CATH Superfamily 1.10.10.10
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".
FunFam 250: transcription factor Spi-B isoform X1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
6 | F1R668 (/IPI) Q6WEE0 (/IPI) Q6WEE1 (/IPI) Q78AM8 (/IPI) Q8AW41 (/IPI) Q8JID4 (/IPI) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
6 | F1R668 (/IPI) Q6WEE0 (/IPI) Q6WEE1 (/IPI) Q78AM8 (/IPI) Q8AW41 (/IPI) Q8JID4 (/IPI) |
|
RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980
Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
|
2 | Q01892 (/IMP) Q01892 (/IMP) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | Q01892 (/ISA) Q01892 (/ISA) |
|
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | Q01892 (/IMP) Q01892 (/IMP) |
|
RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980
Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
|
1 | O35906 (/ISO) |
|
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
1 | O35906 (/ISO) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
1 | O35906 (/IDA) |
There are 15 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
6 | F1R668 (/IGI) Q6WEE0 (/IGI) Q6WEE1 (/IGI) Q78AM8 (/IGI) Q8AW41 (/IGI) Q8JID4 (/IGI) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
6 | F1R668 (/IMP) Q6WEE0 (/IMP) Q6WEE1 (/IMP) Q78AM8 (/IMP) Q8AW41 (/IMP) Q8JID4 (/IMP) |
|
Myeloid cell differentiation GO:0030099
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.
|
6 | F1R668 (/IMP) Q6WEE0 (/IMP) Q6WEE1 (/IMP) Q78AM8 (/IMP) Q8AW41 (/IMP) Q8JID4 (/IMP) |
|
Neutrophil differentiation GO:0030223
The process in which a myeloid precursor cell acquires the specialized features of a neutrophil.
|
6 | F1R668 (/IMP) Q6WEE0 (/IMP) Q6WEE1 (/IMP) Q78AM8 (/IMP) Q8AW41 (/IMP) Q8JID4 (/IMP) |
|
Macrophage differentiation GO:0030225
The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.
|
6 | F1R668 (/IMP) Q6WEE0 (/IMP) Q6WEE1 (/IMP) Q78AM8 (/IMP) Q8AW41 (/IMP) Q8JID4 (/IMP) |
|
Negative regulation of erythrocyte differentiation GO:0045647
Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation.
|
6 | F1R668 (/IMP) Q6WEE0 (/IMP) Q6WEE1 (/IMP) Q78AM8 (/IMP) Q8AW41 (/IMP) Q8JID4 (/IMP) |
|
Negative regulation of neutrophil differentiation GO:0045659
Any process that stops, prevents, or reduces the frequency, rate or extent of neutrophil differentiation.
|
6 | F1R668 (/IGI) Q6WEE0 (/IGI) Q6WEE1 (/IGI) Q78AM8 (/IGI) Q8AW41 (/IGI) Q8JID4 (/IGI) |
|
Negative regulation of neutrophil differentiation GO:0045659
Any process that stops, prevents, or reduces the frequency, rate or extent of neutrophil differentiation.
|
6 | F1R668 (/IMP) Q6WEE0 (/IMP) Q6WEE1 (/IMP) Q78AM8 (/IMP) Q8AW41 (/IMP) Q8JID4 (/IMP) |
|
Erythrocyte development GO:0048821
The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure.
|
6 | F1R668 (/IMP) Q6WEE0 (/IMP) Q6WEE1 (/IMP) Q78AM8 (/IMP) Q8AW41 (/IMP) Q8JID4 (/IMP) |
|
Regulation of myeloid leukocyte differentiation GO:0002761
Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation.
|
2 | B3GEA5 (/IMP) F1QFB6 (/IMP) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q01892 (/TAS) Q01892 (/TAS) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | Q01892 (/IMP) Q01892 (/IMP) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | O35906 (/IDA) |
|
Macrophage differentiation GO:0030225
The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.
|
1 | O35906 (/IDA) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | O35906 (/ISO) |
There are 2 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q01892 (/TAS) Q01892 (/TAS) |
|
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
1 | O35906 (/IC) |
