The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 38: Glycine cleavage system transcriptional activator

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
165 P0A9F6 (/IDA) P0A9F6 (/IDA) P0A9F6 (/IDA) P0A9F6 (/IDA) P0A9F6 (/IDA) P0A9F6 (/IDA) P0A9F6 (/IDA) P0A9F6 (/IDA) P0A9F6 (/IDA) P0A9F6 (/IDA)
(155 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
18 Q88B62 (/ISS) Q9KL71 (/ISS) Q9KL71 (/ISS) Q9KL71 (/ISS) Q9KL71 (/ISS) Q9KL71 (/ISS) Q9KL71 (/ISS) Q9KL71 (/ISS) Q9KTK6 (/ISS) Q9KTK6 (/ISS)
(8 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
9 P11720 (/IDA) P11720 (/IDA) P11720 (/IDA) P11720 (/IDA) Q9I670 (/IDA) Q9I670 (/IDA) Q9I670 (/IDA) Q9I670 (/IDA) Q9I670 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
4 P11720 (/IPI) P11720 (/IPI) P11720 (/IPI) P11720 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q57083 (/IPI)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
176 P0A9F6 (/IDA) P0A9F6 (/IDA) P0A9F6 (/IDA) P0A9F6 (/IDA) P0A9F6 (/IDA) P0A9F6 (/IDA) P0A9F6 (/IDA) P0A9F6 (/IDA) P0A9F6 (/IDA) P0A9F6 (/IDA)
(166 more)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
165 P0A9F6 (/IDA) P0A9F6 (/IDA) P0A9F6 (/IDA) P0A9F6 (/IDA) P0A9F6 (/IDA) P0A9F6 (/IDA) P0A9F6 (/IDA) P0A9F6 (/IDA) P0A9F6 (/IDA) P0A9F6 (/IDA)
(155 more)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
165 P0A9F6 (/IEP) P0A9F6 (/IEP) P0A9F6 (/IEP) P0A9F6 (/IEP) P0A9F6 (/IEP) P0A9F6 (/IEP) P0A9F6 (/IEP) P0A9F6 (/IEP) P0A9F6 (/IEP) P0A9F6 (/IEP)
(155 more)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
165 P0A9F6 (/ISS) P0A9F6 (/ISS) P0A9F6 (/ISS) P0A9F6 (/ISS) P0A9F6 (/ISS) P0A9F6 (/ISS) P0A9F6 (/ISS) P0A9F6 (/ISS) P0A9F6 (/ISS) P0A9F6 (/ISS)
(155 more)
Response to UV GO:0009411
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
165 P0A9F6 (/IMP) P0A9F6 (/IMP) P0A9F6 (/IMP) P0A9F6 (/IMP) P0A9F6 (/IMP) P0A9F6 (/IMP) P0A9F6 (/IMP) P0A9F6 (/IMP) P0A9F6 (/IMP) P0A9F6 (/IMP)
(155 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
18 Q88B62 (/ISS) Q9KL71 (/ISS) Q9KL71 (/ISS) Q9KL71 (/ISS) Q9KL71 (/ISS) Q9KL71 (/ISS) Q9KL71 (/ISS) Q9KL71 (/ISS) Q9KTK6 (/ISS) Q9KTK6 (/ISS)
(8 more)
Positive regulation of proteolysis GO:0045862
Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
7 P24734 (/IMP) P24734 (/IMP) P24734 (/IMP) P24734 (/IMP) P24734 (/IMP) P24734 (/IMP) P24734 (/IMP)
Positive regulation of protein secretion GO:0050714
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
7 P24734 (/IMP) P24734 (/IMP) P24734 (/IMP) P24734 (/IMP) P24734 (/IMP) P24734 (/IMP) P24734 (/IMP)
Negative regulation of single-species biofilm formation on inanimate substrate GO:1900232
Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation on inanimate substrate.
7 P24734 (/IMP) P24734 (/IMP) P24734 (/IMP) P24734 (/IMP) P24734 (/IMP) P24734 (/IMP) P24734 (/IMP)
Positive regulation of secondary metabolite biosynthetic process GO:1900378
Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process.
7 P24734 (/IMP) P24734 (/IMP) P24734 (/IMP) P24734 (/IMP) P24734 (/IMP) P24734 (/IMP) P24734 (/IMP)
Positive regulation of cellular amino acid biosynthetic process GO:2000284
Any process that activates or increases the frequency, rate or extent of cellular amino acid biosynthetic process.
4 P11720 (/IMP) P11720 (/IMP) P11720 (/IMP) P11720 (/IMP)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
4 P11720 (/IDA) P11720 (/IDA) P11720 (/IDA) P11720 (/IDA)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
4 P11720 (/IPI) P11720 (/IPI) P11720 (/IPI) P11720 (/IPI)
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