The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 11: Phosphate regulon transcriptional regulator PhoB

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Bacterial-type RNA polymerase holo enzyme binding GO:0001108
Interacting selectively and non-covalently with the basal transcription machinery which is composed of a bacterial-type RNA polymerase core enzyme and a sigma factor, the minimal set of factors required for formation of the preinitiation complex (PIC) by a bacterial-type RNA polymerase.
166 P0AFJ5 (/IMP) P0AFJ5 (/IMP) P0AFJ5 (/IMP) P0AFJ5 (/IMP) P0AFJ5 (/IMP) P0AFJ5 (/IMP) P0AFJ5 (/IMP) P0AFJ5 (/IMP) P0AFJ5 (/IMP) P0AFJ5 (/IMP)
(156 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
166 P0AFJ5 (/IPI) P0AFJ5 (/IPI) P0AFJ5 (/IPI) P0AFJ5 (/IPI) P0AFJ5 (/IPI) P0AFJ5 (/IPI) P0AFJ5 (/IPI) P0AFJ5 (/IPI) P0AFJ5 (/IPI) P0AFJ5 (/IPI)
(156 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
43 Q3K4G1 (/IMP) Q3K4G1 (/IMP) Q3K4G1 (/IMP) Q3K4G1 (/IMP) Q3K4G1 (/IMP) Q3K4G1 (/IMP) Q3K4G1 (/IMP) Q3K4G1 (/IMP) Q3K4G1 (/IMP) Q3K4G1 (/IMP)
(33 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
43 Q3K4G1 (/IMP) Q3K4G1 (/IMP) Q3K4G1 (/IMP) Q3K4G1 (/IMP) Q3K4G1 (/IMP) Q3K4G1 (/IMP) Q3K4G1 (/IMP) Q3K4G1 (/IMP) Q3K4G1 (/IMP) Q3K4G1 (/IMP)
(33 more)
Phosphorelay response regulator activity GO:0000156
Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
14 Q9KU11 (/ISS) Q9KU11 (/ISS) Q9KU11 (/ISS) Q9KU11 (/ISS) Q9KU11 (/ISS) Q9KU11 (/ISS) Q9KU11 (/ISS) Q9KU11 (/ISS) Q9KU11 (/ISS) Q9KU11 (/ISS)
(4 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
14 P23620 (/IDA) P23620 (/IDA) P23620 (/IDA) P23620 (/IDA) P23620 (/IDA) P23620 (/IDA) P23620 (/IDA) P23620 (/IDA) P23620 (/IDA) P23620 (/IDA)
(4 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
14 P23620 (/IDA) P23620 (/IDA) P23620 (/IDA) P23620 (/IDA) P23620 (/IDA) P23620 (/IDA) P23620 (/IDA) P23620 (/IDA) P23620 (/IDA) P23620 (/IDA)
(4 more)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of DNA-templated transcription, initiation GO:2000142
Any process that modulates the frequency, rate or extent of DNA-templated transcription initiation.
166 P0AFJ5 (/IDA) P0AFJ5 (/IDA) P0AFJ5 (/IDA) P0AFJ5 (/IDA) P0AFJ5 (/IDA) P0AFJ5 (/IDA) P0AFJ5 (/IDA) P0AFJ5 (/IDA) P0AFJ5 (/IDA) P0AFJ5 (/IDA)
(156 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
57 P23620 (/IEP) P23620 (/IEP) P23620 (/IEP) P23620 (/IEP) P23620 (/IEP) P23620 (/IEP) P23620 (/IEP) P23620 (/IEP) P23620 (/IEP) P23620 (/IEP)
(47 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
43 Q3K4G1 (/EXP) Q3K4G1 (/EXP) Q3K4G1 (/EXP) Q3K4G1 (/EXP) Q3K4G1 (/EXP) Q3K4G1 (/EXP) Q3K4G1 (/EXP) Q3K4G1 (/EXP) Q3K4G1 (/EXP) Q3K4G1 (/EXP)
(33 more)
Phosphorelay signal transduction system GO:0000160
A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
14 Q9KU11 (/ISS) Q9KU11 (/ISS) Q9KU11 (/ISS) Q9KU11 (/ISS) Q9KU11 (/ISS) Q9KU11 (/ISS) Q9KU11 (/ISS) Q9KU11 (/ISS) Q9KU11 (/ISS) Q9KU11 (/ISS)
(4 more)
Bacterial-type flagellum-dependent swarming motility GO:0071978
Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria.
14 P23620 (/IMP) P23620 (/IMP) P23620 (/IMP) P23620 (/IMP) P23620 (/IMP) P23620 (/IMP) P23620 (/IMP) P23620 (/IMP) P23620 (/IMP) P23620 (/IMP)
(4 more)
Positive regulation of cellular response to phosphate starvation GO:0080040
Any process that activates or increases the frequency, rate or extent of cellular response to phosphate starvation.
14 P23620 (/IMP) P23620 (/IMP) P23620 (/IMP) P23620 (/IMP) P23620 (/IMP) P23620 (/IMP) P23620 (/IMP) P23620 (/IMP) P23620 (/IMP) P23620 (/IMP)
(4 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 O85089 (/IMP)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
43 Q3K4G1 (/IMP) Q3K4G1 (/IMP) Q3K4G1 (/IMP) Q3K4G1 (/IMP) Q3K4G1 (/IMP) Q3K4G1 (/IMP) Q3K4G1 (/IMP) Q3K4G1 (/IMP) Q3K4G1 (/IMP) Q3K4G1 (/IMP)
(33 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
14 P23620 (/IDA) P23620 (/IDA) P23620 (/IDA) P23620 (/IDA) P23620 (/IDA) P23620 (/IDA) P23620 (/IDA) P23620 (/IDA) P23620 (/IDA) P23620 (/IDA)
(4 more)
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