 (/IDA) A0KST7 (/IDA) A0KST7 (/IDA) A0KST7 (/IDA)
(55 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
 43 B0RN01 (/ISS) B0RN01 (/ISS) B0RN01 (/ISS) B0RN01 (/ISS) B0RN01 (/ISS) B2SL05 (/ISS) B2SL05 (/ISS) B2SL05 (/ISS) B2SL05 (/ISS) Q2NYD9 (/ISS)
(33 more)
Cyclic-di-GMP binding GO:0035438
Interacting selectively and non-covalently with cyclic-di-GMP, cyclic dimeric guanosine monophosphate.
 43 B0RN01 (/ISS) B0RN01 (/ISS) B0RN01 (/ISS) B0RN01 (/ISS) B0RN01 (/ISS) B2SL05 (/ISS) B2SL05 (/ISS) B2SL05 (/ISS) B2SL05 (/ISS) Q2NYD9 (/ISS)
(33 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
 36 P22260 (/IDA) P22260 (/IDA) P22260 (/IDA) P22260 (/IDA) P22260 (/IDA) Q4UZF6 (/IDA) Q4UZF6 (/IDA) Q4UZF6 (/IDA) Q4UZF6 (/IDA) Q4UZF6 (/IDA)
(26 more)
Cyclic-di-GMP binding GO:0035438
Interacting selectively and non-covalently with cyclic-di-GMP, cyclic dimeric guanosine monophosphate.
 36 P22260 (/IDA) P22260 (/IDA) P22260 (/IDA) P22260 (/IDA) P22260 (/IDA) Q4UZF6 (/IDA) Q4UZF6 (/IDA) Q4UZF6 (/IDA) Q4UZF6 (/IDA) Q4UZF6 (/IDA)
(26 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 27 O34015 (/IPI) O34015 (/IPI) P55222 (/IPI) P55222 (/IPI) P55222 (/IPI) P55222 (/IPI) P55222 (/IPI) P55222 (/IPI) P55222 (/IPI) P55222 (/IPI)
(17 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
 25 P55222 (/IPI) P55222 (/IPI) P55222 (/IPI) P55222 (/IPI) P55222 (/IPI) P55222 (/IPI) P55222 (/IPI) P55222 (/IPI) P55222 (/IPI) P55222 (/IPI)
(15 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
 21 O34015 (/IDA) O34015 (/IDA) P55222 (/IDA) P55222 (/IDA) P55222 (/IDA) P55222 (/IDA) P55222 (/IDA) P55222 (/IDA) P55222 (/IDA) P55222 (/IDA)
(11 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
 19 P55222 (/IMP) P55222 (/IMP) P55222 (/IMP) P55222 (/IMP) P55222 (/IMP) P55222 (/IMP) P55222 (/IMP) P55222 (/IMP) P55222 (/IMP) P55222 (/IMP)
(9 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
 14 O34015 (/IPI) O34015 (/IPI) P55222 (/IPI) P55222 (/IPI) P55222 (/IPI) P55222 (/IPI) P55222 (/IPI) P55222 (/IPI) P55222 (/IPI) P55222 (/IPI)
(4 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
 10 P22260 (/IMP) P22260 (/IMP) P22260 (/IMP) P22260 (/IMP) P22260 (/IMP) Q4UZF6 (/IMP) Q4UZF6 (/IMP) Q4UZF6 (/IMP) Q4UZF6 (/IMP) Q4UZF6 (/IMP)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 6 Q88QR4 (/EXP) Q88QR4 (/EXP) Q88QR4 (/EXP) Q88QR4 (/EXP) Q88QR4 (/EXP) Q88QR4 (/EXP)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
 6 Q88QR4 (/EXP) Q88QR4 (/EXP) Q88QR4 (/EXP) Q88QR4 (/EXP) Q88QR4 (/EXP) Q88QR4 (/EXP)
Protein dimerization activity GO:0046983
The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
 5 P22260 (/IDA) P22260 (/IDA) P22260 (/IDA) P22260 (/IDA) P22260 (/IDA)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
 336 P0A2T6 (/IEP) P0A2T6 (/IEP) P0A2T6 (/IEP) P0A2T6 (/IEP) P0A2T6 (/IEP) P0A2T6 (/IEP) P0A2T6 (/IEP) P0A2T6 (/IEP) P0A2T6 (/IEP) P0A2T6 (/IEP)
(326 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
 237 A0KST7 (/EXP) A0KST7 (/EXP) A0KST7 (/EXP) A0KST7 (/EXP) A0KST7 (/EXP) A0KST7 (/EXP) A0KST7 (/EXP) A0KST7 (/EXP) A0KST7 (/EXP) A0KST7 (/EXP)
(227 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
 224 P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA)
(214 more)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
 217 P0ACJ8 (/IMP) P0ACJ8 (/IMP) P0ACJ8 (/IMP) P0ACJ8 (/IMP) P0ACJ8 (/IMP) P0ACJ8 (/IMP) P0ACJ8 (/IMP) P0ACJ8 (/IMP) P0ACJ8 (/IMP) P0ACJ8 (/IMP)
(207 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 212 P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA)
(202 more)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
 205 P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA)
(195 more)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
 205 P0ACJ8 (/IEP) P0ACJ8 (/IEP) P0ACJ8 (/IEP) P0ACJ8 (/IEP) P0ACJ8 (/IEP) P0ACJ8 (/IEP) P0ACJ8 (/IEP) P0ACJ8 (/IEP) P0ACJ8 (/IEP) P0ACJ8 (/IEP)
(195 more)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
 205 P0ACJ8 (/ISS) P0ACJ8 (/ISS) P0ACJ8 (/ISS) P0ACJ8 (/ISS) P0ACJ8 (/ISS) P0ACJ8 (/ISS) P0ACJ8 (/ISS) P0ACJ8 (/ISS) P0ACJ8 (/ISS) P0ACJ8 (/ISS)
(195 more)
Carbon catabolite repression of transcription GO:0045013
A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances.
