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CATH Superfamily 1.10.10.10

Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 26: HTH-type transcriptional regulator IscR

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
 156 P0AGK8 (/IDA) P0AGK8 (/IDA) P0AGK8 (/IDA) P0AGK8 (/IDA) P0AGK8 (/IDA) P0AGK8 (/IDA) P0AGK8 (/IDA) P0AGK8 (/IDA) P0AGK8 (/IDA) P0AGK8 (/IDA)
(146 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
 156 P0AGK8 (/IPI) P0AGK8 (/IPI) P0AGK8 (/IPI) P0AGK8 (/IPI) P0AGK8 (/IPI) P0AGK8 (/IPI) P0AGK8 (/IPI) P0AGK8 (/IPI) P0AGK8 (/IPI) P0AGK8 (/IPI)
(146 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 14 Q9HXI7 (/IDA) Q9HXI7 (/IDA) Q9HXI7 (/IDA) Q9HXI7 (/IDA) Q9HXI7 (/IDA) Q9HXI7 (/IDA) Q9HXI7 (/IDA) Q9HXI7 (/IDA) Q9HXI7 (/IDA) Q9HXI7 (/IDA)
(4 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
 14 Q9HXI7 (/IDA) Q9HXI7 (/IDA) Q9HXI7 (/IDA) Q9HXI7 (/IDA) Q9HXI7 (/IDA) Q9HXI7 (/IDA) Q9HXI7 (/IDA) Q9HXI7 (/IDA) Q9HXI7 (/IDA) Q9HXI7 (/IDA)
(4 more)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
 156 P0AGK8 (/IDA) P0AGK8 (/IDA) P0AGK8 (/IDA) P0AGK8 (/IDA) P0AGK8 (/IDA) P0AGK8 (/IDA) P0AGK8 (/IDA) P0AGK8 (/IDA) P0AGK8 (/IDA) P0AGK8 (/IDA)
(146 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
 156 P0AGK8 (/IMP) P0AGK8 (/IMP) P0AGK8 (/IMP) P0AGK8 (/IMP) P0AGK8 (/IMP) P0AGK8 (/IMP) P0AGK8 (/IMP) P0AGK8 (/IMP) P0AGK8 (/IMP) P0AGK8 (/IMP)
(146 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 25 Q667Y0 (/EXP) Q667Y0 (/EXP) Q667Y0 (/EXP) Q667Y0 (/EXP) Q667Y0 (/EXP) Q667Y0 (/EXP) Q667Y0 (/EXP) Q667Y0 (/EXP) Q667Y0 (/EXP) Q667Y0 (/EXP)
(15 more)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
 14 A6V0U7 (/IMP) A6V0U7 (/IMP) A6V0U7 (/IMP) A6V0U7 (/IMP) A6V0U7 (/IMP) A6V0U7 (/IMP) A6V0U7 (/IMP) A6V0U7 (/IMP) A6V0U7 (/IMP) A6V0U7 (/IMP)
(4 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 14 Q9HXI7 (/IEP) Q9HXI7 (/IEP) Q9HXI7 (/IEP) Q9HXI7 (/IEP) Q9HXI7 (/IEP) Q9HXI7 (/IEP) Q9HXI7 (/IEP) Q9HXI7 (/IEP) Q9HXI7 (/IEP) Q9HXI7 (/IEP)
(4 more)
Cellular response to iron ion GO:0071281
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.
 3 B7J5W8 (/IDA) B7J5W8 (/IDA) B7J5W8 (/IDA)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 156 P0AGK8 (/IDA) P0AGK8 (/IDA) P0AGK8 (/IDA) P0AGK8 (/IDA) P0AGK8 (/IDA) P0AGK8 (/IDA) P0AGK8 (/IDA) P0AGK8 (/IDA) P0AGK8 (/IDA) P0AGK8 (/IDA)
(146 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 14 Q9HXI7 (/IDA) Q9HXI7 (/IDA) Q9HXI7 (/IDA) Q9HXI7 (/IDA) Q9HXI7 (/IDA) Q9HXI7 (/IDA) Q9HXI7 (/IDA) Q9HXI7 (/IDA) Q9HXI7 (/IDA) Q9HXI7 (/IDA)
(4 more)