CATH Superfamily 1.10.10.10
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".
FunFam 191: Transcription factor PU.1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 24 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
5 | P17433 (/IDA) P17433 (/IDA) P17947 (/IDA) P17947 (/IDA) Q6BDS1 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
5 | P17433 (/IPI) P17433 (/IPI) P17947 (/IPI) P17947 (/IPI) Q6BDS1 (/IPI) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
4 | P17433 (/IDA) P17433 (/IDA) P17947 (/IDA) P17947 (/IDA) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
3 | P17433 (/IDA) P17433 (/IDA) Q6BDS1 (/IDA) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
2 | P17433 (/ISO) P17433 (/ISO) |
|
RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980
Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
|
2 | P17433 (/IDA) P17433 (/IDA) |
|
RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980
Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
|
2 | P17947 (/ISS) P17947 (/ISS) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | P17433 (/IDA) P17433 (/IDA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | P17947 (/ISA) P17947 (/ISA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | P17947 (/ISM) P17947 (/ISM) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | P17947 (/ISS) P17947 (/ISS) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | P17947 (/NAS) P17947 (/NAS) |
|
RNA polymerase II transcription factor binding GO:0001085
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
|
2 | P17433 (/IPI) P17433 (/IPI) |
|
RNA polymerase II transcription factor binding GO:0001085
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
|
2 | P17947 (/ISS) P17947 (/ISS) |
|
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | P17433 (/IDA) P17433 (/IDA) |
|
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | P17433 (/IDA) P17433 (/IDA) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
2 | P17433 (/IDA) P17433 (/IDA) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
2 | P17433 (/ISO) P17433 (/ISO) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
2 | P17947 (/TAS) P17947 (/TAS) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
2 | P17947 (/IPI) P17947 (/IPI) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
2 | P17433 (/ISO) P17433 (/ISO) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
2 | P17433 (/ISO) P17433 (/ISO) |
|
NFAT protein binding GO:0051525
Interacting selectively and non-covalently with NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system.
|
2 | P17433 (/IPI) P17433 (/IPI) |
|
NFAT protein binding GO:0051525
Interacting selectively and non-covalently with NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system.
|
2 | P17947 (/ISS) P17947 (/ISS) |
There are 42 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
4 | P17433 (/IDA) P17433 (/IDA) P17947 (/IDA) P17947 (/IDA) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | P17947 (/IDA) P17947 (/IDA) Q6BDS1 (/IDA) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | P17433 (/IDA) P17433 (/IDA) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | P17947 (/TAS) P17947 (/TAS) |
|
Vasculature development GO:0001944
The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.
|
2 | P17433 (/IMP) P17433 (/IMP) |
|
Lymphoid progenitor cell differentiation GO:0002320
The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages.
|
2 | P17433 (/IMP) P17433 (/IMP) |
|
Myeloid leukocyte differentiation GO:0002573
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage.
|
2 | P17433 (/IMP) P17433 (/IMP) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P17433 (/IDA) P17433 (/IDA) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | P17433 (/IDA) P17433 (/IDA) |
|
Lymphocyte differentiation GO:0030098
The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.
|
2 | P17433 (/IDA) P17433 (/IDA) |
|
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
|
2 | P17433 (/IMP) P17433 (/IMP) |
|
Macrophage differentiation GO:0030225
The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.
|
2 | P17433 (/IDA) P17433 (/IDA) |
|
Granulocyte differentiation GO:0030851
The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.
|
2 | P17433 (/IDA) P17433 (/IDA) |
|
Somatic stem cell population maintenance GO:0035019
Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line.
|
2 | P17433 (/IDA) P17433 (/IDA) |
|
Myeloid dendritic cell differentiation GO:0043011
The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin.
|
2 | P17433 (/IMP) P17433 (/IMP) |
|
Histone H3 acetylation GO:0043966
The modification of histone H3 by the addition of an acetyl group.
|
2 | P17947 (/IMP) P17947 (/IMP) |
|
Histone H3 acetylation GO:0043966
The modification of histone H3 by the addition of an acetyl group.
|
2 | P17433 (/ISO) P17433 (/ISO) |
|
Hypermethylation of CpG island GO:0044027
An increase in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes.
|
2 | P17947 (/IDA) P17947 (/IDA) |
|
Hypermethylation of CpG island GO:0044027
An increase in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes.
