CATH Superfamily 1.10.10.10
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".
FunFam 39: Friend leukemia integration 1 transcription factor
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 13 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
19 |
P11308 (/IPI)
P11308 (/IPI)
P11308 (/IPI)
P11308 (/IPI)
P11308 (/IPI)
P11308 (/IPI)
P11308 (/IPI)
P11308 (/IPI)
P11308 (/IPI)
P11308 (/IPI)
(9 more) |
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
18 |
P11308 (/ISA)
P11308 (/ISA)
P11308 (/ISA)
P11308 (/ISA)
P11308 (/ISA)
P11308 (/ISA)
P11308 (/ISA)
P11308 (/ISA)
P11308 (/ISA)
P11308 (/ISA)
(8 more) |
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
18 |
P11308 (/ISM)
P11308 (/ISM)
P11308 (/ISM)
P11308 (/ISM)
P11308 (/ISM)
P11308 (/ISM)
P11308 (/ISM)
P11308 (/ISM)
P11308 (/ISM)
P11308 (/ISM)
(8 more) |
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
18 |
P11308 (/NAS)
P11308 (/NAS)
P11308 (/NAS)
P11308 (/NAS)
P11308 (/NAS)
P11308 (/NAS)
P11308 (/NAS)
P11308 (/NAS)
P11308 (/NAS)
P11308 (/NAS)
(8 more) |
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
18 |
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
(8 more) |
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
15 |
P11308 (/IDA)
P11308 (/IDA)
P11308 (/IDA)
P11308 (/IDA)
P11308 (/IDA)
P11308 (/IDA)
P11308 (/IDA)
P11308 (/IDA)
P11308 (/IDA)
P11308 (/IDA)
(5 more) |
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
13 |
P11308 (/IC)
P11308 (/IC)
P11308 (/IC)
P11308 (/IC)
P11308 (/IC)
P11308 (/IC)
P11308 (/IC)
P11308 (/IC)
P11308 (/IC)
P11308 (/IC)
(3 more) |
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
5 | Q01543 (/TAS) Q01543 (/TAS) Q01543 (/TAS) Q01543 (/TAS) Q01543 (/TAS) |
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
3 | P26323 (/IDA) P26323 (/IDA) P81270 (/IDA) |
RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980
Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
|
2 | P26323 (/IDA) P26323 (/IDA) |
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | P26323 (/IDA) P26323 (/IDA) |
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
2 | P26323 (/IDA) P26323 (/IDA) |
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
1 | P81270 (/ISO) |
There are 24 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
15 |
P11308 (/IDA)
P11308 (/IDA)
P11308 (/IDA)
P11308 (/IDA)
P11308 (/IDA)
P11308 (/IDA)
P11308 (/IDA)
P11308 (/IDA)
P11308 (/IDA)
P11308 (/IDA)
(5 more) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
14 |
P11308 (/IMP)
P11308 (/IMP)
P11308 (/IMP)
P11308 (/IMP)
P11308 (/IMP)
P11308 (/IMP)
P11308 (/IMP)
P11308 (/IMP)
P11308 (/IMP)
P11308 (/IMP)
(4 more) |
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
13 |
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
(3 more) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
13 |
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
(3 more) |
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
|
13 |
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
(3 more) |
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
|
10 | A0A2R8QGN6 (/IGI) A8E7Q4 (/IGI) F1QK28 (/IGI) F1R0X0 (/IGI) F1R5K9 (/IGI) Q5MBG6 (/IGI) Q5PR65 (/IGI) Q7SXF5 (/IGI) Q9PU61 (/IGI) Q9PUL6 (/IGI) |
Blood vessel morphogenesis GO:0048514
The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.
|
8 | A0A2R8QGN6 (/IGI) A8E7Q4 (/IGI) F1R0X0 (/IGI) F1R5K9 (/IGI) Q5MBG6 (/IGI) Q7SXF5 (/IGI) Q9PU61 (/IGI) Q9PUL6 (/IGI) |
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
|
5 | A8E7Q4 (/IGI) F1R0X0 (/IGI) F1R5K9 (/IGI) Q5MBG6 (/IGI) Q7SXF5 (/IGI) |
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
5 | A8E7Q4 (/IDA) F1R0X0 (/IDA) F1R5K9 (/IDA) Q5MBG6 (/IDA) Q7SXF5 (/IDA) |
Hemostasis GO:0007599
The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.
