CATH Classification

Domain Context

CATH Clusters

Superfamily paz domain
Functional Family Protein argonaute-2

Enzyme Information

3.1.26.n2
Argonaute-2.
based on mapping to UniProt Q9UKV8
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- The enzyme, isolated from animals, is required for RNA-mediated gene silencing (RNAi).

UniProtKB Entries (1)

Q9UKV8
AGO2_HUMAN
Homo sapiens
Protein argonaute-2

PDB Structure

PDB 6RA4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
How to Computationally Stack the Deck for Hit-to-Lead Generation: In Silico Molecular Interaction Energy Profiling for de Novo siRNA Guide Strand Surrogate Selection.
Greenidge, P.A., Blommers, M.J.J., Priestle, J.P., Hunziker, J.
J.Chem.Inf.Model.