|
2 | P17433 (/ISO) P17433 (/ISO) |
|
Negative regulation of MHC class II biosynthetic process GO:0045347
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II.
|
2 | P17433 (/IDA) P17433 (/IDA) |
|
Regulation of erythrocyte differentiation GO:0045646
Any process that modulates the frequency, rate or extent of erythrocyte differentiation.
|
2 | P17947 (/IMP) P17947 (/IMP) |
|
Regulation of erythrocyte differentiation GO:0045646
Any process that modulates the frequency, rate or extent of erythrocyte differentiation.
|
2 | P17433 (/ISO) P17433 (/ISO) |
|
Negative regulation of gene expression, epigenetic GO:0045814
Any epigenetic process that stops, prevents or reduces the rate of gene expression.
|
2 | P17947 (/IDA) P17947 (/IDA) |
|
Negative regulation of gene expression, epigenetic GO:0045814
Any epigenetic process that stops, prevents or reduces the rate of gene expression.
|
2 | P17433 (/ISO) P17433 (/ISO) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P17433 (/ISO) P17433 (/ISO) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P17433 (/ISO) P17433 (/ISO) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | P17433 (/IDA) P17433 (/IDA) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | P17947 (/IGI) P17947 (/IGI) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | P17433 (/ISO) P17433 (/ISO) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | P17947 (/ISS) P17947 (/ISS) |
|
Anatomical structure regression GO:0060033
The developmental process in which an anatomical stucture is destroyed as a part of its normal progression.
|
2 | P17433 (/IMP) P17433 (/IMP) |
|
Pri-miRNA transcription by RNA polymerase II GO:0061614
The cellular synthesis of primary microRNA (pri-miRNA) transcripts from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. pri-miRNA transcripts are subsequently processed to produce the ~22nt miRNAs that function in gene regulation.
|
2 | P17947 (/IDA) P17947 (/IDA) |
|
Pri-miRNA transcription by RNA polymerase II GO:0061614
The cellular synthesis of primary microRNA (pri-miRNA) transcripts from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. pri-miRNA transcripts are subsequently processed to produce the ~22nt miRNAs that function in gene regulation.
|
2 | P17433 (/ISO) P17433 (/ISO) |
|
Interleukin-6-mediated signaling pathway GO:0070102
A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | P17947 (/IDA) P17947 (/IDA) |
|
Interleukin-6-mediated signaling pathway GO:0070102
A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | P17433 (/ISO) P17433 (/ISO) |
|
Negative regulation of histone H4 acetylation GO:0090241
Any process that decreases the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group.
|
2 | P17947 (/IMP) P17947 (/IMP) |
|
Negative regulation of histone H4 acetylation GO:0090241
Any process that decreases the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group.
|
2 | P17433 (/ISO) P17433 (/ISO) |
|
Apoptotic process involved in blood vessel morphogenesis GO:1902262
Any apoptotic process that is involved in blood vessel morphogenesis.
|
2 | P17433 (/IMP) P17433 (/IMP) |
|
Positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895
Any process that activates or increases the frequency, rate or extent of pri-miRNA transcription mediated by RNA polymerase II.
|
2 | P17433 (/IDA) P17433 (/IDA) |
|
Positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895
Any process that activates or increases the frequency, rate or extent of pri-miRNA transcription mediated by RNA polymerase II.
|
2 | P17947 (/ISS) P17947 (/ISS) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q6BDS1 (/IMP) |
|
Cellular response to ethanol GO:0071361
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
|
1 | Q6BDS1 (/IEP) |
There are 10 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
5 | P17433 (/IDA) P17433 (/IDA) P17947 (/IDA) P17947 (/IDA) Q6BDS1 (/IDA) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
4 | P17433 (/IDA) P17433 (/IDA) P17947 (/IDA) P17947 (/IDA) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
2 | P17433 (/ISO) P17433 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | P17433 (/ISO) P17433 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | P17947 (/IDA) P17947 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | P17433 (/ISO) P17433 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | P17433 (/TAS) P17433 (/TAS) |
|
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
2 | P17433 (/IC) P17433 (/IC) |
|
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
2 | P17947 (/IDA) P17947 (/IDA) |
|
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
2 | P17433 (/ISO) P17433 (/ISO) |
