The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 19: Crp/Fnr family transcriptional regulator

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
17 P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) Q5SIL0 (/IDA)
(7 more)
CAMP binding GO:0030552
Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate).
15 P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) Q79VI7 (/IDA)
(5 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
13 A0R5H1 (/IDA) A0R5H1 (/IDA) A0R5H1 (/IDA) A0R5H1 (/IDA) A0R5H1 (/IDA) Q5SIL0 (/IDA) Q5SIL0 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA)
(3 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
11 A0R5H1 (/IDA) A0R5H1 (/IDA) A0R5H1 (/IDA) A0R5H1 (/IDA) A0R5H1 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA)
(1 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
11 A0R5H1 (/IMP) A0R5H1 (/IMP) A0R5H1 (/IMP) A0R5H1 (/IMP) A0R5H1 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP)
(1 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
11 A0R5H1 (/IMP) A0R5H1 (/IMP) A0R5H1 (/IMP) A0R5H1 (/IMP) A0R5H1 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP)
(1 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
9 P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 P9WMH3 (/IPI) P9WMH3 (/IPI) P9WMH3 (/IPI) P9WMH3 (/IPI) P9WMH3 (/IPI) P9WMH3 (/IPI) P9WMH3 (/IPI) P9WMH3 (/IPI) P9WMH3 (/IPI)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
6 Q79VI7 (/IPI) Q79VI7 (/IPI) Q79VI7 (/IPI) Q79VI7 (/IPI) Q79VI7 (/IPI) Q79VI7 (/IPI)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
6 Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
6 Q79VI7 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
6 Q79VI7 (/IPI) Q79VI7 (/IPI) Q79VI7 (/IPI) Q79VI7 (/IPI) Q79VI7 (/IPI) Q79VI7 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q5SIL0 (/IDA) Q5SIL0 (/IDA)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
15 P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) Q79VI7 (/IDA)
(5 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
11 P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) Q5SIL0 (/IDA)
(1 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
9 P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA)
Regulation of glyoxylate cycle GO:2000874
Any process that modulates the frequency, rate or extent of glyoxylate cycle.
6 Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
5 A0R5H1 (/EXP) A0R5H1 (/EXP) A0R5H1 (/EXP) A0R5H1 (/EXP) A0R5H1 (/EXP)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
2 Q5SIL0 (/IMP) Q5SIL0 (/IMP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
11 A0R5H1 (/IDA) A0R5H1 (/IDA) A0R5H1 (/IDA) A0R5H1 (/IDA) A0R5H1 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA)
(1 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
11 A0R5H1 (/IMP) A0R5H1 (/IMP) A0R5H1 (/IMP) A0R5H1 (/IMP) A0R5H1 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP)
(1 more)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
9 P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
9 P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
6 Q79VI7 (/IPI) Q79VI7 (/IPI) Q79VI7 (/IPI) Q79VI7 (/IPI) Q79VI7 (/IPI) Q79VI7 (/IPI)