CATH Superfamily 1.10.10.10
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".
FunFam 168: Replication protein A 32 kDa subunit
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 20 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
11 |
P15927 (/IPI)
Q5Z8L1 (/IPI)
Q5Z8L1 (/IPI)
Q62193 (/IPI)
Q6H7J5 (/IPI)
Q6H7J5 (/IPI)
Q6K9U2 (/IPI)
Q6K9U2 (/IPI)
Q9VIH1 (/IPI)
Q9ZQ19 (/IPI)
(1 more) |
Damaged DNA binding GO:0003684
Interacting selectively and non-covalently with damaged DNA.
|
8 | A1L2H9 (/ISS) A1L2H9 (/ISS) Q5RC43 (/ISS) Q62193 (/ISS) Q63528 (/ISS) Q6DFS2 (/ISS) Q6IP18 (/ISS) Q6IP18 (/ISS) |
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
|
8 | A1L2H9 (/ISS) A1L2H9 (/ISS) P15927 (/ISS) Q5RC43 (/ISS) Q62193 (/ISS) Q6DFS2 (/ISS) Q6IP18 (/ISS) Q6IP18 (/ISS) |
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
|
2 | P15927 (/IDA) Q63528 (/IDA) |
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | Q62193 (/IDA) |
Damaged DNA binding GO:0003684
Interacting selectively and non-covalently with damaged DNA.
|
1 | P15927 (/IDA) |
Damaged DNA binding GO:0003684
Interacting selectively and non-covalently with damaged DNA.
|
1 | Q62193 (/ISO) |
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
|
1 | P15927 (/IC) |
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
|
1 | Q62193 (/ISO) |
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
|
1 | Q13156 (/TAS) |
Showing 1 to 10 of 20 entries
There are 60 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Telomere maintenance GO:0000723
Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.
|
8 | A1L2H9 (/ISS) A1L2H9 (/ISS) Q5RC43 (/ISS) Q62193 (/ISS) Q63528 (/ISS) Q6DFS2 (/ISS) Q6IP18 (/ISS) Q6IP18 (/ISS) |
Double-strand break repair via homologous recombination GO:0000724
The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
|
8 | A1L2H9 (/ISS) A1L2H9 (/ISS) Q5RC43 (/ISS) Q62193 (/ISS) Q63528 (/ISS) Q6DFS2 (/ISS) Q6IP18 (/ISS) Q6IP18 (/ISS) |
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
|
8 | A1L2H9 (/ISS) A1L2H9 (/ISS) Q5RC43 (/ISS) Q62193 (/ISS) Q63528 (/ISS) Q6DFS2 (/ISS) Q6IP18 (/ISS) Q6IP18 (/ISS) |
Base-excision repair GO:0006284
In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
|
8 | A1L2H9 (/ISS) A1L2H9 (/ISS) Q5RC43 (/ISS) Q62193 (/ISS) Q63528 (/ISS) Q6DFS2 (/ISS) Q6IP18 (/ISS) Q6IP18 (/ISS) |
Nucleotide-excision repair GO:0006289
A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
|
8 | A1L2H9 (/ISS) A1L2H9 (/ISS) Q5RC43 (/ISS) Q62193 (/ISS) Q63528 (/ISS) Q6DFS2 (/ISS) Q6IP18 (/ISS) Q6IP18 (/ISS) |
Mismatch repair GO:0006298
A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.
|
8 | A1L2H9 (/ISS) A1L2H9 (/ISS) Q5RC43 (/ISS) Q62193 (/ISS) Q63528 (/ISS) Q6DFS2 (/ISS) Q6IP18 (/ISS) Q6IP18 (/ISS) |
Protein localization to chromosome GO:0034502
Any process in which a protein is transported to, or maintained at, a specific location on a chromosome.
|
8 | A1L2H9 (/ISS) A1L2H9 (/ISS) Q5RC43 (/ISS) Q62193 (/ISS) Q63528 (/ISS) Q6DFS2 (/ISS) Q6IP18 (/ISS) Q6IP18 (/ISS) |
Regulation of DNA damage checkpoint GO:2000001
Any process that modulates the frequency, rate or extent of a DNA damage checkpoint.
|
6 | A1L2H9 (/ISS) A1L2H9 (/ISS) Q5RC43 (/ISS) Q62193 (/ISS) Q63528 (/ISS) Q6DFS2 (/ISS) |
DNA replication checkpoint GO:0000076
A cell cycle checkpoint that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.
|
3 | A1L2H9 (/ISS) A1L2H9 (/ISS) Q6DFS2 (/ISS) |
Regulation of double-strand break repair via homologous recombination GO:0010569
Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences.
|
3 | Q5RC43 (/ISS) Q62193 (/ISS) Q63528 (/ISS) |
Showing 1 to 10 of 60 entries
There are 23 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
8 | A1L2H9 (/ISS) A1L2H9 (/ISS) Q5RC43 (/ISS) Q62193 (/ISS) Q63528 (/ISS) Q6DFS2 (/ISS) Q6IP18 (/ISS) Q6IP18 (/ISS) |
PML body GO:0016605
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
|
8 | A1L2H9 (/ISS) A1L2H9 (/ISS) Q5RC43 (/ISS) Q62193 (/ISS) Q63528 (/ISS) Q6DFS2 (/ISS) Q6IP18 (/ISS) Q6IP18 (/ISS) |
DNA replication factor A complex GO:0005662
A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa.
|
7 | A1L2H9 (/ISS) A1L2H9 (/ISS) Q5RC43 (/ISS) Q62193 (/ISS) Q6DFS2 (/ISS) Q6IP18 (/ISS) Q6IP18 (/ISS) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
6 | P15927 (/IDA) Q13156 (/IDA) Q6K9U2 (/IDA) Q6K9U2 (/IDA) Q9ZQ19 (/IDA) Q9ZQ19 (/IDA) |
DNA replication factor A complex GO:0005662
A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa.
|
4 | P15927 (/IDA) Q13156 (/IDA) Q63528 (/IDA) Q92373 (/IDA) |
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
|
3 | P15927 (/IDA) Q6IP18 (/IDA) Q6IP18 (/IDA) |
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
|
3 | A1L2H9 (/ISS) A1L2H9 (/ISS) Q6DFS2 (/ISS) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | P15927 (/IDA) Q5TEJ0 (/IDA) Q5TEJ0 (/IDA) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | P15927 (/TAS) Q13156 (/TAS) Q62193 (/TAS) |
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
3 | P15927 (/IDA) Q5TEJ0 (/IDA) Q5TEJ0 (/IDA) |
Showing 1 to 10 of 23 entries