|
5 | Q01543 (/TAS) Q01543 (/TAS) Q01543 (/TAS) Q01543 (/TAS) Q01543 (/TAS) |
Animal organ morphogenesis GO:0009887
Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
|
5 | Q01543 (/TAS) Q01543 (/TAS) Q01543 (/TAS) Q01543 (/TAS) Q01543 (/TAS) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
5 | Q01543 (/IDA) Q01543 (/IDA) Q01543 (/IDA) Q01543 (/IDA) Q01543 (/IDA) |
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
3 | A0A2R8QGN6 (/IMP) Q9PU61 (/IMP) Q9PUL6 (/IMP) |
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
|
2 | F1QK28 (/IMP) Q5PR65 (/IMP) |
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P26323 (/IMP) P26323 (/IMP) |
Blood circulation GO:0008015
The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.
|
2 | P26323 (/IMP) P26323 (/IMP) |
Animal organ morphogenesis GO:0009887
Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
|
2 | P26323 (/IMP) P26323 (/IMP) |
Cellular process GO:0009987
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
|
2 | P26323 (/TAS) P26323 (/TAS) |
Megakaryocyte development GO:0035855
The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow.
|
2 | P26323 (/IMP) P26323 (/IMP) |
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
|
2 | P29776 (/IMP) P29776 (/IMP) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P26323 (/ISO) P26323 (/ISO) |
Hemangioblast cell differentiation GO:0060217
The process in which a relatively unspecialized cell acquires the characteristics of a mature hemangioblast. Hemangioblasts are the proposed common precursor of blood and endothelial lineages.
|
2 | F1QK28 (/IDA) Q5PR65 (/IDA) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | P81270 (/ISO) |
Dopaminergic neuron differentiation GO:0071542
The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine.
|
1 | Q22355 (/IMP) |
There are 10 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
17 |
A0A024R3K4 (/IDA)
A0A024R3K4 (/IDA)
A0A024R3K4 (/IDA)
A0A024R3M5 (/IDA)
A0A024R3M5 (/IDA)
A0A024R3M5 (/IDA)
A0A024R3M5 (/IDA)
A0A024R3M5 (/IDA)
A0A024R3N6 (/IDA)
A0A024R3N6 (/IDA)
(7 more) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
15 |
A0A024R3K4 (/IDA)
A0A024R3K4 (/IDA)
A0A024R3K4 (/IDA)
A0A024R3M5 (/IDA)
A0A024R3M5 (/IDA)
A0A024R3M5 (/IDA)
A0A024R3M5 (/IDA)
A0A024R3M5 (/IDA)
A0A024R3N6 (/IDA)
A0A024R3N6 (/IDA)
(5 more) |
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
15 |
A0A024R3K4 (/IDA)
A0A024R3K4 (/IDA)
A0A024R3K4 (/IDA)
A0A024R3M5 (/IDA)
A0A024R3M5 (/IDA)
A0A024R3M5 (/IDA)
A0A024R3M5 (/IDA)
A0A024R3M5 (/IDA)
A0A024R3N6 (/IDA)
A0A024R3N6 (/IDA)
(5 more) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
13 |
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
P11308 (/TAS)
(3 more) |
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
|
13 |
P11308 (/IDA)
P11308 (/IDA)
P11308 (/IDA)
P11308 (/IDA)
P11308 (/IDA)
P11308 (/IDA)
P11308 (/IDA)
P11308 (/IDA)
P11308 (/IDA)
P11308 (/IDA)
(3 more) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | P26323 (/ISO) P26323 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | P26323 (/ISO) P26323 (/ISO) |
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
2 | P26323 (/ISO) P26323 (/ISO) |
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
|
1 | P81270 (/ISO) |
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
|
1 | P81270 (/ISS) |