The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: Two-component system response regulator

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
151 P0ACZ8 (/IDA) P0ACZ8 (/IDA) P0ACZ8 (/IDA) P0ACZ8 (/IDA) P0ACZ8 (/IDA) P0ACZ8 (/IDA) P0ACZ8 (/IDA) P0ACZ8 (/IDA) P0ACZ8 (/IDA) P0ACZ8 (/IDA)
(141 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
136 A5U0E5 (/IPI) P0ACZ8 (/IPI) P0ACZ8 (/IPI) P0ACZ8 (/IPI) P0ACZ8 (/IPI) P0ACZ8 (/IPI) P0ACZ8 (/IPI) P0ACZ8 (/IPI) P0ACZ8 (/IPI) P0ACZ8 (/IPI)
(126 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
68 Q1J8D4 (/IDA) Q1J8D4 (/IDA) Q1J8D4 (/IDA) Q1J8D4 (/IDA) Q1J8D4 (/IDA) Q1J8D4 (/IDA) Q1J8D4 (/IDA) Q1J8D4 (/IDA) Q1J8D4 (/IDA) Q1J8D4 (/IDA)
(58 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
68 Q1J8D4 (/IPI) Q1J8D4 (/IPI) Q1J8D4 (/IPI) Q1J8D4 (/IPI) Q1J8D4 (/IPI) Q1J8D4 (/IPI) Q1J8D4 (/IPI) Q1J8D4 (/IPI) Q1J8D4 (/IPI) Q1J8D4 (/IPI)
(58 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
60 Q1J8D4 (/IMP) Q1J8D4 (/IMP) Q1J8D4 (/IMP) Q1J8D4 (/IMP) Q1J8D4 (/IMP) Q1J8D4 (/IMP) Q1J8D4 (/IMP) Q1J8D4 (/IMP) Q1J8D4 (/IMP) Q1J8D4 (/IMP)
(50 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
56 Q87Z28 (/IDA) Q87Z28 (/IDA) Q87Z28 (/IDA) Q87Z28 (/IDA) Q87Z28 (/IDA) Q87Z28 (/IDA) Q87Z28 (/IDA) Q87Z28 (/IDA) Q87Z28 (/IDA) Q87Z28 (/IDA)
(46 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
48 Q87Z28 (/IMP) Q87Z28 (/IMP) Q87Z28 (/IMP) Q87Z28 (/IMP) Q87Z28 (/IMP) Q87Z28 (/IMP) Q87Z28 (/IMP) Q87Z28 (/IMP) Q87Z28 (/IMP) Q87Z28 (/IMP)
(38 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
48 Q87Z28 (/IPI) Q87Z28 (/IPI) Q87Z28 (/IPI) Q87Z28 (/IPI) Q87Z28 (/IPI) Q87Z28 (/IPI) Q87Z28 (/IPI) Q87Z28 (/IPI) Q87Z28 (/IPI) Q87Z28 (/IPI)
(38 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
20 Q1J8D4 (/IDA) Q1J8D4 (/IDA) Q1J8D4 (/IDA) Q1J8D4 (/IDA) Q1J8D4 (/IDA) Q1J8D4 (/IDA) Q1J8D4 (/IDA) Q1J8D4 (/IDA) Q1J8D4 (/IDA) Q1J8D4 (/IDA)
(10 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
20 Q1J8D4 (/IPI) Q1J8D4 (/IPI) Q1J8D4 (/IPI) Q1J8D4 (/IPI) Q1J8D4 (/IPI) Q1J8D4 (/IPI) Q1J8D4 (/IPI) Q1J8D4 (/IPI) Q1J8D4 (/IPI) Q1J8D4 (/IPI)
(10 more)
Phosphorelay response regulator activity GO:0000156
Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
14 Q748Q5 (/ISS) Q748Q5 (/ISS) Q9KRK2 (/ISS) Q9KRK2 (/ISS) Q9KRK2 (/ISS) Q9KRK2 (/ISS) Q9KRK2 (/ISS) Q9KRK2 (/ISS) Q9KRK2 (/ISS) Q9KRK2 (/ISS)
(4 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
13 O69730 (/IPI) O69730 (/IPI) O69730 (/IPI) O69730 (/IPI) O69730 (/IPI) O69730 (/IPI) O69730 (/IPI) O69730 (/IPI) O69730 (/IPI) O69730 (/IPI)
(3 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
12 Q1J8D4 (/IMP) Q1J8D4 (/IMP) Q1J8D4 (/IMP) Q1J8D4 (/IMP) Q1J8D4 (/IMP) Q1J8D4 (/IMP) Q1J8D4 (/IMP) Q1J8D4 (/IMP) Q1J8D4 (/IMP) Q1J8D4 (/IMP)
(2 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
3 P76340 (/IDA) P76340 (/IDA) P76340 (/IDA)
Phosphorelay response regulator activity GO:0000156
Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
2 P30843 (/IDA) P30843 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 Q748Q5 (/ISS) Q748Q5 (/ISS)

There are 32 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphorelay signal transduction system GO:0000160
