CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.80 | Glycosidases |
Domain Context
CATH Clusters
| Superfamily | Glycosidases |
| Functional Family | Lysosomal acid glucosylceramidase |
Enzyme Information
| 2.4.1.- |
Hexosyltransferases.
based on mapping to UniProt P04062
|
| 3.2.1.104 |
Steryl-beta-glucosidase.
based on mapping to UniProt P04062
Cholesteryl-beta-D-glucoside + H(2)O = D-glucose + cholesterol.
-!- Acts on glucosides of cholesterol and sitosterol, but not on some related sterols such as coprostanol.
|
| 3.2.1.45 |
Glucosylceramidase.
based on mapping to UniProt P04062
D-glucosyl-N-acylsphingosine + H(2)O = D-glucose + N-acylsphingosine.
-!- Also acts on glucosylsphingosine (cf. EC 3.2.1.62).
|
UniProtKB Entries (1)
| P04062 |
GLCM_HUMAN
Homo sapiens
Lysosomal acid glucosylceramidase
|
PDB Structure
| PDB | 6Q6N |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish.
J.Am.Chem.Soc.
|
