The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 237: DNA-directed RNA polymerase III subunit RPC6

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
7 Q9H1D9 (/IDA) Q9H1D9 (/IDA) Q9H1D9 (/IDA) Q9H1D9 (/IDA) Q9H1D9 (/IDA) Q9H1D9 (/IDA) Q9H1D9 (/IDA)
DNA-directed 5'-3' RNA polymerase activity GO:0003899
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
7 Q9H1D9 (/NAS) Q9H1D9 (/NAS) Q9H1D9 (/NAS) Q9H1D9 (/NAS) Q9H1D9 (/NAS) Q9H1D9 (/NAS) Q9H1D9 (/NAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 Q9H1D9 (/IPI) Q9H1D9 (/IPI) Q9H1D9 (/IPI) Q9H1D9 (/IPI) Q9H1D9 (/IPI) Q9H1D9 (/IPI) Q9H1D9 (/IPI)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
3 Q2T9S3 (/ISS) Q921X6 (/ISS) Q921X6 (/ISS)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
2 Q921X6 (/ISO) Q921X6 (/ISO)
DNA-directed 5'-3' RNA polymerase activity GO:0003899
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
1 O94553 (/ISO)
DNA-directed 5'-3' RNA polymerase activity GO:0003899
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
1 Q86JM3 (/ISS)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of transcription by RNA polymerase III GO:0006359
Any process that modulates the frequency, rate or extent of transcription mediated by RNA ploymerase III.
7 Q9H1D9 (/NAS) Q9H1D9 (/NAS) Q9H1D9 (/NAS) Q9H1D9 (/NAS) Q9H1D9 (/NAS) Q9H1D9 (/NAS) Q9H1D9 (/NAS)
Positive regulation of type I interferon production GO:0032481
Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
7 Q9H1D9 (/TAS) Q9H1D9 (/TAS) Q9H1D9 (/TAS) Q9H1D9 (/TAS) Q9H1D9 (/TAS) Q9H1D9 (/TAS) Q9H1D9 (/TAS)
Positive regulation of interferon-beta production GO:0032728
Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
7 Q9H1D9 (/IMP) Q9H1D9 (/IMP) Q9H1D9 (/IMP) Q9H1D9 (/IMP) Q9H1D9 (/IMP) Q9H1D9 (/IMP) Q9H1D9 (/IMP)
Positive regulation of innate immune response GO:0045089
Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
7 Q9H1D9 (/IMP) Q9H1D9 (/IMP) Q9H1D9 (/IMP) Q9H1D9 (/IMP) Q9H1D9 (/IMP) Q9H1D9 (/IMP) Q9H1D9 (/IMP)
Positive regulation of interferon-beta production GO:0032728
Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
3 Q2T9S3 (/ISS) Q921X6 (/ISS) Q921X6 (/ISS)
Positive regulation of innate immune response GO:0045089
Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
3 Q2T9S3 (/ISS) Q921X6 (/ISS) Q921X6 (/ISS)
Retina development in camera-type eye GO:0060041
The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
3 Q6DRK3 (/IMP) Q6NYQ9 (/IMP) Q7ZTZ0 (/IMP)
Positive regulation of interferon-beta production GO:0032728
Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
2 Q921X6 (/ISO) Q921X6 (/ISO)
Positive regulation of innate immune response GO:0045089
Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
2 Q921X6 (/ISO) Q921X6 (/ISO)
Transcription by RNA polymerase III GO:0006383
The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter.
1 O94553 (/ISO)
Transcription by RNA polymerase III GO:0006383
The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter.
1 Q86JM3 (/ISS)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
7 Q9H1D9 (/TAS) Q9H1D9 (/TAS) Q9H1D9 (/TAS) Q9H1D9 (/TAS) Q9H1D9 (/TAS) Q9H1D9 (/TAS) Q9H1D9 (/TAS)
RNA polymerase III complex GO:0005666
RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
7 Q9H1D9 (/IDA) Q9H1D9 (/IDA) Q9H1D9 (/IDA) Q9H1D9 (/IDA) Q9H1D9 (/IDA) Q9H1D9 (/IDA) Q9H1D9 (/IDA)
RNA polymerase III complex GO:0005666
RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
7 Q9H1D9 (/NAS) Q9H1D9 (/NAS) Q9H1D9 (/NAS) Q9H1D9 (/NAS) Q9H1D9 (/NAS) Q9H1D9 (/NAS) Q9H1D9 (/NAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 Q9H1D9 (/TAS) Q9H1D9 (/TAS) Q9H1D9 (/TAS) Q9H1D9 (/TAS) Q9H1D9 (/TAS) Q9H1D9 (/TAS) Q9H1D9 (/TAS)
RNA polymerase III complex GO:0005666
RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
3 O94553 (/ISO) Q921X6 (/ISO) Q921X6 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O94553 (/HDA)
RNA polymerase III complex GO:0005666
RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
1 Q86JM3 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O94553 (/HDA)
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