A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
147 P0ACZ8 (/IDA) P0ACZ8 (/IDA) P0ACZ8 (/IDA) P0ACZ8 (/IDA) P0ACZ8 (/IDA) P0ACZ8 (/IDA) P0ACZ8 (/IDA) P0ACZ8 (/IDA) P0ACZ8 (/IDA) P0ACZ8 (/IDA)
(137 more)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
142 P0ACZ8 (/IMP) P0ACZ8 (/IMP) P0ACZ8 (/IMP) P0ACZ8 (/IMP) P0ACZ8 (/IMP) P0ACZ8 (/IMP) P0ACZ8 (/IMP) P0ACZ8 (/IMP) P0ACZ8 (/IMP) P0ACZ8 (/IMP)
(132 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
137 P0ACZ8 (/IMP) P0ACZ8 (/IMP) P0ACZ8 (/IMP) P0ACZ8 (/IMP) P0ACZ8 (/IMP) P0ACZ8 (/IMP) P0ACZ8 (/IMP) P0ACZ8 (/IMP) P0ACZ8 (/IMP) P0ACZ8 (/IMP)
(127 more)
Response to copper ion GO:0046688
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
135 P0ACZ8 (/IDA) P0ACZ8 (/IDA) P0ACZ8 (/IDA) P0ACZ8 (/IDA) P0ACZ8 (/IDA) P0ACZ8 (/IDA) P0ACZ8 (/IDA) P0ACZ8 (/IDA) P0ACZ8 (/IDA) P0ACZ8 (/IDA)
(125 more)
Response to copper ion GO:0046688
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
135 P0ACZ8 (/IMP) P0ACZ8 (/IMP) P0ACZ8 (/IMP) P0ACZ8 (/IMP) P0ACZ8 (/IMP) P0ACZ8 (/IMP) P0ACZ8 (/IMP) P0ACZ8 (/IMP) P0ACZ8 (/IMP) P0ACZ8 (/IMP)
(125 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
32 P71814 (/IDA) P71814 (/IDA) P71814 (/IDA) P71814 (/IDA) P71814 (/IDA) P71814 (/IDA) P71814 (/IDA) P76340 (/IDA) P76340 (/IDA) P76340 (/IDA)
(22 more)
Positive regulation of transporter activity GO:0032411
Any process that activates or increases the activity of a transporter.
26 G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP)
(16 more)
Positive regulation of multi-organism process GO:0043902
Any process that activates or increases the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species.
26 G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP)
(16 more)
Positive regulation of proteolysis GO:0045862
Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
26 G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP)
(16 more)
Positive regulation of single-species biofilm formation on inanimate substrate GO:1900233
Any process that activates or increases the frequency, rate or extent of single-species biofilm formation on inanimate substrate.
26 G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP)
(16 more)
Negative regulation of secondary metabolite biosynthetic process GO:1900377
Any process that stops, prevents or reduces the frequency, rate or extent of secondary metabolite biosynthetic process.
26 G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP) G3XD16 (/IMP)
(16 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
23 P71814 (/IDA) P71814 (/IDA) P71814 (/IDA) P71814 (/IDA) P71814 (/IDA) P71814 (/IDA) P71814 (/IDA) P76340 (/IDA) P76340 (/IDA) P76340 (/IDA)
(13 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
13 P76340 (/IEP) P76340 (/IEP) P76340 (/IEP) Q1J8D4 (/IEP) Q1J8D4 (/IEP) Q1J8D4 (/IEP) Q1J8D4 (/IEP) Q1J8D4 (/IEP) Q1J8D4 (/IEP) Q1J8D4 (/IEP)
(3 more)
Phosphorelay signal transduction system GO:0000160
A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
12 Q9KRK2 (/ISS) Q9KRK2 (/ISS) Q9KRK2 (/ISS) Q9KRK2 (/ISS) Q9KRK2 (/ISS) Q9KRK2 (/ISS) Q9KRK2 (/ISS) Q9KRK2 (/ISS) Q9KRK2 (/ISS) Q9KRK2 (/ISS)
(2 more)
Cellular response to iron ion starvation GO:0010106
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions.
