The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: RNA polymerase sigma factor SigA

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sigma factor activity GO:0016987
Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins.
36 A0A1J9WIU5 (/ISS) A0A1J9WIU5 (/ISS) A0A1J9WIU5 (/ISS) A0A1J9WIU5 (/ISS) A0A1J9WIU5 (/ISS) A0A1J9WIU5 (/ISS) A0A1J9WIU5 (/ISS) A0A1J9WIU5 (/ISS) A0A1J9WIU5 (/ISS) A0A1J9WIU5 (/ISS)
(26 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
27 P00579 (/IPI) P00579 (/IPI) P18183 (/IPI) P18183 (/IPI) P18183 (/IPI) P18183 (/IPI) P18183 (/IPI) P9WGI1 (/IPI) P9WGI1 (/IPI) P9WGI1 (/IPI)
(17 more)
Sigma factor activity GO:0016987
Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins.
17 P00579 (/IDA) P00579 (/IDA) P18183 (/IDA) P18183 (/IDA) P18183 (/IDA) P18183 (/IDA) P18183 (/IDA) P9WGI1 (/IDA) P9WGI1 (/IDA) P9WGI1 (/IDA)
(7 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
10 P9WGI1 (/IDA) P9WGI1 (/IDA) P9WGI1 (/IDA) P9WGI1 (/IDA) P9WGI1 (/IDA) P9WGI1 (/IDA) P9WGI1 (/IDA) P9WGI1 (/IDA) P9WGI1 (/IDA) P9WGI1 (/IDA)
Sigma factor activity GO:0016987
Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins.
10 P9WGI5 (/IGI) P9WGI5 (/IGI) P9WGI5 (/IGI) P9WGI5 (/IGI) P9WGI5 (/IGI) P9WGI5 (/IGI) P9WGI5 (/IGI) P9WGI5 (/IGI) P9WGI5 (/IGI) P9WGI5 (/IGI)
RNA polymerase core enzyme binding GO:0043175
Interacting selectively and non-covalently with an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme.
10 P9WGI5 (/IDA) P9WGI5 (/IDA) P9WGI5 (/IDA) P9WGI5 (/IDA) P9WGI5 (/IDA) P9WGI5 (/IDA) P9WGI5 (/IDA) P9WGI5 (/IDA) P9WGI5 (/IDA) P9WGI5 (/IDA)
Bacterial-type RNA polymerase holo enzyme binding GO:0001108
Interacting selectively and non-covalently with the basal transcription machinery which is composed of a bacterial-type RNA polymerase core enzyme and a sigma factor, the minimal set of factors required for formation of the preinitiation complex (PIC) by a bacterial-type RNA polymerase.
5 P18183 (/IDA) P18183 (/IDA) P18183 (/IDA) P18183 (/IDA) P18183 (/IDA)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-templated transcription, initiation GO:0006352
Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription.
36 A0A1J9WIU5 (/ISS) A0A1J9WIU5 (/ISS) A0A1J9WIU5 (/ISS) A0A1J9WIU5 (/ISS) A0A1J9WIU5 (/ISS) A0A1J9WIU5 (/ISS) A0A1J9WIU5 (/ISS) A0A1J9WIU5 (/ISS) A0A1J9WIU5 (/ISS) A0A1J9WIU5 (/ISS)
(26 more)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
12 P00579 (/IEP) P00579 (/IEP) P9WGI5 (/IEP) P9WGI5 (/IEP) P9WGI5 (/IEP) P9WGI5 (/IEP) P9WGI5 (/IEP) P9WGI5 (/IEP) P9WGI5 (/IEP) P9WGI5 (/IEP)
(2 more)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
10 P9WGI5 (/IEP) P9WGI5 (/IEP) P9WGI5 (/IEP) P9WGI5 (/IEP) P9WGI5 (/IEP) P9WGI5 (/IEP) P9WGI5 (/IEP) P9WGI5 (/IEP) P9WGI5 (/IEP) P9WGI5 (/IEP)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
10 P9WGI1 (/IMP) P9WGI1 (/IMP) P9WGI1 (/IMP) P9WGI1 (/IMP) P9WGI1 (/IMP) P9WGI1 (/IMP) P9WGI1 (/IMP) P9WGI1 (/IMP) P9WGI1 (/IMP) P9WGI1 (/IMP)
Response to xenobiotic stimulus GO:0009410
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.
10 P9WGI5 (/IEP) P9WGI5 (/IEP) P9WGI5 (/IEP) P9WGI5 (/IEP) P9WGI5 (/IEP) P9WGI5 (/IEP) P9WGI5 (/IEP) P9WGI5 (/IEP) P9WGI5 (/IEP) P9WGI5 (/IEP)
Response to water GO:0009415
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water.
10 P9WGI1 (/IEP) P9WGI1 (/IEP) P9WGI1 (/IEP) P9WGI1 (/IEP) P9WGI1 (/IEP) P9WGI1 (/IEP) P9WGI1 (/IEP) P9WGI1 (/IEP) P9WGI1 (/IEP) P9WGI1 (/IEP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
10 P9WGI5 (/IDA) P9WGI5 (/IDA) P9WGI5 (/IDA) P9WGI5 (/IDA) P9WGI5 (/IDA) P9WGI5 (/IDA) P9WGI5 (/IDA) P9WGI5 (/IDA) P9WGI5 (/IDA) P9WGI5 (/IDA)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
20 P9WGI1 (/HDA) P9WGI1 (/HDA) P9WGI1 (/HDA) P9WGI1 (/HDA) P9WGI1 (/HDA) P9WGI1 (/HDA) P9WGI1 (/HDA) P9WGI1 (/HDA) P9WGI1 (/HDA) P9WGI1 (/HDA)
(10 more)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
10 P9WGI1 (/HDA) P9WGI1 (/HDA) P9WGI1 (/HDA) P9WGI1 (/HDA) P9WGI1 (/HDA) P9WGI1 (/HDA) P9WGI1 (/HDA) P9WGI1 (/HDA) P9WGI1 (/HDA) P9WGI1 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
10 P9WGI5 (/HDA) P9WGI5 (/HDA) P9WGI5 (/HDA) P9WGI5 (/HDA) P9WGI5 (/HDA) P9WGI5 (/HDA) P9WGI5 (/HDA) P9WGI5 (/HDA) P9WGI5 (/HDA) P9WGI5 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P00579 (/IDA) P00579 (/IDA)
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