The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 28: Fumarate/nitrate reduction transcriptional regulat...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
183 P0A2T8 (/IMP) P0A2T8 (/IMP) P0A2T8 (/IMP) P0A2T8 (/IMP) P0A2T8 (/IMP) P0A2T8 (/IMP) P0A2T8 (/IMP) P0A2T8 (/IMP) P0A2T8 (/IMP) P0A2T8 (/IMP)
(173 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
183 P0A2T8 (/IMP) P0A2T8 (/IMP) P0A2T8 (/IMP) P0A2T8 (/IMP) P0A2T8 (/IMP) P0A2T8 (/IMP) P0A2T8 (/IMP) P0A2T8 (/IMP) P0A2T8 (/IMP) P0A2T8 (/IMP)
(173 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
153 P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA)
(143 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
153 P0A9E5 (/IPI) P0A9E5 (/IPI) P0A9E5 (/IPI) P0A9E5 (/IPI) P0A9E5 (/IPI) P0A9E5 (/IPI) P0A9E5 (/IPI) P0A9E5 (/IPI) P0A9E5 (/IPI) P0A9E5 (/IPI)
(143 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
153 P0A9E5 (/IPI) P0A9E5 (/IPI) P0A9E5 (/IPI) P0A9E5 (/IPI) P0A9E5 (/IPI) P0A9E5 (/IPI) P0A9E5 (/IPI) P0A9E5 (/IPI) P0A9E5 (/IPI) P0A9E5 (/IPI)
(143 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
136 P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA)
(126 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
136 P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA)
(126 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
136 P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA)
(126 more)
Iron-sulfur cluster binding GO:0051536
Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms.
136 P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA)
(126 more)
4 iron, 4 sulfur cluster binding GO:0051539
Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
136 P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA)
(126 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
17 Q88F34 (/IDA) Q88F34 (/IDA) Q88F34 (/IDA) Q88F34 (/IDA) Q88F34 (/IDA) Q88F34 (/IDA) Q88F34 (/IDA) Q88F34 (/IDA) Q88F34 (/IDA) Q88F34 (/IDA)
(7 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
17 Q88F34 (/IPI) Q88F34 (/IPI) Q88F34 (/IPI) Q88F34 (/IPI) Q88F34 (/IPI) Q88F34 (/IPI) Q88F34 (/IPI) Q88F34 (/IPI) Q88F34 (/IPI) Q88F34 (/IPI)
(7 more)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
14 P23926 (/IDA) P23926 (/IDA) P23926 (/IDA) P23926 (/IDA) P23926 (/IDA) P23926 (/IDA) P23926 (/IDA) P23926 (/IDA) P23926 (/IDA) P23926 (/IDA)
(4 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
10 Q5LMN2 (/ISS) Q884U5 (/ISS) Q884U5 (/ISS) Q884U5 (/ISS) Q884U5 (/ISS) Q884U5 (/ISS) Q884U5 (/ISS) Q886B5 (/ISS) Q886B5 (/ISS) Q886B5 (/ISS)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 P46148 (/IMP)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
153 P0A9E5 (/EXP) P0A9E5 (/EXP) P0A9E5 (/EXP) P0A9E5 (/EXP) P0A9E5 (/EXP) P0A9E5 (/EXP) P0A9E5 (/EXP) P0A9E5 (/EXP) P0A9E5 (/EXP) P0A9E5 (/EXP)
(143 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
136 P0A9E5 (/IEP) P0A9E5 (/IEP) P0A9E5 (/IEP) P0A9E5 (/IEP) P0A9E5 (/IEP) P0A9E5 (/IEP) P0A9E5 (/IEP) P0A9E5 (/IEP) P0A9E5 (/IEP) P0A9E5 (/IEP)
(126 more)
Anaerobic respiration GO:0009061
The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor.
