CATH Domain 6o39C00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.2000	Frizzled cysteine-rich domain
	1.10.2000.10	Frizzled cysteine-rich domain

Domain Context

CATH Clusters

Superfamily	Frizzled cysteine-rich domain
Functional Family	Frizzled class receptor 8a

Enzyme Information

UniProtKB Entries (1)

FZD5_HUMAN

Homo sapiens

Frizzled-5

PDB Structure

PDB	6O39
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. Raman, S., Beilschmidt, M., To, M., Lin, K., Lui, F., Jmeian, Y., Ng, M., Fernandez, M., Fu, Y., Mascall, K., Duque, A., Wang, X., Pan, G., Angers, S., Moffat, J., Sidhu, S.S., Magram, J., Sinclair, A.M., Fransson, J., Julien, J.P. Proc. Natl. Acad. Sci. U.S.A.