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CATH Superfamily 1.10.10.10

Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 51: Fur family transcriptional regulator

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
 39 P54574 (/IDA) P54574 (/IDA) P54574 (/IDA) P54574 (/IDA) P54574 (/IDA) P54574 (/IDA) P54574 (/IDA) P54574 (/IDA) P54574 (/IDA) P54574 (/IDA)
(29 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 31 A0A0H3C2M1 (/IDA) A0A0H3C2M1 (/IDA) A0A0H3C2M1 (/IDA) A0A0H3C2M1 (/IDA) H7C6Q1 (/IDA) H7C6Q1 (/IDA) H7C6Q1 (/IDA) H7C6Q1 (/IDA) P54574 (/IDA) P54574 (/IDA)
(21 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 31 A0A0H3C2M1 (/IPI) A0A0H3C2M1 (/IPI) A0A0H3C2M1 (/IPI) A0A0H3C2M1 (/IPI) H7C6Q1 (/IPI) H7C6Q1 (/IPI) H7C6Q1 (/IPI) H7C6Q1 (/IPI) P54574 (/IPI) P54574 (/IPI)
(21 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
 31 A0A0H3C2M1 (/IDA) A0A0H3C2M1 (/IDA) A0A0H3C2M1 (/IDA) A0A0H3C2M1 (/IDA) H7C6Q1 (/IDA) H7C6Q1 (/IDA) H7C6Q1 (/IDA) H7C6Q1 (/IDA) P54574 (/IDA) P54574 (/IDA)
(21 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
 31 A0A0H3C2M1 (/IPI) A0A0H3C2M1 (/IPI) A0A0H3C2M1 (/IPI) A0A0H3C2M1 (/IPI) H7C6Q1 (/IPI) H7C6Q1 (/IPI) H7C6Q1 (/IPI) H7C6Q1 (/IPI) P54574 (/IPI) P54574 (/IPI)
(21 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
 22 Q2FY73 (/IPI) Q2FY73 (/IPI) Q2FY73 (/IPI) Q2FY73 (/IPI) Q2FY73 (/IPI) Q2FY73 (/IPI) Q2FY73 (/IPI) Q2FY73 (/IPI) Q2FY73 (/IPI) Q2FY73 (/IPI)
(12 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 8 A0A0H3C2M1 (/IMP) A0A0H3C2M1 (/IMP) A0A0H3C2M1 (/IMP) A0A0H3C2M1 (/IMP) H7C6Q1 (/IMP) H7C6Q1 (/IMP) H7C6Q1 (/IMP) H7C6Q1 (/IMP)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
 4 A0A0H3C2M1 (/IDA) A0A0H3C2M1 (/IDA) A0A0H3C2M1 (/IDA) A0A0H3C2M1 (/IDA)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
 4 A0A0H3C2M1 (/IMP) A0A0H3C2M1 (/IMP) A0A0H3C2M1 (/IMP) A0A0H3C2M1 (/IMP)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
 4 A0A0H3C2M1 (/IPI) A0A0H3C2M1 (/IPI) A0A0H3C2M1 (/IPI) A0A0H3C2M1 (/IPI)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
 4 H7C6Q1 (/IMP) H7C6Q1 (/IMP) H7C6Q1 (/IMP) H7C6Q1 (/IMP)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
 2 Q97FU2 (/IMP) Q97FU2 (/IMP)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 27 H7C6Q1 (/EXP) H7C6Q1 (/EXP) H7C6Q1 (/EXP) H7C6Q1 (/EXP) P54574 (/EXP) P54574 (/EXP) P54574 (/EXP) P54574 (/EXP) P54574 (/EXP) P54574 (/EXP)
(17 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 27 H7C6Q1 (/IDA) H7C6Q1 (/IDA) H7C6Q1 (/IDA) H7C6Q1 (/IDA) P54574 (/IDA) P54574 (/IDA) P54574 (/IDA) P54574 (/IDA) P54574 (/IDA) P54574 (/IDA)
(17 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 19 P54574 (/IMP) P54574 (/IMP) P54574 (/IMP) P54574 (/IMP) P54574 (/IMP) P54574 (/IMP) P54574 (/IMP) P54574 (/IMP) P54574 (/IMP) P54574 (/IMP)
(9 more)
Cellular response to iron ion GO:0071281
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.
 12 A0A0H3GII4 (/IEP) A0A0H3GII4 (/IEP) A0A0H3GII4 (/IEP) A0A0H3GII4 (/IEP) A0A0H3GII4 (/IEP) A0A0H3GII4 (/IEP) Q8Y5U9 (/IEP) Q8Y5U9 (/IEP) Q8Y5U9 (/IEP) Q8Y5U9 (/IEP)
(2 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 10 H7C6Q1 (/IEP) H7C6Q1 (/IEP) H7C6Q1 (/IEP) H7C6Q1 (/IEP) Q8Y5U9 (/IEP) Q8Y5U9 (/IEP) Q8Y5U9 (/IEP) Q8Y5U9 (/IEP) Q8Y5U9 (/IEP) Q8Y5U9 (/IEP)
Cellular response to iron ion GO:0071281
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.
 6 Q8Y5U9 (/EXP) Q8Y5U9 (/EXP) Q8Y5U9 (/EXP) Q8Y5U9 (/EXP) Q8Y5U9 (/EXP) Q8Y5U9 (/EXP)
Regulation of oxygen metabolic process GO:2000374
Any process that modulates the frequency, rate or extent of oxygen metabolic process.
 2 Q97FU2 (/IMP) Q97FU2 (/IMP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 53 A0A0H3C2M1 (/IDA) A0A0H3C2M1 (/IDA) A0A0H3C2M1 (/IDA) A0A0H3C2M1 (/IDA) H7C6Q1 (/IDA) H7C6Q1 (/IDA) H7C6Q1 (/IDA) H7C6Q1 (/IDA) P54574 (/IDA) P54574 (/IDA)
(43 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 53 A0A0H3C2M1 (/IPI) A0A0H3C2M1 (/IPI) A0A0H3C2M1 (/IPI) A0A0H3C2M1 (/IPI) H7C6Q1 (/IPI) H7C6Q1 (/IPI) H7C6Q1 (/IPI) H7C6Q1 (/IPI) P54574 (/IPI) P54574 (/IPI)
(43 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 8 A0A0H3C2M1 (/IMP) A0A0H3C2M1 (/IMP) A0A0H3C2M1 (/IMP) A0A0H3C2M1 (/IMP) H7C6Q1 (/IMP) H7C6Q1 (/IMP) H7C6Q1 (/IMP) H7C6Q1 (/IMP)