136 P0A9E5 (/IEP) P0A9E5 (/IEP) P0A9E5 (/IEP) P0A9E5 (/IEP) P0A9E5 (/IEP) P0A9E5 (/IEP) P0A9E5 (/IEP) P0A9E5 (/IEP) P0A9E5 (/IEP) P0A9E5 (/IEP)
(126 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
136 P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA)
(126 more)
Response to nitric oxide GO:0071731
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus.
136 P0A9E5 (/IEP) P0A9E5 (/IEP) P0A9E5 (/IEP) P0A9E5 (/IEP) P0A9E5 (/IEP) P0A9E5 (/IEP) P0A9E5 (/IEP) P0A9E5 (/IEP) P0A9E5 (/IEP) P0A9E5 (/IEP)
(126 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
47 P0A2T8 (/IEP) P0A2T8 (/IEP) P0A2T8 (/IEP) P0A2T8 (/IEP) P0A2T8 (/IEP) P0A2T8 (/IEP) P0A2T8 (/IEP) P0A2T8 (/IEP) P0A2T8 (/IEP) P0A2T8 (/IEP)
(37 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
17 Q88F34 (/EXP) Q88F34 (/EXP) Q88F34 (/EXP) Q88F34 (/EXP) Q88F34 (/EXP) Q88F34 (/EXP) Q88F34 (/EXP) Q88F34 (/EXP) Q88F34 (/EXP) Q88F34 (/EXP)
(7 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
15 P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP)
(5 more)
Response to decreased oxygen levels GO:0036293
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen.
14 P23926 (/IDA) P23926 (/IDA) P23926 (/IDA) P23926 (/IDA) P23926 (/IDA) P23926 (/IDA) P23926 (/IDA) P23926 (/IDA) P23926 (/IDA) P23926 (/IDA)
(4 more)
Cellular response to decreased oxygen levels GO:0036294
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen.
14 P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP)
(4 more)
Cyanide biosynthetic process GO:0046202
The chemical reactions and pathways resulting in the formation of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration.
14 P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP)
(4 more)
Positive regulation of oxidoreductase activity GO:0051353
Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered.
14 P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP)
(4 more)
Regulation of arginine catabolic process GO:1900081
Any process that modulates the frequency, rate or extent of arginine catabolic process.
14 P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP)
(4 more)
Negative regulation of phospholipase C activity GO:1900275
Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase C activity.
14 P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP) P23926 (/IMP)
(4 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
10 Q5LMN2 (/ISS) Q884U5 (/ISS) Q884U5 (/ISS) Q884U5 (/ISS) Q884U5 (/ISS) Q884U5 (/ISS) Q884U5 (/ISS) Q886B5 (/ISS) Q886B5 (/ISS) Q886B5 (/ISS)
Anaerobic respiration GO:0009061
The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor.
3 P46148 (/IMP) Q5E593 (/IMP) Q5E593 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 D8IWL7 (/IMP) D8J1B0 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
2 Q5E593 (/IMP) Q5E593 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 Q5E593 (/IMP) Q5E593 (/IMP)
Cellular response to anoxia GO:0071454
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%.
2 Q5E593 (/IMP) Q5E593 (/IMP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
183 P0A2T8 (/IMP) P0A2T8 (/IMP) P0A2T8 (/IMP) P0A2T8 (/IMP) P0A2T8 (/IMP) P0A2T8 (/IMP) P0A2T8 (/IMP) P0A2T8 (/IMP) P0A2T8 (/IMP) P0A2T8 (/IMP)
(173 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
153 P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA)
(143 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
153 P0A9E5 (/IPI) P0A9E5 (/IPI) P0A9E5 (/IPI) P0A9E5 (/IPI) P0A9E5 (/IPI) P0A9E5 (/IPI) P0A9E5 (/IPI) P0A9E5 (/IPI) P0A9E5 (/IPI) P0A9E5 (/IPI)
(143 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
136 P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA) P0A9E5 (/IDA)
(126 more)
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