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CATH Superfamily 1.10.10.10

Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 261: Transcriptional regulator SlyA

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
 96 P0A8W2 (/IMP) P0A8W2 (/IMP) P0A8W2 (/IMP) P0A8W2 (/IMP) P0A8W2 (/IMP) P0A8W2 (/IMP) P0A8W2 (/IMP) P0A8W2 (/IMP) P0A8W2 (/IMP) P0A8W2 (/IMP)
(86 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 13 B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA)
(3 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
 13 B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA)
(3 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 11 B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI)
(1 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
 11 B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI)
(1 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
 11 B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA)
(1 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
 11 B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI)
(1 more)

There are 5 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of DNA-templated transcription, initiation GO:2000143
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-templated transcription initiation.
 96 P0A8W2 (/IDA) P0A8W2 (/IDA) P0A8W2 (/IDA) P0A8W2 (/IDA) P0A8W2 (/IDA) P0A8W2 (/IDA) P0A8W2 (/IDA) P0A8W2 (/IDA) P0A8W2 (/IDA) P0A8W2 (/IDA)
(86 more)
Positive regulation of DNA-templated transcription, initiation GO:2000144
Any process that activates or increases the frequency, rate or extent of DNA-templated transcription initiation.
 96 P0A8W2 (/IDA) P0A8W2 (/IDA) P0A8W2 (/IDA) P0A8W2 (/IDA) P0A8W2 (/IDA) P0A8W2 (/IDA) P0A8W2 (/IDA) P0A8W2 (/IDA) P0A8W2 (/IDA) P0A8W2 (/IDA)
(86 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
 11 B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA)
(1 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 2 E0SG24 (/IMP) E0SG24 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
 2 E0SG24 (/EXP) E0SG24 (/EXP)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 13 B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA) B1JJ73 (/IDA)
(3 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 11 B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI) B1JJ73 (/IPI)
(1 more)