The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 29: Proliferation-associated 2G4, a

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
11 Q6AYD3 (/IPI) Q96327 (/IPI) Q96327 (/IPI) Q9UQ80 (/IPI) Q9UQ80 (/IPI) Q9UQ80 (/IPI) Q9UQ80 (/IPI) Q9UQ80 (/IPI) Q9UQ80 (/IPI) Q9UQ80 (/IPI)
(1 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
9 Q09184 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
8 Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
8 Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
8 Q9UQ80 (/IPI) Q9UQ80 (/IPI) Q9UQ80 (/IPI) Q9UQ80 (/IPI) Q9UQ80 (/IPI) Q9UQ80 (/IPI) Q9UQ80 (/IPI) Q9UQ80 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 P50580 (/ISO) P50580 (/ISO)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
2 P50580 (/ISO) P50580 (/ISO)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
2 P50580 (/ISO) P50580 (/ISO)
Nuclease activity GO:0004518
Catalysis of the hydrolysis of ester linkages within nucleic acids.
1 Q09184 (/TAS)
Metallopeptidase activity GO:0008237
Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
1 O60180 (/ISM)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
10 P50580 (/ISS) P50580 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS)
Positive regulation of cell differentiation GO:0045597
Any process that activates or increases the frequency, rate or extent of cell differentiation.
10 P50580 (/ISS) P50580 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
8 Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
8 Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA)
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
3 M1CZC0 (/IMP) Q96327 (/IMP) Q96327 (/IMP)
Auxin-activated signaling pathway GO:0009734
A series of molecular signals generated by the binding of the plant hormone auxin to a receptor, and ending with modulation of a downstream cellular process, e.g. transcription.
3 M1CZC0 (/IMP) Q96327 (/IMP) Q96327 (/IMP)
Regulation of cell division GO:0051302
Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells.
3 M1CZC0 (/IMP) Q96327 (/IMP) Q96327 (/IMP)
Response to cytokinin GO:0009735
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.
2 Q96327 (/IDA) Q96327 (/IDA)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 P50580 (/ISO) P50580 (/ISO)
Cell cycle G1/S phase transition GO:0044843
The cell cycle process by which a cell in G1 phase commits to S phase.
2 Q96327 (/IEP) Q96327 (/IEP)
Positive regulation of cell differentiation GO:0045597
Any process that activates or increases the frequency, rate or extent of cell differentiation.
2 P50580 (/ISO) P50580 (/ISO)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
2 P50580 (/ISO) P50580 (/ISO)
Ribosomal large subunit biogenesis GO:0042273
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.
1 O60180 (/ISO)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q6AYD3 (/IDA)
Cell cycle G1/S phase transition GO:0044843
The cell cycle process by which a cell in G1 phase commits to S phase.
1 M1CZC0 (/ISS)
Positive regulation of cell differentiation GO:0045597
Any process that activates or increases the frequency, rate or extent of cell differentiation.
1 Q6AYD3 (/IDA)

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
11 Q09184 (/IDA) Q96327 (/IDA) Q96327 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA)
(1 more)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
11 Q6AYD3 (/IDA) Q96327 (/IDA) Q96327 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA)
(1 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
11 Q387N9 (/IDA) Q387N9 (/IDA) Q6AYD3 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA)
(1 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
8 Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
8 Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA)
Azurophil granule lumen GO:0035578
The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
8 Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
8 Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P50580 (/ISO) P50580 (/ISO) Q4QDK5 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O60180 (/HDA) Q09184 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P50580 (/ISO) P50580 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 P50580 (/ISO) P50580 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 P50580 (/ISS) P50580 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P50580 (/ISS) P50580 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 O60180 (/HDA) Q09184 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q96327 (/IDA) Q96327 (/IDA)
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
2 P50580 (/ISO) P50580 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 M1CZC0 (/ISS)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
1 O60180 (/HDA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 Q1ZXG4 (/HDA)
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