10 O69730 (/IEP) O69730 (/IEP) O69730 (/IEP) O69730 (/IEP) O69730 (/IEP) O69730 (/IEP) O69730 (/IEP) O69730 (/IEP) O69730 (/IEP) O69730 (/IEP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
10 Q1J8D4 (/EXP) Q1J8D4 (/EXP) Q1J8D4 (/EXP) Q1J8D4 (/EXP) Q1J8D4 (/EXP) Q1J8D4 (/EXP) Q1J8D4 (/EXP) Q1J8D4 (/EXP) Q1J8D4 (/EXP) Q1J8D4 (/EXP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
10 B3VA60 (/IMP) Q50806 (/IMP) Q50806 (/IMP) Q50806 (/IMP) Q50806 (/IMP) Q50806 (/IMP) Q50806 (/IMP) Q50806 (/IMP) Q50806 (/IMP) Q50806 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
8 Q8DY68 (/EXP) Q8DY68 (/EXP) Q8DY68 (/EXP) Q8DY68 (/EXP) Q8DY68 (/EXP) Q8DY68 (/EXP) Q8DY68 (/EXP) Q8DY68 (/EXP)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
7 P71814 (/IMP) P71814 (/IMP) P71814 (/IMP) P71814 (/IMP) P71814 (/IMP) P71814 (/IMP) P71814 (/IMP)
Glycolipid biosynthetic process GO:0009247
The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide).
7 P71814 (/IMP) P71814 (/IMP) P71814 (/IMP) P71814 (/IMP) P71814 (/IMP) P71814 (/IMP) P71814 (/IMP)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
7 P71814 (/IMP) P71814 (/IMP) P71814 (/IMP) P71814 (/IMP) P71814 (/IMP) P71814 (/IMP) P71814 (/IMP)
Protein secretion by the type VII secretion system GO:0044315
The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type VII protein secretion system.
7 P71814 (/IMP) P71814 (/IMP) P71814 (/IMP) P71814 (/IMP) P71814 (/IMP) P71814 (/IMP) P71814 (/IMP)
Positive regulation of lipid biosynthetic process GO:0046889
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.
7 P71814 (/IMP) P71814 (/IMP) P71814 (/IMP) P71814 (/IMP) P71814 (/IMP) P71814 (/IMP) P71814 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
4 P9WGM9 (/IDA) P9WGM9 (/IDA) P9WGM9 (/IDA) P9WGM9 (/IDA)
Response to alkaline pH GO:0010446
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution.
4 P9WGM9 (/IEP) P9WGM9 (/IEP) P9WGM9 (/IEP) P9WGM9 (/IEP)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
3 P76340 (/ISS) P76340 (/ISS) P76340 (/ISS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
3 P76340 (/IEP) P76340 (/IEP) P76340 (/IEP)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
2 P52076 (/EXP) P52076 (/EXP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
2 Q748Q5 (/ISS) Q748Q5 (/ISS)
Response to metal ion GO:0010038
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.
2 P52076 (/IMP) P52076 (/IMP)
Response to iron(III) ion GO:0010041
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus.
2 P30843 (/IEP) P30843 (/IEP)
Response to iron(III) ion GO:0010041
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus.
2 P30843 (/IMP) P30843 (/IMP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
68 Q1J8D4 (/IDA) Q1J8D4 (/IDA) Q1J8D4 (/IDA) Q1J8D4 (/IDA) Q1J8D4 (/IDA) Q1J8D4 (/IDA) Q1J8D4 (/IDA) Q1J8D4 (/IDA) Q1J8D4 (/IDA) Q1J8D4 (/IDA)
(58 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
68 Q1J8D4 (/IPI) Q1J8D4 (/IPI) Q1J8D4 (/IPI) Q1J8D4 (/IPI) Q1J8D4 (/IPI) Q1J8D4 (/IPI) Q1J8D4 (/IPI) Q1J8D4 (/IPI) Q1J8D4 (/IPI) Q1J8D4 (/IPI)
(58 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
60 Q1J8D4 (/IMP) Q1J8D4 (/IMP) Q1J8D4 (/IMP) Q1J8D4 (/IMP) Q1J8D4 (/IMP) Q1J8D4 (/IMP) Q1J8D4 (/IMP) Q1J8D4 (/IMP) Q1J8D4 (/IMP) Q1J8D4 (/IMP)
(50 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
11 P71814 (/HDA) P71814 (/HDA) P71814 (/HDA) P71814 (/HDA) P71814 (/HDA) P71814 (/HDA) P71814 (/HDA) P9WGM9 (/HDA) P9WGM9 (/HDA) P9WGM9 (/HDA)
(1 more)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
4 P9WGM9 (/HDA) P9WGM9 (/HDA) P9WGM9 (/HDA) P9WGM9 (/HDA)