 205 P0ACJ8 (/IMP) P0ACJ8 (/IMP) P0ACJ8 (/IMP) P0ACJ8 (/IMP) P0ACJ8 (/IMP) P0ACJ8 (/IMP) P0ACJ8 (/IMP) P0ACJ8 (/IMP) P0ACJ8 (/IMP) P0ACJ8 (/IMP)
(195 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 205 P0ACJ8 (/EXP) P0ACJ8 (/EXP) P0ACJ8 (/EXP) P0ACJ8 (/EXP) P0ACJ8 (/EXP) P0ACJ8 (/EXP) P0ACJ8 (/EXP) P0ACJ8 (/EXP) P0ACJ8 (/EXP) P0ACJ8 (/EXP)
(195 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
 84 B0RN01 (/ISS) B0RN01 (/ISS) B0RN01 (/ISS) B0RN01 (/ISS) B0RN01 (/ISS) B2SL05 (/ISS) B2SL05 (/ISS) B2SL05 (/ISS) B2SL05 (/ISS) Q2NYD9 (/ISS)
(74 more)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
 12 P55222 (/IMP) P55222 (/IMP) P55222 (/IMP) P55222 (/IMP) P55222 (/IMP) P55222 (/IMP) P55222 (/IMP) P55222 (/IMP) P55222 (/IMP) P55222 (/IMP)
(2 more)
Positive regulation of multi-organism process GO:0043902
Any process that activates or increases the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species.
 12 P55222 (/IMP) P55222 (/IMP) P55222 (/IMP) P55222 (/IMP) P55222 (/IMP) P55222 (/IMP) P55222 (/IMP) P55222 (/IMP) P55222 (/IMP) P55222 (/IMP)
(2 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
 10 P22260 (/IMP) P22260 (/IMP) P22260 (/IMP) P22260 (/IMP) P22260 (/IMP) Q4UZF6 (/IMP) Q4UZF6 (/IMP) Q4UZF6 (/IMP) Q4UZF6 (/IMP) Q4UZF6 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 7 Q7M7I9 (/IEP) Q7M7I9 (/IEP) Q7M7I9 (/IEP) Q7M7I9 (/IEP) Q7M7I9 (/IEP) Q7M7I9 (/IEP) Q7M7I9 (/IEP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 325 P0A2T6 (/IMP) P0A2T6 (/IMP) P0A2T6 (/IMP) P0A2T6 (/IMP) P0A2T6 (/IMP) P0A2T6 (/IMP) P0A2T6 (/IMP) P0A2T6 (/IMP) P0A2T6 (/IMP) P0A2T6 (/IMP)
(315 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 272 A0KST7 (/IDA) A0KST7 (/IDA) A0KST7 (/IDA) A0KST7 (/IDA) A0KST7 (/IDA) A0KST7 (/IDA) A0KST7 (/IDA) A0KST7 (/IDA) A0KST7 (/IDA) A0KST7 (/IDA)
(262 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 232 O34015 (/IPI) O34015 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI) P0ACJ8 (/IPI)
(222 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 205 P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA) P0ACJ8 (/IDA)
(195 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 6 Q88QR4 (/EXP) Q88QR4 (/EXP) Q88QR4 (/EXP) Q88QR4 (/EXP) Q88QR4 (/EXP) Q88QR4 (/EXP)
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